CNOT1 - CCR4-NOT transcription complex subunit 1 Gene

中文名称：CCR4-NOT 转录复合物亚基 1

种属: Homo sapiens

同用名: NOT1; CDC39; HPE12; NOT1H; VIBOS; AD-005

基因 ID: 23019 | 基因类型: protein coding

关于 CNOT1

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:58,519,951-58,629,826 (from NCBI)

This gene has 22 transcripts (splice variants), 215 orthologues and is associated with 5 phenotypes. Ubiquitous expression in testis (RPKM 56.3), esophagus (RPKM 28.6) and 25 other tissues.

功能概要

启用犰狳重复域绑定活动；分子衔接活性；和核受体结合活性。有助于聚 (A) 特异性核糖核酸酶活性。参与多个过程，包括信号转导的负调节；细胞质 mRNA 加工体组装的正调控；和基因表达的调控。位于 P 体和胞质溶胶中。 CCR4-NOT 复合体的一部分。与全脑畸形有关。 [由基因组资源联盟提供，2022 年 4 月]

Enables armadillo repeat domain binding activity; molecular adaptor activity; and nuclear receptor binding activity. Contributes to poly(A)-specific ribonuclease activity. Involved in several processes, including negative regulation of signal transduction; positive regulation of cytoplasmic mRNA processing body assembly; and regulation of gene expression. Located in P-body and cytosol. Part of CCR4-NOT complex. Implicated in holoprosencephaly. [provided by Alliance of Genome Resources, Apr 2022]

CNOT1 基因产物(3)

mRNA	Protein	Name
NM_001265612.2	NP_001252541.1	CCR4-NOT transcription complex subunit 1 isoform c
NM_016284.5	NP_057368.3	CCR4-NOT transcription complex subunit 1 isoform a
NM_206999.3	NP_996882.1	CCR4-NOT transcription complex subunit 1 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables armadillo repeat domain binding	IPI IPI: 通过物理相互作用推断	24768540	GOA
enables molecular adaptor activity	IDA IDA: 通过直接分析推断	22977175	GOA
enables nuclear estrogen receptor binding	IDA IDA: 通过直接分析推断	16778766	GOA
enables nuclear retinoic acid receptor binding	IDA IDA: 通过直接分析推断	16778766	GOA
contributes to poly(A)-specific ribonuclease activity	IDA IDA: 通过直接分析推断	21976065	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10637334	GOA
enables protein domain specific binding	IPI IPI: 通过物理相互作用推断	24768540	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in miRNA-mediated post-transcriptional gene silencing	IDA IDA: 通过直接分析推断	23172285	GOA
involved in negative regulation of intracellular estrogen receptor signaling pathway	IDA IDA: 通过直接分析推断	16778766	GOA
involved in negative regulation of retinoic acid receptor signaling pathway	IDA IDA: 通过直接分析推断	16778766	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	16778766	GOA
involved in negative regulation of translation	IDA IDA: 通过直接分析推断	24736845	GOA
involved in positive regulation of cytoplasmic mRNA processing body assembly	IDA IDA: 通过直接分析推断	21976065	GOA
involved in positive regulation of mRNA catabolic process	IMP IMP: 通过突变表型推断	22977175	GOA
involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IMP IMP: 通过突变表型推断	21278420	GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IDA IDA: 通过直接分析推断	23644599	GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IMP IMP: 通过突变表型推断	21278420	GOA
involved in regulation of stem cell population maintenance	IMP IMP: 通过突变表型推断	22367759	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of CCR4-NOT complex	IDA IDA: 通过直接分析推断	19558367	GOA
located in P-body	IDA IDA: 通过直接分析推断	21976065	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CNOT1 蛋白结构

DUF3819

Not1

0
400
800
1200
1600
2000
2376 a.a.

