DCP1A - decapping mRNA 1A Gene

中文名称：脱帽 mRNA 1A

种属: Homo sapiens

同用名: SMIF; SMAD4IP1; HSA275986; Nbla00360

基因 ID: 55802 | 基因类型: protein coding

关于 DCP1A

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:53,283,429-53,347,543 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 10.4), ovary (RPKM 7.6) and 25 other tissues.

功能概要

去盖是一般和受调节的 mRNA 衰变的关键步骤。该基因编码的蛋白质是一种脱帽酶。这种蛋白质和另一种脱帽酶形成脱帽复合物，它与无义介导的衰变因子 hUpf1 相互作用，并可能被募集到含有过早终止密码子的 mRNA 中。该蛋白还参与 TGF-β 信号通路。该基因的可变剪接导致多个转录变体。[RefSeq 提供，2014 年 2 月]

Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping Enzyme. This protein and another decapping Enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

DCP1A 基因产物(5)

mRNA	Protein	Name
NM_001290204.2	NP_001277133.1	mRNA-decapping enzyme 1A isoform b
NM_001290205.2	NP_001277134.1	mRNA-decapping enzyme 1A isoform c
NM_001290206.2	NP_001277135.1	mRNA-decapping enzyme 1A isoform d
NM_001290207.2	NP_001277136.1	mRNA-decapping enzyme 1A isoform e
NM_018403.7	NP_060873.4	mRNA-decapping enzyme 1A isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16364915	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12417715	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in mRNA methylguanosine-cap decapping	IMP IMP: 通过突变表型推断	12417715	GOA
involved in protein localization to cytoplasmic stress granule	IMP IMP: 通过突变表型推断	24965446	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	24965446	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DCP1A 蛋白结构

DCP1

0
100
200
300
400
500
582 a.a.

