TAF12 - TATA-box binding protein associated factor 12 Gene

中文名称：TATA-box 结合蛋白相关因子 12

种属: Homo sapiens

同用名: TAF2J; TAFII20

关于 TAF12

功能概要

RNA 聚合酶 II 对转录的控制涉及作为蛋白质集合的基础转录机制。这些蛋白质与 RNA 聚合酶 II 组装成复合物，这些复合物由反式激活蛋白调节，反式激活蛋白与位于转录起始位点附近的顺式调节元件结合。一些调节剂直接与基础复合物相互作用，而其他调节剂可能充当连接反式激活因子和基础转录因子的桥接蛋白。这些相关因素中的一些与 TFIID 复合体中的 TBP 紧密相关，而其他因素则与 TFIID 复合体中的 TBP 紧密相关。后者包括 TAF 蛋白。预计不同的 TAF 会介导多种基因启动子和 RNA 聚合酶的不同转录激活因子的功能。 TAF12 直接与 TBP 以及 TAF2I 相互作用。已发现该基因编码相同蛋白质的两个转录变体。[RefSeq 提供，2008 年 9 月]

Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas Others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while Others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2008]