蛋白主名

其他名称

CCR4-NOT transcription complex subunit 1

CCR4-associated factor 1

CNOT1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CNOT1	A5YKK6	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	26496610
种属内	CNOT1	A5YKK6	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	17452450
种属内	CNOT1	A5YKK6	CNOT6	Homo sapiens	Q9ULM6	Anti Tag CoIP	26496610
种属内	CNOT1	A5YKK6	CNOT6	Homo sapiens	Q9ULM6	Anti Tag CoIP	17452450
种属内	CNOT1	A5YKK6	CNOT7	Homo sapiens	Q9UIV1	Anti Tag CoIP	26496610
种属内	CNOT1	A5YKK6	CNOT7	Homo sapiens	Q9UIV1	Anti Tag CoIP	21278420
种属内	CNOT1	A5YKK6	CNOT7	Homo sapiens	Q9UIV1	X-Ray Diffraction	22977175
种属内	CNOT1	A5YKK6	ANXA2R	Homo sapiens	Q3ZCQ2	Pull Down	30833792
种属内	CNOT1	A5YKK6	ANXA2R	Homo sapiens	Q3ZCQ2	Confocal	30833792
种属内	CNOT1	A5YKK6	TNRC6A	Homo sapiens	Q8NDV7	Anti Tag CoIP	21981923
种属内	CNOT1	A5YKK6	CNOT11	Homo sapiens	Q9UKZ1	Anti Tag CoIP	26496610
种属内	CNOT1	A5YKK6	TNRC6C	Homo sapiens	Q9HCJ0-1	Anti Tag CoIP	23463101
种属间	CNOT1	A5YKK6	Zfp36	Mus musculus	P22893	Anti Tag CoIP	21278420
种属内	CNOT1	A5YKK6	TNRC6C	Homo sapiens	Q9HCJ0	Anti Tag CoIP	21981923
种属内	CNOT1	A5YKK6	TOB1	Homo sapiens	P50616	TAP	18377426
种属内	CNOT1	A5YKK6	TOB1	Homo sapiens	P50616	Anti Tag CoIP	26496610
种属内	CNOT1	A5YKK6	TOB1	Homo sapiens	P50616	Anti Tag CoIP	18377426
种属内	CNOT1	A5YKK6	CNOT8	Homo sapiens	Q9UFF9	Pull Down	22977175
种属内	CNOT1	A5YKK6	CNOT8	Homo sapiens	Q9UFF9	Anti Tag CoIP	26496610
种属内	CNOT1	A5YKK6	CNOT2	Homo sapiens	Q9NZN8	Anti Tag CoIP	26496610
种属内	CNOT1	A5YKK6	CNOT3	Homo sapiens	O75175	Anti Tag CoIP	26496610
种属内	CNOT1	A5YKK6	TNRC6B	Homo sapiens	Q9UPQ9	Pull Down	21981923

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Holoprosencephaly 12 With Or Without Pancreatic Agenesis

HPE12	Holoprosencephaly 12, With Or Without Pancreatic Agenesis
Pancreatic Agenesis-Holoprosencephaly Syndrome

Vissers-Bodmer Syndrome

VIBOS

Alopecia-Intellectual Disability Syndrome 4

Alopecia-Mental Retardation Syndrome 4

APMR4

Pancreatic Agenesis

Partial Pancreatic Agenesis	Congenital Pancreatic Agenesis
Partial Agenesis Of The Pancreas	Agenesis, Pancreatic
Pancreatic Agenesis, Congenital

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

Spermatogenic Failure 11

SPGF11

Anemia, Congenital Dyserythropoietic, Type Ia

Congenital Dyserythropoietic Anemia Type I	Cda I
CDAN1A	Congenital Dyserythropoietic Anemia Type 1
Congenital Dyserythropoietic Anemia Type Ia	Congenital Dyserythropoietic Anemia, Type I
Anemia, Congenital Dyserythropoietic, Type I	Cda Type 1
Cda Type I	Cda Ia
Dyserythropoietic Anemia, Congenital Type 1	Anemia, Congenital Dyserythropoietic, Type 1a
Dyserythropoietic Anemia, Congenital, Type Ia	Cda, Type Ia
Congenital Dyserythropoietic Anaemia Type 1	Congenital Dyserythropoietic Anaemia Type I
Anemia, Dyserythropoietic, Congenital Type 1	Type I Congenital Dyserythropoietic Anemia
Anemia, Congenital Dyserythropoietic, 1a	Anemia, Dyserythropoietic, Congenital, Type Ia

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Gaucher Disease, Type Ii

GD2	Gd Ii
Gaucher Disease, Acute Neuronopathic Type	Gaucher Disease Type 2
Gaucher Disease Type Ii	Gaucher'S Disease Type Ii
Infantile Cerebral Gaucher Disease	Acute Neuronopathic Gaucher Disease
Gd 2	Gaucher Disease, Infantile Cerebral
Gaucher Disease 2	Type 2 Gaucher Disease
Gaucher Disease, Type 2

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02899	CNOT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	CNOT1	VGNC	VGNC:71386
Felis catus	CNOT1	VGNC	VGNC:68516
Bos taurus	CNOT1	VGNC	VGNC:27514
Rattus norvegicus	CNOT1	RGD	RGD:1308009
Mus musculus	CNOT1	MGD	MGI:2442402
Canis familiaris	CNOT1	VGNC	VGNC:39410

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