CNOT7 - CCR4-NOT transcription complex subunit 7 Gene

中文名称：CCR4-NOT 转录复合亚基 7

种属: Homo sapiens

同用名: CAF1; CAF-1; Caf1a; hCAF-1

基因 ID: 29883 | 基因类型: protein coding

关于 CNOT7

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:17,224,966-17,246,857 (from NCBI)

This gene has 13 transcripts (splice variants), 222 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 13.0), lymph node (RPKM 9.7) and 25 other tissues.

功能概要

由该基因编码的蛋白质与一种抗增殖蛋白 B 细胞易位蛋白 1 结合，后者负向调节细胞增殖。这两种蛋白质的结合由抗增殖蛋白的磷酸化驱动，导致细胞分裂中的信号事件，从而导致与细胞-细胞接触相关的细胞增殖发生变化。编码的蛋白质下调先天免疫反应，因此提供了增强其抗外来物质的抗菌活性的治疗靶点。该基因的可变剪接导致多个转录变体。已在 1 号和 X 号染色体上鉴定出相关的假基因。[RefSeq 提供，2016 年 4 月]

The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]

CNOT7 基因产物(16)

mRNA	Protein	Name
NM_001322087.2	NP_001309016.1	CCR4-NOT transcription complex subunit 7 isoform 2
NM_001322088.2	NP_001309017.1	CCR4-NOT transcription complex subunit 7 isoform 2
NM_001322089.2	NP_001309018.1	CCR4-NOT transcription complex subunit 7 isoform 2
NM_001322090.2	NP_001309019.1	CCR4-NOT transcription complex subunit 7 isoform 1
NM_001322091.2	NP_001309020.1	CCR4-NOT transcription complex subunit 7 isoform 1
NM_001322092.2	NP_001309021.1	CCR4-NOT transcription complex subunit 7 isoform 1
NM_001322093.2	NP_001309022.1	CCR4-NOT transcription complex subunit 7 isoform 3
NM_001322094.2	NP_001309023.1	CCR4-NOT transcription complex subunit 7 isoform 4
NM_001322095.2	NP_001309024.1	CCR4-NOT transcription complex subunit 7 isoform 5
NM_001322096.2	NP_001309025.1	CCR4-NOT transcription complex subunit 7 isoform 5
NM_001322097.2	NP_001309026.1	CCR4-NOT transcription complex subunit 7 isoform 5
NM_001322098.2	NP_001309027.1	CCR4-NOT transcription complex subunit 7 isoform 6
NM_001322099.2	NP_001309028.1	CCR4-NOT transcription complex subunit 7 isoform 6
NM_001322100.2	NP_001309029.1	CCR4-NOT transcription complex subunit 7 isoform 6
NM_013354.7	NP_037486.2	CCR4-NOT transcription complex subunit 7 isoform 1
NM_054026.4	NP_473367.2	CCR4-NOT transcription complex subunit 7 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 3'-5'-RNA exonuclease activity	IDA IDA: 通过直接分析推断	15769875	GOA
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	23386060	GOA
enables RNA exonuclease activity	IDA IDA: 通过直接分析推断	19276069	GOA
enables poly(A)-specific ribonuclease activity	IDA IDA: 通过直接分析推断	15769875	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9820826	GOA
enables transcription corepressor activity	IMP IMP: 通过突变表型推断	23386060	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in deadenylation-dependent decapping of nuclear-transcribed mRNA	IDA IDA: 通过直接分析推断	31439799	GOA
involved in defense response to virus	IMP IMP: 通过突变表型推断	23386060	GOA
involved in miRNA-mediated gene silencing by mRNA destabilization	IDA IDA: 通过直接分析推断	20065043	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	23386060	GOA
involved in negative regulation of cell population proliferation	IDA IDA: 通过直接分析推断	19276069	GOA
involved in negative regulation of gene expression	IMP IMP: 通过突变表型推断	25038453	GOA
involved in negative regulation of type I interferon-mediated signaling pathway	IMP IMP: 通过突变表型推断	23386060	GOA
involved in nuclear-transcribed mRNA poly(A) tail shortening	IDA IDA: 通过直接分析推断	21336257	GOA
involved in positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	19605561	GOA
involved in positive regulation of mRNA catabolic process	IMP IMP: 通过突变表型推断	23386060	GOA
involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IMP IMP: 通过突变表型推断	21278420	GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IMP IMP: 通过突变表型推断	21278420	GOA
involved in positive regulation of viral genome replication	IMP IMP: 通过突变表型推断	23386060	GOA
involved in regulation of tyrosine phosphorylation of STAT protein	IMP IMP: 通过突变表型推断	23386060	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of CCR4-NOT complex	IDA IDA: 通过直接分析推断	19558367	GOA
located in cytoplasm	IMP IMP: 通过突变表型推断	23386060	GOA
is active in intracellular non-membrane-bounded organelle	IDA IDA: 通过直接分析推断	31439799	GOA
located in nuclear speck	IMP IMP: 通过突变表型推断	23386060	GOA
located in nucleus	IDA IDA: 通过直接分析推断	9820826	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CNOT7 蛋白结构

