KIF5B - kinesin family member 5B Gene

中文名称：驱动蛋白家族成员 5B

种属: Homo sapiens

同用名: KNS; KINH; KNS1; UKHC; HEL-S-61

基因 ID: 3799 | 基因类型: protein coding

关于 KIF5B

Cytogenetic location: 10p11.22 Genomic coordinates (GRCh38): 10:32,009,015-32,056,425 (from NCBI)

This gene has 2 transcripts (splice variants), 290 orthologues, 41 paralogues and is associated with 71 phenotypes. Ubiquitous expression in testis (RPKM 44.1), gall bladder (RPKM 42.8) and 25 other tissues.

功能概要

实现相同的蛋白质结合活性；微管结合活性；和微管运动活动。参与多个过程，包括溶酶体定位；自然杀伤细胞介导的细胞毒性；和蛋白质定位到质膜的正调节。位于中心卫星；胞质溶胶；和囊泡。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity; microtubule binding activity; and microtubule motor activity. Involved in several processes, including lysosome localization; natural killer cell mediated cytotoxicity; and positive regulation of protein localization to plasma membrane. Located in centriolar satellite; cytosol; and vesicle. [provided by Alliance of Genome Resources, Apr 2022]

KIF5B 基因产物(1)

mRNA	Protein	Name
NM_004521.3	NP_004512.1	kinesin-1 heavy chain

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	17013387	GOA
enables microtubule binding	IDA IDA: 通过直接分析推断	28426968	GOA
enables microtubule motor activity	IDA IDA: 通过直接分析推断	28426968	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15161933	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in centrosome localization	IMP IMP: 通过突变表型推断	20386726	GOA
involved in lysosome localization	IMP IMP: 通过突变表型推断	22172677	GOA
involved in natural killer cell mediated cytotoxicity	IMP IMP: 通过突变表型推断	24088571	GOA
involved in positive regulation of potassium ion transport	IDA IDA: 通过直接分析推断	19675065	GOA
involved in positive regulation of protein localization to plasma membrane	IDA IDA: 通过直接分析推断	19675065	GOA
involved in regulation of membrane potential	IDA IDA: 通过直接分析推断	19675065	GOA
involved in vesicle transport along microtubule	IDA IDA: 通过直接分析推断	28426968	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in vesicle	IDA IDA: 通过直接分析推断	20682791	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KIF5B 蛋白结构

Kinesin

0
200
400
600
800
963 a.a.