蛋白主名

其他名称

mRNA-decapping enzyme 1A

DCP1 decapping enzyme homolog A

DCP1A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DCP1A	Q9NPI6	EDC4	Homo sapiens	Q6P2E9	IF	16364915
种属内	DCP1A	Q9NPI6	EDC4	Homo sapiens	Q6P2E9	Anti Bait CoIP	16364915
种属内	DCP1A	Q9NPI6	EDC4	Homo sapiens	Q6P2E9	Anti Tag CoIP	16364915
种属内	DCP1A	Q9NPI6	EDC4	Homo sapiens	Q6P2E9	Anti Tag CoIP	19966221
种属内	DCP1A	Q9NPI6	EDC4	Homo sapiens	Q6P2E9	Anti Tag CoIP	26496610
种属内	DCP1A	Q9NPI6	EDC4	Homo sapiens	Q6P2E9	Anti Tag CoIP	25036637
种属内	DCP1A	Q9NPI6	PATL1	Homo sapiens	Q86TB9	Anti Tag CoIP	26496610
种属内	DCP1A	Q9NPI6	NBDY	Homo sapiens	A0A0U1RRE5	Anti Tag CoIP	27918561
种属内	DCP1A	Q9NPI6	RITA1	Homo sapiens	Q96K30	Y2H Array	25416956
种属内	DCP1A	Q9NPI6	RITA1	Homo sapiens	Q96K30	Y2H Prey Pooling	25416956
种属内	DCP1A	Q9NPI6	NSMAF	Homo sapiens	Q92636	Y2H	26133670
种属内	DCP1A	Q9NPI6	NSMAF	Homo sapiens	Q92636	Pull Down	26133670
种属内	DCP1A	Q9NPI6	BAG4	Homo sapiens	O95429	Anti Tag CoIP	26496610
种属内	DCP1A	Q9NPI6	BAG4	Homo sapiens	O95429	IF	25036637
种属内	DCP1A	Q9NPI6	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
种属内	DCP1A	Q9NPI6	SMAD4	Homo sapiens	Q13485	Y2H	15231748
种属内	DCP1A	Q9NPI6	SMAD4	Homo sapiens	Q13485	BFG-2H	27107012
种属内	DCP1A	Q9NPI6	DDX6	Homo sapiens	P26196	Anti Tag CoIP	25036637
种属内	DCP1A	Q9NPI6	DDX6	Homo sapiens	P26196	Anti Tag CoIP	19966221
种属内	DCP1A	Q9NPI6	DDX6	Homo sapiens	P26196	Anti Tag CoIP	16364915
种属内	DCP1A	Q9NPI6	DDX6	Homo sapiens	P26196	Anti Tag CoIP	26496610
种属内	DCP1A	Q9NPI6	UPF1	Homo sapiens	Q92900	Confocal	19150429
种属内	DCP1A	Q9NPI6	UPF1	Homo sapiens	Q92900	Anti Tag CoIP	12417715
种属内	DCP1A	Q9NPI6	UPF1	Homo sapiens	Q92900	Anti Tag CoIP	19150429
种属内	DCP1A	Q9NPI6	DCP2	Homo sapiens	Q8IU60	Anti Tag CoIP	19966221
种属内	DCP1A	Q9NPI6	DCP2	Homo sapiens	Q8IU60	Anti Tag CoIP	16364915
种属内	DCP1A	Q9NPI6	EDC3	Homo sapiens	Q96F86	Validated Y2H	27107012
种属内	DCP1A	Q9NPI6	EDC3	Homo sapiens	Q96F86	Anti Bait CoIP	16364915
种属内	DCP1A	Q9NPI6	EDC3	Homo sapiens	Q96F86	Anti Tag CoIP	26496610
种属内	DCP1A	Q9NPI6	DCP2	Homo sapiens	Q8IU60	Anti Tag CoIP	24510189
种属内	DCP1A	Q9NPI6	EDC3	Homo sapiens	Q96F86	Anti Tag CoIP	19966221
种属内	DCP1A	Q9NPI6	DCP2	Homo sapiens	Q8IU60	Anti Tag CoIP	23085078
种属内	DCP1A	Q9NPI6	EDC3	Homo sapiens	Q96F86	Anti Tag CoIP	16364915
种属内	DCP1A	Q9NPI6	EDC3	Homo sapiens	Q96F86	IF	16364915
种属内	DCP1A	Q9NPI6	EDC3	Homo sapiens	Q96F86	Anti Tag CoIP	35271311
种属内	DCP1A	Q9NPI6	EDC3	Homo sapiens	Q96F86	Anti Tag CoIP	25036637
种属内	DCP1A	Q9NPI6	DCP2	Homo sapiens	Q8IU60	IF	12417715
种属内	DCP1A	Q9NPI6	ZFP36	Homo sapiens	P26651	Anti Tag CoIP	16364915
种属内	DCP1A	Q9NPI6	DCP2	Homo sapiens	Q8IU60	Anti Tag CoIP	26496610
种属内	DCP1A	Q9NPI6	DCP2	Homo sapiens	Q8IU60	Anti Tag CoIP	25036637
种属内	DCP1A	Q9NPI6	DCP2	Homo sapiens	Q8IU60	Pull Down	24510189
种属内	DCP1A	Q9NPI6	DCP1B	Homo sapiens	Q8IZD4	Anti Tag CoIP	25036637
种属内	DCP1A	Q9NPI6	DCP1B	Homo sapiens	Q8IZD4	Anti Tag CoIP	19966221
种属内	DCP1A	Q9NPI6	DCP1B	Homo sapiens	Q8IZD4	Anti Tag CoIP	16364915
种属内	DCP1A	Q9NPI6	DCP1B	Homo sapiens	Q8IZD4	IF	16364915
种属内	DCP1A	Q9NPI6	DCP1B	Homo sapiens	Q8IZD4	Anti Tag CoIP	35271311
种属内	DCP1A	Q9NPI6	FHL2	Homo sapiens	Q14192	Y2H Array	31515488
种属内	DCP1A	Q9NPI6	FHL2	Homo sapiens	Q14192	Y2H Array	25416956
种属内	DCP1A	Q9NPI6	FHL2	Homo sapiens	Q14192	Y2H Prey Pooling	25416956
种属内	DCP1A	Q9NPI6	PNRC2	Homo sapiens	Q9NPJ4	Anti Tag CoIP	24510189
种属内	DCP1A	Q9NPI6	PNRC2	Homo sapiens	Q9NPJ4	Validated Y2H	32296183
种属内	DCP1A	Q9NPI6	PNRC2	Homo sapiens	Q9NPJ4	Y2H Array	25416956
种属内	DCP1A	Q9NPI6	PNRC2	Homo sapiens	Q9NPJ4	Anti Tag CoIP	19150429

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Metaphyseal Chondrodysplasia, Schmid Type

MCDS	Schmid Metaphyseal Chondrodysplasia
Metaphyseal Chondrodysplasia Schmid Type	Spondylometaphyseal Dysplasia, Japanese Type
Japanese Type Spondylometaphyseal Dysplasia	Schmid Type Metaphyseal Dysplasia
Metaphyseal Chondrodysplasia Type Schmid	Schmid Type Metaphyseal Chondrodysplasia
SMCD	Chondrodysplasia, Metaphyseal, Schmid Type
Corneal Dystrophy, Subepithelial Mucinous

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03584	DCP1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	DCP1A	VGNC	VGNC:71668
Canis familiaris	DCP1A	VGNC	VGNC:39808
Mus musculus	DCP1A	MGD	MGI:1923151
Rattus norvegicus	DCP1A	RGD	RGD:1561298
Bos taurus	DCP1A	VGNC	VGNC:27919
Felis catus	DCP1A	VGNC	VGNC:61372

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