CAF1

0
100
200
285 a.a.

蛋白主名

其他名称

CCR4-NOT transcription complex subunit 7

BTG1-binding factor 1

CNOT7 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CNOT7	Q9UIV1	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	28514442
种属内	CNOT7	Q9UIV1	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	33961781
种属内	CNOT7	Q9UIV1	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	17452450
种属内	CNOT7	Q9UIV1	CNOT1	Homo sapiens	A5YKK6	GMS	22977175
种属内	CNOT7	Q9UIV1	CNOT1	Homo sapiens	A5YKK6	Pull Down	22977175
种属内	CNOT7	Q9UIV1	CNOT1	Homo sapiens	A5YKK6	Anti Tag CoIP	22977175
种属内	CNOT7	Q9UIV1	CNOT1	Homo sapiens	A5YKK6	Anti Tag CoIP	33961781
种属内	CNOT7	Q9UIV1	CNOT6	Homo sapiens	Q9ULM6	Anti Tag CoIP	33961781
种属内	CNOT7	Q9UIV1	TOB2	Homo sapiens	Q14106	Anti Tag CoIP	28514442
种属内	CNOT7	Q9UIV1	TOB2	Homo sapiens	Q14106	Y2H Array	25416956
种属内	CNOT7	Q9UIV1	TOB2	Homo sapiens	Q14106	Anti Tag CoIP	33961781
种属内	CNOT7	Q9UIV1	TOB2	Homo sapiens	Q14106	Validated Y2H	25416956
种属内	CNOT7	Q9UIV1	PATL1	Homo sapiens	Q86TB9	Anti Tag CoIP	20584987
种属内	CNOT7	Q9UIV1	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	21981923
种属内	CNOT7	Q9UIV1	TOB1	Homo sapiens	P50616	X-Ray Diffraction	19276069
种属内	CNOT7	Q9UIV1	TOB1	Homo sapiens	P50616	Y2H Array	31515488
种属内	CNOT7	Q9UIV1	TOB1	Homo sapiens	P50616	Anti Tag CoIP	33961781
种属内	CNOT7	Q9UIV1	TOB1	Homo sapiens	P50616	ITC	20595394
种属内	CNOT7	Q9UIV1	TOB1	Homo sapiens	P50616	Anti Tag CoIP	28514442
种属内	CNOT7	Q9UIV1	TOB1	Homo sapiens	P50616	Anti Tag CoIP	21336257
种属内	CNOT7	Q9UIV1	TOB1	Homo sapiens	P50616	TAP	18377426
种属内	CNOT7	Q9UIV1	BTG1	Homo sapiens	P62324	Y2H	11136725

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02907	CNOT7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	CNOT7	VGNC	VGNC:61030
Canis familiaris	CNOT7	VGNC	VGNC:39418
Rattus norvegicus	CNOT7	RGD	RGD:1305313
Mus musculus	CNOT7	MGD	MGI:1298230
Macaca mulatta	CNOT7	VGNC	VGNC:83990
Bos taurus	CNOT7	VGNC	VGNC:27522

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CNOT7 - CCR4-NOT transcription complex subunit 7 Gene

关于 CNOT7

功能概要

CNOT7 基因产物(16)

CNOT7 蛋白结构

CNOT7 蛋白互作信息

直系同源

热门区域

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CNOT7 - CCR4-NOT transcription complex subunit 7 Gene

关于 CNOT7

功能概要

CNOT7 基因产物(16)

CNOT7 蛋白结构

CNOT7 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z