蛋白主名

其他名称

kinesin-1 heavy chain

conventional kinesin heavy chain

KIF5B 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	KIF5B	P33176	CDR2	Homo sapiens	Q01850	Y2H Array	32296183
种属内	KIF5B	P33176	CDR2	Homo sapiens	Q01850	Validated Y2H	32296183
种属内	KIF5B	P33176	CDR2	Homo sapiens	Q01850	Y2H Prey Pooling	32296183
种属内	KIF5B	P33176	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
种属内	KIF5B	P33176	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
种属内	KIF5B	P33176	POU6F2	Homo sapiens	P78424	Validated Y2H	32296183
种属内	KIF5B	P33176	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
种属内	KIF5B	P33176	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
种属内	KIF5B	P33176	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
种属内	KIF5B	P33176	LBX1	Homo sapiens	P52954	Y2H Prey Pooling	32296183
种属内	KIF5B	P33176	LBX1	Homo sapiens	P52954	Validated Y2H	32296183
种属内	KIF5B	P33176	LBX1	Homo sapiens	P52954	Y2H Array	32296183
种属内	KIF5B	P33176	PRKAR1B	Homo sapiens	P31321	Y2H Prey Pooling	32296183
种属内	KIF5B	P33176	PRKAR1B	Homo sapiens	P31321	Y2H Array	32296183
种属内	KIF5B	P33176	PRKAR2B	Homo sapiens	P31323	Y2H Array	32296183
种属内	KIF5B	P33176	PRKAR2B	Homo sapiens	P31323	Y2H Prey Pooling	32296183
种属内	KIF5B	P33176	BAG4	Homo sapiens	O95429	Y2H Array	32296183
种属内	KIF5B	P33176	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
种属内	KIF5B	P33176	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
种属内	KIF5B	P33176	YWHAZ	Homo sapiens	P63104	CoIP	15324660
种属内	KIF5B	P33176	POLR2G	Homo sapiens	P62487	Validated Y2H	32296183
种属内	KIF5B	P33176	POLR2G	Homo sapiens	P62487	Y2H Array	32296183
种属内	KIF5B	P33176	YWHAG	Homo sapiens	P61981	CoIP	15324660
种属内	KIF5B	P33176	YWHAB	Homo sapiens	P31946	CoIP	15324660
种属内	KIF5B	P33176	YWHAQ	Homo sapiens	P27348	CoIP	15324660
种属内	KIF5B	P33176	FHL2	Homo sapiens	Q14192	Validated Y2H	32296183
种属内	KIF5B	P33176	FHL2	Homo sapiens	Q14192	Y2H Array	32296183
种属内	KIF5B	P33176	FHL2	Homo sapiens	Q14192	Y2H Prey Pooling	32296183
种属内	KIF5B	P33176	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
种属内	KIF5B	P33176	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
种属间	KIF5B	P33176	OPG164	vaccinia virus	P68619	Pull Down	21915095
种属内	KIF5B	P33176	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	32296183
种属内	KIF5B	P33176	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	32296183
种属内	KIF5B	P33176	ZBTB8A	Homo sapiens	Q96BR9	Validated Y2H	32296183
种属内	KIF5B	P33176	GCC1	Homo sapiens	Q96CN9	Validated Y2H	32296183
种属内	KIF5B	P33176	GCC1	Homo sapiens	Q96CN9	Y2H Prey Pooling	32296183
种属内	KIF5B	P33176	GCC1	Homo sapiens	Q96CN9	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

KIF5B 抗体

目录号	产品名	应用	反应物种
HY-P83396	KIF5B Antibody (YA3141)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Histiocytosis

Chronic Histiocytosis X	Hand Schuller Christian Disease
Hand-Schüller-Christian Disease	Histiocytic Syndrome
Histiocytosis, Langerhans-Cell

Lung Combined Large Cell Neuroendocrine Carcinoma

Combined Large Cell Neuroendocrine Carcinoma Of Lung	Pulmonary Combined Large Cell Neuroendocrine Carcinoma
Combined Large Cell Lung Neuroendocrine Carcinoma

Occipital Lobe Neoplasm

Neoplasm Of Occipital Lobe	Malignant Neoplasm Of Occipital Lobe
Tumor Of Occipital Lobe

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Spastic Paraplegia 10, Autosomal Dominant

SPG10	Hereditary Spastic Paraplegia 10
Autosomal Dominant Spastic Paraplegia Type 10	Spastic Paraplegia 10
Spastic Paraplegia 10 With Or Without Peripheral Neuropathy	Autosomal Dominant Spastic Paraplegia 10
Autosomal Dominant Spastic Paraplegia	Spastic Paraplegia, Autosomal Dominant
Paraplegia, Spastic, Autosomal Dominant, Type 10

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-133551	WF-47-JS03	Inhibitor	99.63%	否
HY-146710	RET-IN-16	Inhibitor	/	否
HY-RS07290	KIF5B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	KIF5B	RGD	RGD:621559
Bos taurus	KIF5B	VGNC	VGNC:30606
Felis catus	KIF5B	VGNC	VGNC:67945
Mus musculus	KIF5B	MGD	MGI:1098268
Canis familiaris	KIF5B	VGNC	VGNC:42408
Macaca mulatta	KIF5B	VGNC	VGNC:74020

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