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  2. CNOT3 - CCR4-NOT transcription complex subunit 3 Gene

CNOT3 - CCR4-NOT transcription complex subunit 3 Gene

中文名称:CCR4-NOT 转录复合物亚基 3

种属: Homo sapiens

同用名: NOT3; LENG2; NOT3H; IDDSADF

基因 ID: 4849 | 基因类型: protein coding

关于 CNOT3

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,137,762-54,155,681 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 270 orthologues, 1 paralogue and is associated with 74 phenotypes. Ubiquitous expression in testis (RPKM 13.9), spleen (RPKM 9.7) and 25 other tissues.

功能概要

参与调节干细胞群的维持。 CCR4-NOT 复合体的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Involved in regulation of stem cell population maintenance. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]

CNOT3 基因产物(1)

mRNA Protein Name
NM_014516.4 NP_055331.1 CCR4-NOT transcription complex subunit 3

CNOT3 蛋白结构

Not3

Not3: Not1 N-terminal domain, CCR4-Not complex component (3 - 233)

NOT2_3_5

NOT2_3_5: NOT2 / NOT3 / NOT5 family (619 - 748)

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  • 753 a.a.
蛋白主名 其他名称

CCR4-NOT transcription complex subunit 3

CCR4-associated factor 3

CNOT3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CNOT3 O75175 CNOT6L Homo sapiens Q96LI5 33961781
种属内
CNOT3 O75175 CNOT6L Homo sapiens Q96LI5 17452450
种属内
CNOT3 O75175 NEK7 Homo sapiens Q8TDX7 32814053
种属内
CNOT3 O75175 NEK7 Homo sapiens Q8TDX7 32814053
种属内
CNOT3 O75175 NEK7 Homo sapiens Q8TDX7 32814053
种属内
CNOT3 O75175 CNOT1 Homo sapiens A5YKK6 16778766
种属内
CNOT3 O75175 CNOT1 Homo sapiens A5YKK6 33961781
种属内
CNOT3 O75175 CNOT6 Homo sapiens Q9ULM6 33961781
种属内
CNOT3 O75175 DLST Homo sapiens P36957 32814053
种属内
CNOT3 O75175 DLST Homo sapiens P36957 32814053
种属内
CNOT3 O75175 DLST Homo sapiens P36957 32814053
种属内
CNOT3 O75175 VCP Homo sapiens P55072 32814053
种属内
CNOT3 O75175 VCP Homo sapiens P55072 32814053
种属内
CNOT3 O75175 VCP Homo sapiens P55072 32814053
种属间
CNOT3 O75175 Cand2 Mus musculus Q6ZQ73
Y2H
12207886
种属内
CNOT3 O75175 PECAM1 Homo sapiens P16284 32814053
种属内
CNOT3 O75175 PECAM1 Homo sapiens P16284 32814053
种属内
CNOT3 O75175 PECAM1 Homo sapiens P16284 32814053
种属内
CNOT3 O75175 TOB1 Homo sapiens P50616 18377426
种属内
CNOT3 O75175 TOB1 Homo sapiens P50616
TAP
18377426
种属内
CNOT3 O75175 CNOT8 Homo sapiens Q9UFF9 33961781
种属内
CNOT3 O75175 CNOT8 Homo sapiens Q9UFF9 10637334
种属内
CNOT3 O75175 CNOT8 Homo sapiens Q9UFF9
Y2H
10637334
种属内
CNOT3 O75175 CNOT2 Homo sapiens Q9NZN8 21984185
种属内
CNOT3 O75175 CNOT2 Homo sapiens Q9NZN8 32296183
种属内
CNOT3 O75175 CNOT2 Homo sapiens Q9NZN8 16778766
种属内
CNOT3 O75175 CNOT2 Homo sapiens Q9NZN8 33961781
种属内
CNOT3 O75175 CNOT2 Homo sapiens Q9NZN8 32296183
种属内
CNOT3 O75175 CNOT2 Homo sapiens Q9NZN8 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Intellectual Developmental Disorder With Speech Delay, Autism, And Dysmorphic Facies

IDDSADF

Intellectual Developmental Disorder With Speech Delay, Autism And Dysmorphic Facies

Precursor T-Cell Acute Lymphoblastic Leukemia

T-All

Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma

Precursor T-Cell Acute Lymphocytic Leukemia

Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Adult T-Cell Lymphoma/Leukemia

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus CNOT3 VGNC VGNC:27518
Rattus norvegicus CNOT3 RGD RGD:1304771
Mus musculus CNOT3 MGD MGI:2385261
Macaca mulatta CNOT3 VGNC VGNC:71388
Canis familiaris CNOT3 VGNC VGNC:39414