BAG4 - BAG cochaperone 4 Gene

中文名称：BAG 辅伴侣 4

种属: Homo sapiens

同用名: SODD; BAG-4

关于 BAG4

功能概要

该基因编码的蛋白质是 BAG1 相关蛋白质家族的成员。 BAG1 是一种抗凋亡蛋白，通过与多种细胞凋亡和生长相关蛋白相互作用发挥作用，包括 BCL-2、Raf 蛋白激酶、类固醇激素受体、生长因子受体和热休克蛋白 70 kDa 家族成员。该蛋白在 C 端附近包含一个 BAG 结构域，可以结合并抑制 Hsc70/HSP70 的分子伴侣活性。该蛋白被发现与肿瘤坏死因子受体 1 (TNF-R1) 和死亡受体 3 (DR3) 的死亡结构域相关，从而负向调节下游细胞死亡信号。这种蛋白质在细胞死亡中的调节作用在上皮细胞中得到证实，上皮细胞在整合素介导的基质接触丢失时经历凋亡。已经鉴定出编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 3 月]

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell Apoptosis and growth related proteins including Bcl-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/HSP70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo Apoptosis while Integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]