TAF4 - TATA-box binding protein associated factor 4 Gene

中文名称：TATA-box 结合蛋白相关因子 4

种属: Homo sapiens

同用名: TAF2C; TAF4A; TAF2C1; TAFII130; TAFII135; TAFII-130; TAFII-135; TAF(II)130; TAF(II)135

关于 TAF4

功能概要

RNA 聚合酶 II 启动转录需要 70 多种多肽的活性。协调这些活动的蛋白质是转录因子 IID (TFIID) ，它与核心启动子结合以正确定位聚合酶，充当组装转录复合物其余部分的支架，并充当调节信号的通道。 TFIID 由 TATA 结合蛋白 (TBP) 和一组称为 TBP 相关因子或 TAF 的进化保守蛋白组成。 TAF 可能参与基础转录，充当共激活因子，在启动子识别中发挥作用或修饰一般转录因子 (GTF) 以促进复杂的组装和转录起始。该基因编码 TFIID 的较大亚基之一，该亚基已被证明可增强视黄酸、甲状腺激素和维生素 D3 受体的转录激活。此外，该亚基与具有富含谷氨酰胺激活结构域的转录因子 CREB 相互作用，并与其他含有富含谷氨酰胺区域的蛋白质结合。具有扩展的聚谷氨酰胺区域的蛋白质与该亚基的异常结合已被认为是一组称为聚谷氨酰胺疾病的神经退行性疾病的发病机制之一。[RefSeq 提供，2008 年 7 月]

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to Other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq, Jul 2008]