2. Gene
  3. PATL1 - PAT1 homolog 1, processing body mRNA decay factor Gene

PATL1 - PAT1 homolog 1, processing body mRNA decay factor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：PAT1 同系物 1，加工体 mRNA 衰减因子

种属: Homo sapiens

同用名: Pat1b; hPat1b

基因 ID: 219988 | 基因类型: protein coding

关于 PATL1

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:59,636,716-59,669,037 (from NCBI)

This gene has 2 transcripts (splice variants), 206 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 16.7), placenta (RPKM 9.5) and 25 other tissues.

功能概要

启用 poly (G) 结合活性和 poly (U) RNA 结合活性。参与 P 体组装和核转录 mRNA 的脱腺苷酸化依赖性脱帽。位于 P 体和胞质溶胶中。与 CCR4-NOT 复合物共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables poly(G) binding activity and poly(U) RNA binding activity. Involved in P-body assembly and deadenylation-dependent decapping of nuclear-transcribed mRNA. Located in P-body and cytosol. Colocalizes with CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]

PATL1 基因产物(1)

mRNA Protein Name
NM_152716.3 NP_689929.2 protein PAT1 homolog 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
20543818 GOA
enables poly(G) binding IDA
IDA: 通过直接分析推断
20826699 GOA
enables poly(U) RNA binding IDA
IDA: 通过直接分析推断
20826699 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20543818 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in P-body assembly IDA
IDA: 通过直接分析推断
20584987 GOA
involved in deadenylation-dependent decapping of nuclear-transcribed mRNA IDA
IDA: 通过直接分析推断
20584987 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of CCR4-NOT complex IDA
IDA: 通过直接分析推断
20584987 GOA
located in P-body IDA
IDA: 通过直接分析推断
20543818 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PATL1 蛋白结构

PAT1

PAT1: Topoisomerase II-associated protein PAT1 (15 - 439)

PAT1

PAT1: Topoisomerase II-associated protein PAT1 (460 - 717)

  • 0
  • 200
  • 400
  • 600
  • 770 a.a.
蛋白主名 其他名称

protein PAT1 homolog 1

PAT1-like protein 1

PATL1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PATL1 Q86TB9 NFKBID Homo sapiens Q8NI38
Y2H Prey Pooling
32296183
Intra PATL1 Q86TB9 NFKBID Homo sapiens Q8NI38
Validated Y2H
32296183
Intra PATL1 Q86TB9 NFKBID Homo sapiens Q8NI38
Y2H Array
32296183
Intra PATL1 Q86TB9 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra PATL1 Q86TB9 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra PATL1 Q86TB9 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra PATL1 Q86TB9 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
Intra PATL1 Q86TB9 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra PATL1 Q86TB9 WWOX Homo sapiens Q9NZC7-5
Y2H Prey Pooling
32296183
Intra PATL1 Q86TB9 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
Intra PATL1 Q86TB9 WWOX Homo sapiens Q9NZC7-5
Y2H Array
32296183
Intra PATL1 Q86TB9 CNOT1 Homo sapiens A5YKK6
Anti Tag CoIP
20584987
Intra PATL1 Q86TB9 TSC1 Homo sapiens Q86WV8
Y2H Prey Pooling
32296183
Intra PATL1 Q86TB9 TSC1 Homo sapiens Q86WV8
Validated Y2H
32296183
Intra PATL1 Q86TB9 TSC1 Homo sapiens Q86WV8
Y2H Array
32296183
Intra PATL1 Q86TB9 CNOT6 Homo sapiens Q9ULM6
Anti Tag CoIP
20584987
Intra PATL1 Q86TB9 CNOT7 Homo sapiens Q9UIV1
Anti Tag CoIP
20584987
Intra PATL1 Q86TB9 LSM2 Homo sapiens Q9Y333
Validated Y2H
32296183
Intra PATL1 Q86TB9 LSM2 Homo sapiens Q9Y333
Y2H Array
32296183
Intra PATL1 Q86TB9 LSM2 Homo sapiens Q9Y333
Y2H Prey Pooling
32296183
Intra PATL1 Q86TB9 LSM1 Homo sapiens O15116
Y2H Array
32296183
Intra PATL1 Q86TB9 LSM1 Homo sapiens O15116
Y2H Prey Pooling
32296183
Intra PATL1 Q86TB9 LSM1 Homo sapiens O15116
Anti Tag CoIP
20584987
Intra PATL1 Q86TB9 PSMA3 Homo sapiens P25788
Validated Y2H
25416956
Intra PATL1 Q86TB9 PSMA3 Homo sapiens P25788
Y2H Array
25416956
Intra PATL1 Q86TB9 DDX6 Homo sapiens P26196
Anti Tag CoIP
20584987
Intra PATL1 Q86TB9 LSM6 Homo sapiens P62312
Y2H Prey Pooling
32296183
Intra PATL1 Q86TB9 LSM6 Homo sapiens P62312
Y2H Array
32296183
Intra PATL1 Q86TB9 DCP1A Homo sapiens Q9NPI6
Anti Tag CoIP
20584987
Intra PATL1 Q86TB9 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra PATL1 Q86TB9 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra PATL1 Q86TB9 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
32296183
Intra PATL1 Q86TB9 FHL3 Homo sapiens Q13643
Y2H Array
25416956
Intra PATL1 Q86TB9 FHL3 Homo sapiens Q13643
Y2H Array
32296183
Intra PATL1 Q86TB9 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
25416956
Intra PATL1 Q86TB9 CNOT8 Homo sapiens Q9UFF9
Anti Tag CoIP
20584987
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hermansky-Pudlak Syndrome 7

HPS7

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

Delta Storage Pool Disease

Hermansky-Pudlak Syndrome, Type 7

Platelet Storage Pool Deficiency

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Retinitis Pigmentosa 13

RP13

Retinitis Pigmentosa-13

Retinitis Pigmentosa, Type 13
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10084 PATL1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PATL1 VGNC VGNC:44272
Macaca mulatta PATL1 VGNC VGNC:75684
Mus musculus PATL1 MGD MGI:2147679
Felis catus PATL1 VGNC VGNC:64049
Bos taurus PATL1 VGNC VGNC:32593
Rattus norvegicus PATL1 RGD RGD:1305514
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