PRKAR2B - protein kinase cAMP-dependent type II regulatory subunit beta Gene

中文名称：蛋白激酶 cAMP 依赖型 II 型调节亚基 β

种属: Homo sapiens

同用名: PRKAR2; RII-BETA

基因 ID: 5577 | 基因类型: protein coding

关于 PRKAR2B

Cytogenetic location: 7q22.3 Genomic coordinates (GRCh38): 7:107,044,705-107,161,811 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 218 orthologues and 4 paralogues. Biased expression in fat (RPKM 215.5), adrenal (RPKM 38.6) and 7 other tissues.

功能概要

cAMP 是一种对多种细胞功能很重要的信号分子。 cAMP 通过激活依赖于 cAMP 的蛋白激酶发挥作用，后者通过不同靶蛋白的磷酸化来转导信号。无活性激酶全酶是由两个调节亚基和两个催化亚基组成的四聚体。 cAMP 导致非活性全酶解离成与四个 cAMP 和两个游离单体催化亚基结合的调节亚基二聚体。已在人类中鉴定出四种不同的调节亚基和三种催化亚基。该基因编码的蛋白质是调节亚基之一。该亚基可被活化的催化亚基磷酸化。该亚基已被证明与活化 T 细胞中的 cAMP 反应元件结合蛋白 1 (CREB1) 相互作用并抑制其转录活性。小鼠基因敲除研究表明，该亚基可能在调节能量平衡和肥胖方面发挥重要作用。研究还表明，该亚基可能介导氟哌啶醇诱导的基因诱导和强直行为。[RefSeq 提供，2008 年 7 月]

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008]

PRKAR2B 基因产物(1)

mRNA	Protein	Name
NM_002736.3	NP_002727.2	cAMP-dependent protein kinase type II-beta regulatory subunit

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cAMP-dependent protein kinase inhibitor activity	IDA IDA: 通过直接分析推断	21812984	GOA
enables cAMP-dependent protein kinase regulator activity	IDA IDA: 通过直接分析推断	21812984	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17148597	GOA
enables protein kinase A catalytic subunit binding	IPI IPI: 通过物理相互作用推断	21812984	GOA
enables ubiquitin protein ligase binding	IDA IDA: 通过直接分析推断	21423175	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of cAMP/PKA signal transduction	IDA IDA: 通过直接分析推断	21812984	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in centrosome	IDA IDA: 通过直接分析推断	21399614	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	21423175	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	21423175	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRKAR2B 蛋白结构

RIIa

cNMP_binding

0
100
200
300
418 a.a.

蛋白主名

其他名称

cAMP-dependent protein kinase type II-beta regulatory subunit

H_RG363E19.2

PRKAR2B 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PRKAR2B	P31323	AKAP7	Homo sapiens	O43687-2	Y2H Prey Pooling	32296183
种属内	PRKAR2B	P31323	AKAP7	Homo sapiens	O43687-2	Y2H Array	32296183
种属内	PRKAR2B	P31323	AKAP7	Homo sapiens	O43687-2	MAPPIT	32296183
种属内	PRKAR2B	P31323	TAF12	Homo sapiens	Q16514	Y2H Prey Pooling	32296183
种属内	PRKAR2B	P31323	TAF12	Homo sapiens	Q16514	Validated Y2H	32296183
种属内	PRKAR2B	P31323	TAF12	Homo sapiens	Q16514	Y2H Array	32296183
种属内	PRKAR2B	P31323	AKAP14	Homo sapiens	Q86UN6	Y2H Prey Pooling	32296183
种属内	PRKAR2B	P31323	AKAP14	Homo sapiens	Q86UN6	Validated Y2H	32296183
种属内	PRKAR2B	P31323	AKAP14	Homo sapiens	Q86UN6	Y2H Array	32296183
种属内	PRKAR2B	P31323	KIF5B	Homo sapiens	P33176	Validated Y2H	32296183
种属内	PRKAR2B	P31323	PRKACA	Homo sapiens	P17612	Anti Tag CoIP	33961781
种属内	PRKAR2B	P31323	PRKACA	Homo sapiens	P17612	Anti Tag CoIP	25477193
种属内	PRKAR2B	P31323	PRKACA	Homo sapiens	P17612	Y2H Prey Pooling	32296183
种属内	PRKAR2B	P31323	PRKACA	Homo sapiens	P17612	Anti Tag CoIP	26496610
种属内	PRKAR2B	P31323	PRKACA	Homo sapiens	P17612	FRET	25477193
种属内	PRKAR2B	P31323	PRKACA	Homo sapiens	P17612	Y2H Array	32296183
种属内	PRKAR2B	P31323	PRKACA	Homo sapiens	P17612	Affinity Chrom	25477193
种属内	PRKAR2B	P31323	AKAP5	Homo sapiens	P24588	Anti Tag CoIP	28514442
种属内	PRKAR2B	P31323	AKAP5	Homo sapiens	P24588	Y2H Array	32296183
种属内	PRKAR2B	P31323	AKAP5	Homo sapiens	P24588	Y2H Prey Pooling	32296183
种属内	PRKAR2B	P31323	AKAP5	Homo sapiens	P24588	Anti Tag CoIP	33961781
种属内	PRKAR2B	P31323	C2orf88	Homo sapiens	Q9BSF0	Y2H Array	32296183
种属内	PRKAR2B	P31323	C2orf88	Homo sapiens	Q9BSF0	Y2H Prey Pooling	32296183
种属内	PRKAR2B	P31323	C2orf88	Homo sapiens	Q9BSF0	Validated Y2H	32296183
种属内	PRKAR2B	P31323	ECM1	Homo sapiens	Q16610	Y2H Array	32296183
种属内	PRKAR2B	P31323	ECM1	Homo sapiens	Q16610	Validated Y2H	32296183
种属内	PRKAR2B	P31323	ECM1	Homo sapiens	Q16610	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Primary Pigmented Nodular Adrenocortical Disease

