ZFP36 - ZFP36 ring finger protein Gene

中文名称：ZFP36 无名指蛋白

种属: Homo sapiens

同用名: TTP; G0S24; GOS24; TIS11; NUP475; zfp-36; RNF162A

基因 ID: 7538 | 基因类型: protein coding

关于 ZFP36

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,406,847-39,409,407 (from NCBI)

This gene has 5 transcripts (splice variants), 193 orthologues and 2 paralogues. Ubiquitous expression in gall bladder (RPKM 274.6), bone marrow (RPKM 248.5) and 25 other tissues.

功能概要

启用多种功能，包括 14-3-3 蛋白结合活性；热休克蛋白结合活性；和 mRNA 3'-UTR AU 富集区结合活性。参与多个过程，包括细胞对细胞因子刺激的反应；细胞对生长因子刺激的反应；和基因表达的调控。在 mRNA 分解代谢过程的上游或内部起作用。位于细胞质核糖核蛋白颗粒；胞质溶胶；和核。核糖核蛋白复合物的一部分。与 RISC 加载复合体共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including 14-3-3 protein binding activity; heat shock protein binding activity; and mRNA 3'-UTR AU-rich region binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to growth factor stimulus; and regulation of gene expression. Acts upstream of or within mRNA catabolic process. Located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleus. Part of ribonucleoprotein complex. Colocalizes with RISC-loading complex. [provided by Alliance of Genome Resources, Apr 2022]

ZFP36 基因产物(1)

mRNA	Protein	Name
NM_003407.5	NP_003398.3	mRNA decay activator protein ZFP36

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 14-3-3 protein binding	IDA IDA: 通过直接分析推断	15014438	GOA
enables C-C chemokine binding	IPI IPI: 通过物理相互作用推断	21784977	GOA
enables enzyme binding	IPI IPI: 通过物理相互作用推断	25038453	GOA
enables heat shock protein binding	IDA IDA: 通过直接分析推断	20221403	GOA
enables mRNA 3'-UTR AU-rich region binding	IDA IDA: 通过直接分析推断	9703499	GOA
enables mRNA 3'-UTR AU-rich region binding	IMP IMP: 通过突变表型推断	21784977	GOA
enables mRNA binding	IDA IDA: 通过直接分析推断	11782475	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	14679154	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	15014438	GOA
enables protein-containing complex binding	IPI IPI: 通过物理相互作用推断	16364915	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in 3'-UTR-mediated mRNA destabilization	IDA IDA: 通过直接分析推断	9703499	GOA
involved in 3'-UTR-mediated mRNA destabilization	IMP IMP: 通过突变表型推断	14679154	GOA
involved in 3'-UTR-mediated mRNA stabilization	IDA IDA: 通过直接分析推断	15014438	GOA
involved in MAPK cascade	IMP IMP: 通过突变表型推断	15187101	GOA
involved in cellular response to epidermal growth factor stimulus	IDA IDA: 通过直接分析推断	20166898	GOA
involved in cellular response to fibroblast growth factor stimulus	IDA IDA: 通过直接分析推断	20166898	GOA
involved in cellular response to glucocorticoid stimulus	IDA IDA: 通过直接分析推断	20166898	GOA
involved in cellular response to granulocyte macrophage colony-stimulating factor stimulus	IDA IDA: 通过直接分析推断	20166898	GOA
involved in cellular response to lipopolysaccharide	IDA IDA: 通过直接分析推断	14766228	GOA
involved in cellular response to lipopolysaccharide	IMP IMP: 通过突变表型推断	14679154	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: 通过直接分析推断	20166898	GOA
acts upstream of or within mRNA catabolic process	IDA IDA: 通过直接分析推断	10751406	GOA
involved in mRNA catabolic process	IDA IDA: 通过直接分析推断	10330172	GOA
involved in mRNA transport	IMP IMP: 通过突变表型推断	17369404	GOA
involved in negative regulation of erythrocyte differentiation	IDA IDA: 通过直接分析推断	20702587	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	21784977	GOA
involved in negative regulation of viral transcription	IMP IMP: 通过突变表型推断	14679154	GOA
involved in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA IDA: 通过直接分析推断	23644599	GOA
involved in nuclear-transcribed mRNA catabolic process, deadenylation-independent decay	IDA IDA: 通过直接分析推断	11279239	GOA
involved in nuclear-transcribed mRNA poly(A) tail shortening	IMP IMP: 通过突变表型推断	23644599	GOA
involved in positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA	IDA IDA: 通过直接分析推断	16364915	GOA
involved in positive regulation of intracellular mRNA localization	IMP IMP: 通过突变表型推断	17369404	GOA
involved in positive regulation of miRNA-mediated gene silencing	IMP IMP: 通过突变表型推断	15766526	GOA
involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA IDA: 通过直接分析推断	12748283	GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IDA IDA: 通过直接分析推断	10330172	GOA
involved in regulation of keratinocyte apoptotic process	IMP IMP: 通过突变表型推断	27182009	GOA
involved in regulation of keratinocyte differentiation	IMP IMP: 通过突变表型推断	27182009	GOA
involved in regulation of keratinocyte proliferation	IMP IMP: 通过突变表型推断	27182009	GOA
involved in regulation of mRNA stability	IDA IDA: 通过直接分析推断	9703499	GOA
involved in regulation of mRNA stability	IMP IMP: 通过突变表型推断	15187101	GOA
involved in regulation of tumor necrosis factor production	IDA IDA: 通过直接分析推断	15014438	GOA
involved in response to starvation	IDA IDA: 通过直接分析推断	15014438	GOA
involved in response to wounding	IDA IDA: 通过直接分析推断	27182009	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in P-body	IDA IDA: 通过直接分析推断	17369404	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	10330172	GOA
located in cytoplasmic stress granule	IDA IDA: 通过直接分析推断	15014438	GOA
located in cytosol	IDA IDA: 通过直接分析推断	10751406	GOA
NOT part of exosome (RNase complex)	IDA IDA: 通过直接分析推断	11719186	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10330172	GOA
part of ribonucleoprotein complex	IDA IDA: 通过直接分析推断	10330172	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZFP36 蛋白结构

zf-CCCH

0
100
200
300
326 a.a.

蛋白主名

其他名称

mRNA decay activator protein ZFP36

G0/G1 switch regulatory protein 24

ZFP36 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ZFP36	P26651	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
种属内	ZFP36	P26651	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
种属内	ZFP36	P26651	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
种属内	ZFP36	P26651	RUNX1T1	Homo sapiens	Q06455-2	Validated Y2H	32296183
种属内	ZFP36	P26651	VIM	Homo sapiens	P08670	Y2H Pooling	32814053
种属内	ZFP36	P26651	VIM	Homo sapiens	P08670	Validated Y2H	32814053
种属内	ZFP36	P26651	VIM	Homo sapiens	P08670	Y2H Array	32814053
种属内	ZFP36	P26651	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	16364915
种属内	ZFP36	P26651	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
种属内	ZFP36	P26651	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
种属内	ZFP36	P26651	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
种属内	ZFP36	P26651	EDC3	Homo sapiens	Q96F86	Anti Tag CoIP	16364915

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cervical Non-Keratinizing Squamous Cell Carcinoma

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS16042	ZFP36L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS16040	ZFP36 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS16041	ZFP36L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	ZFP36	VGNC	VGNC:48612
Rattus norvegicus	ZFP36	RGD	RGD:620722
Bos taurus	ZFP36	VGNC	VGNC:37162
Mus musculus	ZFP36	MGD	MGI:99180

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