EDC3 - enhancer of mRNA decapping 3 Gene

中文名称：mRNA 脱帽增强子 3

种属: Homo sapiens

同用名: YJDC; LSM16; MRT50; YJEFN2; hYjeF_N2-15q23

基因 ID: 80153 | 基因类型: protein coding

关于 EDC3

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:74,630,558-74,696,024 (from NCBI)

This gene has 19 transcripts (splice variants), 247 orthologues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 14.2), ovary (RPKM 7.5) and 25 other tissues.

功能概要

该基因编码一种在 mRNA 降解中很重要的蛋白质。作为 5' 到 3' mRNA 衰变途径的一部分，编码的蛋白质是促进从 mRNA 中有效去除单甲基鸟苷 (m7G) 帽的脱帽复合物的组分。已在患有常染色体隐性智力障碍的人类患者中发现该基因的突变。[RefSeq 提供，2017 年 5 月]

This gene encodes a protein that is important in mRNA degradation. The encoded protein is a component of a decapping complex that promotes efficient removal of the monomethylguanosine (m7G) cap from mRNAs, as part of the 5' to 3' mRNA decay pathway. Mutations in this gene have been identified in human patients with an autosomal recessive form of intellectual disability. [provided by RefSeq, May 2017]

EDC3 基因产物(5)

mRNA	Protein	Name
NM_001142443.3	NP_001135915.1	enhancer of mRNA-decapping protein 3 isoform 1
NM_001142444.3	NP_001135916.1	enhancer of mRNA-decapping protein 3 isoform 1
NM_001351378.2	NP_001338307.1	enhancer of mRNA-decapping protein 3 isoform 1
NM_001351379.2	NP_001338308.1	enhancer of mRNA-decapping protein 3 isoform 2
NM_025083.5	NP_079359.2	enhancer of mRNA-decapping protein 3 isoform 1

EDC3 蛋白结构

LSM14

FDF

YjeF_N

0
100
200
300
400
508 a.a.

蛋白主名

其他名称

enhancer of mRNA-decapping protein 3

LSM16 homolog (EDC3, S. cerevisiae)

EDC3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	EDC3	Q96F86	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
种属内	EDC3	Q96F86	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
种属内	EDC3	Q96F86	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	25416956
种属内	EDC3	Q96F86	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
种属内	EDC3	Q96F86	PIAS2	Homo sapiens	O75928-2	Y2H Array	32296183
种属内	EDC3	Q96F86	PIAS2	Homo sapiens	O75928-2	Y2H Prey Pooling	32296183
种属内	EDC3	Q96F86	DDX6	Homo sapiens	P26196	Y2H Array	32296183
种属内	EDC3	Q96F86	DDX6	Homo sapiens	P26196	Anti Tag CoIP	16364915
种属内	EDC3	Q96F86	DDX6	Homo sapiens	P26196	Y2H Array	25416956
种属内	EDC3	Q96F86	DDX6	Homo sapiens	P26196	Anti Tag CoIP	33961781
种属内	EDC3	Q96F86	DDX6	Homo sapiens	P26196	Y2H Prey Pooling	32296183
种属内	EDC3	Q96F86	DDX6	Homo sapiens	P26196	Anti Tag CoIP	35271311
种属内	EDC3	Q96F86	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	28514442
种属内	EDC3	Q96F86	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	33961781
种属内	EDC3	Q96F86	DCP1A	Homo sapiens	Q9NPI6	Y2H Prey Pooling	32296183
种属内	EDC3	Q96F86	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	35271311
种属内	EDC3	Q96F86	DCP1A	Homo sapiens	Q9NPI6	Validated Y2H	32296183
种属内	EDC3	Q96F86	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	16364915
种属内	EDC3	Q96F86	DCP1A	Homo sapiens	Q9NPI6	BFG-2H	27107012
种属内	EDC3	Q96F86	DCP1A	Homo sapiens	Q9NPI6	Y2H Array	32296183
种属内	EDC3	Q96F86	DCP1B	Homo sapiens	Q8IZD4	Validated Y2H	25416956
种属内	EDC3	Q96F86	DCP1B	Homo sapiens	Q8IZD4	Anti Tag CoIP	33961781
种属内	EDC3	Q96F86	DCP1B	Homo sapiens	Q8IZD4	Y2H Array	25416956
种属内	EDC3	Q96F86	DCP1B	Homo sapiens	Q8IZD4	Y2H	21516116
种属内	EDC3	Q96F86	DCP1B	Homo sapiens	Q8IZD4	Anti Tag CoIP	28514442
种属内	EDC3	Q96F86	DCP1B	Homo sapiens	Q8IZD4	Y2H Prey Pooling	25416956
种属内	EDC3	Q96F86	DCP1B	Homo sapiens	Q8IZD4	Anti Tag CoIP	35271311
种属内	EDC3	Q96F86	ANXA10	Homo sapiens	Q9UJ72	Y2H Prey Pooling	32296183
种属内	EDC3	Q96F86	ANXA10	Homo sapiens	Q9UJ72	Y2H Array	31515488
种属内	EDC3	Q96F86	ANXA10	Homo sapiens	Q9UJ72	Validated Y2H	32296183
种属内	EDC3	Q96F86	ANXA10	Homo sapiens	Q9UJ72	Y2H Array	32296183
种属内	EDC3	Q96F86	ANXA10	Homo sapiens	Q9UJ72	Y2H Prey Pooling	25416956
种属内	EDC3	Q96F86	ANXA10	Homo sapiens	Q9UJ72	Y2H	21516116

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Intellectual Developmental Disorder, Autosomal Recessive 50

MRT50	Mental Retardation, Autosomal Recessive 50
Autosomal Recessive Intellectual Developmental Disorder 50	Mental Retardation, Autosomal Recessive, Type 50

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Epiphyseal Dysplasia, Multiple, 3

EDM3	Multiple Epiphyseal Dysplasia 3
Epiphyseal Dysplasia, Multiple, 3, With Or Without Myopathy	Multiple Epiphyseal Dysplasia 3 With Or Without Myopathy
Epiphyseal Dysplasia Multiple 3	Dysplasia, Epiphyseal, Multiple, Type 3

Epiphyseal Dysplasia, Multiple, 4

EDM4	Multiple Epiphyseal Dysplasia 4
Multiple Epiphyseal Dysplasia With Clubfoot	Multiple Epiphyseal Dysplasia Type 4
Multiple Epiphyseal Dysplasia, Autosomal Recessive	Multiple Epiphyseal Dysplasia With Bilayered Patellae
Med4	Polyepiphyseal Dysplasia Type 4
Rmed	Autosomal Recessive Multiple Epiphyseal Dysplasia
Multiple Epiphyseal Dysplasia With Bilateral Patellae	Epiphyseal Dysplasia Multiple 4
Multiple Epiphyseal Dysplasia With Double-Layered Patella	Dysplasia, Epiphyseal, Multiple, Type 4

Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04155	EDC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	EDC3	VGNC	VGNC:61720
Bos taurus	EDC3	VGNC	VGNC:28320
Rattus norvegicus	EDC3	RGD	RGD:1306898
Mus musculus	EDC3	MGD	MGI:2142951
Macaca mulatta	EDC3	VGNC	VGNC:72114
Canis familiaris	EDC3	VGNC	VGNC:40192

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