Ppnad	Primary Pigmented Nodular Adrenal Dysplasia
Pigmented Nodular Adrenocortical Disease, Primary, 2	Pigmented Nodular Adrenocortical Disease, Primary, 1

Carney Complex Variant

Carney Complex	Carney Syndrome
Carney Complex, Type 1	Lamb Syndrome
Name Syndrome	Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome
Carney Complex - Trismus - Pseudocamptodactyly Syndrome	Carney Complex, Type 2
Car	Cnc1
Carney Myxoma-Endocrine Complex	Myxoma - Spotty Pigmentation - Endocrine Overactivity
Myxoma, Spotty Pigmentation, And Endocrine Overactivity	Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome
Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome	Carney Complex-Trismus-Pseudocamptodactyly Syndrome
CACOV

Fibrolamellar Carcinoma

Fibrolamellar Hepatocellular Carcinoma	Fhcc
Fibrolamellar Hepatocarcinoma	Hepatocellular Carcinoma, Fibrolamellar
Oncocytic Hepatocellular Tumor	Eosinophilic Glassy Cell Hepatoma
Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis	Fl-Hcc
Fibrolamellar Oncocytic Hepatoma	Hepatocellular Carcinoma With Increased Stromal Fibrosis
Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma

Spinocerebellar Ataxia, Autosomal Recessive 16

Autosomal Recessive Spinocerebellar Ataxia 16	SCAR16
Autosomal Recessive Cerebellar Ataxia Due To Stub1 Deficiency	Spinocerebellar Ataxia Autosomal Recessive Type 16
Spinocerebellar Ataxia, Autosomal Recessive, 16	Ataxia, Spinocerebellar, Autosomal Recessive, Type 16

Acrodysostosis

Acrodysplasia	Arkless-Graham Syndrome
Maroteaux-Malamut Syndrome	Nasal Hypoplasia-Peripheral Dysostosis-Intellectual Disability Syndrome
Peripheral Dysostosis-Nasal Hypoplasia-Intellectual Disability Syndrome

Acth-Independent Macronodular Adrenal Hyperplasia

Acth-Independent Macronodular Adrenocortical Hyperplasia	Adrenocorticotropic Hormone-Independent Macronodular Adrenal Hyperplasia
Corticotropin-Independent Macronodular Adrenal Hyperplasia	Cushing Syndrome Due To Macronodular Adrenal Hyperplasia
AIMAH1	Aimah
Massive Macronodular Adrenocortical Disease	Mmad
Primary Macronodular Adrenal Hyperplasia	Cushing Syndrome, Adrenal, Due To Aimah
Primary Bilateral Macronodular Adrenal Hyperplasia	Acth-Independent Macronodular Adrenal Hyperplasia 1
Acth-Independent Cushing Syndrome	Adrenal Cushing Syndrome Due To Aimah
Acth-Independent Macronodular Adrenal Hyperplasia 2

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11115	PRKAR2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	PRKAR2B	VGNC	VGNC:69054
Canis familiaris	PRKAR2B	VGNC	VGNC:44977
Rattus norvegicus	PRKAR2B	RGD	RGD:3394
Macaca mulatta	PRKAR2B	VGNC	VGNC:76408
Mus musculus	PRKAR2B	MGD	MGI:97760
Bos taurus	PRKAR2B	VGNC	VGNC:33326

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PRKAR2B - protein kinase cAMP-dependent type II regulatory subunit beta Gene

关于 PRKAR2B

功能概要

PRKAR2B 基因产物(1)

PRKAR2B 蛋白结构

PRKAR2B 蛋白互作信息

关联疾病

直系同源

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PRKAR2B - protein kinase cAMP-dependent type II regulatory subunit beta Gene

关于 PRKAR2B

功能概要

PRKAR2B 基因产物(1)

PRKAR2B 蛋白结构

PRKAR2B 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z