1. Gene
  2. EDC4 - enhancer of mRNA decapping 4 Gene

EDC4 - enhancer of mRNA decapping 4 Gene

中文名称:mRNA 脱帽增强子 4

种属: Homo sapiens

同用名: GE1; Ge-1; RCD8; HEDL5; HEDLS; RCD-8

基因 ID: 23644 | 基因类型: protein coding

关于 EDC4

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,873,052-67,884,499 (from NCBI)

This gene has 14 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in testis (RPKM 17.8), bone marrow (RPKM 15.0) and 25 other tissues.

功能概要

预测参与核转录 mRNA 的去腺苷酸化独立脱帽。位于 P 体和核质中。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to be involved in deadenylation-independent decapping of nuclear-transcribed mRNA. Located in P-body and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

EDC4 基因产物(1)

mRNA Protein Name
NM_014329.5 NP_055144.3 enhancer of mRNA-decapping protein 4
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15231747 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in P-body IDA
IDA: 通过直接分析推断
20826699 GOA
located in nucleus IDA
IDA: 通过直接分析推断
7520377 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

enhancer of mRNA-decapping protein 4

autoantigen Ge-1

EDC4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
EDC4 Q6P2E9 NBDY Homo sapiens A0A0U1RRE5
Crosslink
27918561
种属内
EDC4 Q6P2E9 NBDY Homo sapiens A0A0U1RRE5
Anti Tag CoIP
27918561
种属内
EDC4 Q6P2E9 NBDY Homo sapiens A0A0U1RRE5
Pull Down
27918561
种属内
EDC4 Q6P2E9 XRN1 Homo sapiens Q8IZH2
Pull Down
24510189
种属内
EDC4 Q6P2E9 XRN1 Homo sapiens Q8IZH2
Anti Bait CoIP
20584987
种属内
EDC4 Q6P2E9 XRN1 Homo sapiens Q8IZH2
Anti Tag CoIP
24510189
种属内
EDC4 Q6P2E9 XRN1 Homo sapiens Q8IZH2
Anti Tag CoIP
35271311
种属内
EDC4 Q6P2E9 DCP1A Homo sapiens Q9NPI6
IF
16364915
种属内
EDC4 Q6P2E9 DCP1A Homo sapiens Q9NPI6
Anti Tag CoIP
24510189
种属内
EDC4 Q6P2E9 DCP1A Homo sapiens Q9NPI6
Anti Tag CoIP
35271311
种属内
EDC4 Q6P2E9 DCP1A Homo sapiens Q9NPI6
Anti Tag CoIP
16364915
种属内
EDC4 Q6P2E9 DCP2 Homo sapiens Q8IU60
Anti Tag CoIP
16364915
种属内
EDC4 Q6P2E9 DCP2 Homo sapiens Q8IU60
Anti Tag CoIP
24510189
种属内
EDC4 Q6P2E9 DCP2 Homo sapiens Q8IU60
Pull Down
24510189
种属内
EDC4 Q6P2E9 DCP2 Homo sapiens Q8IU60-2
Anti Tag CoIP
16364915
种属内
EDC4 Q6P2E9 COASY Homo sapiens Q13057
Anti Bait CoIP
22982864
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Human Granulocytic Anaplasmosis

Human Granulocytic Ehrlichiosis

Hge

Human Ehrlichial Infection, Human Granulocytic Type

Human Anaplasmosis Due To Anaplasma Phagocytophilum

Spherocytosis, Type 2

Hereditary Spherocytosis Type 2

SPH2

Spherocytosis, Hereditary, 2

Hs2

Hereditary Spherocytosis 2

Spherocytosis 2

Spherocytosis, Type 2, Autosomal Dominant

Ulnar Neuropathy

Ulnar Neuropathies

Thoracic Outlet Syndrome

Tos

Tos - Thoracic Outlet Syndrome

Thoracic Outlet Syndromes

Thoracic Outlet Compression Syndrome

Ehrlichiosis

Human Ehrlichiosis

He

Hey

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta EDC4 VGNC VGNC:72058
Bos taurus EDC4 VGNC VGNC:28321
Felis catus EDC4 VGNC VGNC:61721
Mus musculus EDC4 MGD MGI:2446249
Rattus norvegicus EDC4 RGD RGD:1562009
Canis familiaris EDC4 VGNC VGNC:40193