CREB3 - cAMP responsive element binding protein 3 Gene

中文名称：cAMP 反应元件结合蛋白 3

种属: Homo sapiens

同用名: LZIP; LUMAN; sLZIP

基因 ID: 10488 | 基因类型: protein coding

关于 CREB3

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:35,732,666-35,736,999 (from NCBI)

This gene has 2 transcripts (splice variants), 176 orthologues and 9 paralogues. Ubiquitous expression in prostate (RPKM 27.8), testis (RPKM 25.9) and 25 other tissues.

功能概要

该基因编码的转录因子是 DNA 结合蛋白亮氨酸拉链家族的成员。这种蛋白质与 cAMP 反应元件结合并调节细胞增殖。该蛋白与宿主细胞因子 C1 相互作用，后者还与诱导 HSV 立即早期基因转录的单纯疱疹病毒 (HSV) 蛋白 VP16 相关联。这种蛋白质和 VP16 都与宿主细胞因子 C1 上的相同位点结合。据认为，这种蛋白质与宿主细胞因子 C1 之间的相互作用在 HSV 感染期间潜伏期的建立中起作用。这种蛋白质还在白细胞迁移、肿瘤抑制和内质网应激相关蛋白质降解中发挥作用。已确定其他转录本变体，但尚未确定其生物学有效性。[RefSeq 提供，2009 年 11 月]

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV Infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]

CREB3 基因产物(1)

mRNA	Protein	Name
NM_006368.5	NP_006359.3	cyclic AMP-responsive element-binding protein 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables CCR1 chemokine receptor binding	IDA IDA: 通过直接分析推断	15001559	GOA
enables DNA binding	IDA IDA: 通过直接分析推断	9271389	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	16940180	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: 通过突变表型推断	16940180	GOA
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	10675342	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	16940180	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	16940180	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	15845366	GOA
enables cAMP response element binding protein binding	IDA IDA: 通过直接分析推断	9271389	GOA
enables chromatin binding	IDA IDA: 通过直接分析推断	16940180	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	21516116	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9271389	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	10675342	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA
enables transcription coregulator binding	IPI IPI: 通过物理相互作用推断	11711630	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA-templated transcription	IDA IDA: 通过直接分析推断	9271389	GOA
involved in cytoplasmic sequestering of transcription factor	IDA IDA: 通过直接分析推断	20091349	GOA
involved in endoplasmic reticulum unfolded protein response	IDA IDA: 通过直接分析推断	16940180	GOA
involved in establishment of viral latency	IDA IDA: 通过直接分析推断	20091349	GOA
NOT involved in induction of positive chemotaxis	IDA IDA: 通过直接分析推断	19779205	GOA
involved in induction of positive chemotaxis	IDA IDA: 通过直接分析推断	19779205	GOA
involved in induction of positive chemotaxis	IMP IMP: 通过突变表型推断	15001559	GOA
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IDA IDA: 通过直接分析推断	16940180	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	9271389	GOA
involved in positive regulation of calcium ion transport	IMP IMP: 通过突变表型推断	15001559	GOA
involved in positive regulation of cell migration	IMP IMP: 通过突变表型推断	15001559	GOA
involved in positive regulation of deacetylase activity	IDA IDA: 通过直接分析推断	19779205	GOA
involved in positive regulation of defense response to virus by host	IDA IDA: 通过直接分析推断	20091349	GOA
involved in positive regulation of monocyte chemotaxis	IDA IDA: 通过直接分析推断	17296613	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	15845366	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	16940180	GOA
involved in regulation of apoptotic process	IDA IDA: 通过直接分析推断	16940180	GOA
involved in regulation of cell growth	IDA IDA: 通过直接分析推断	20141198	GOA
involved in regulation of cell population proliferation	IMP IMP: 通过突变表型推断	10675342	GOA
involved in release from viral latency	IDA IDA: 通过直接分析推断	20091349	GOA
NOT involved in response to endoplasmic reticulum stress	IDA IDA: 通过直接分析推断	15845366	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IMP IMP: 通过突变表型推断	10623756	GOA
located in Golgi membrane	IDA IDA: 通过直接分析推断	20091349	GOA
part of RNA polymerase II transcription regulator complex	IPI IPI: 通过物理相互作用推断	20102225	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	18391022	GOA
located in cytoplasm	IMP IMP: 通过突变表型推断	10623756	GOA
located in cytosol	IMP IMP: 通过突变表型推断	15001559	GOA
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	16236796	GOA
located in endoplasmic reticulum	IMP IMP: 通过突变表型推断	10623756	GOA
located in endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	20091349	GOA
NOT located in membrane	IDA IDA: 通过直接分析推断	19779205	GOA
located in membrane	IDA IDA: 通过直接分析推断	10623756	GOA
located in neuronal cell body	IDA IDA: 通过直接分析推断	20091349	GOA
located in nuclear body	IDA IDA: 通过直接分析推断	18391022	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10675342	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CREB3 蛋白结构

bZIP_1

0
100
200
300
371 a.a.

蛋白主名

其他名称

cyclic AMP-responsive element-binding protein 3

basic leucine zipper protein

CREB3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	CREB3	O43889	ALG3	Homo sapiens	Q92685	Y2H Array	31515488
Intra	CREB3	O43889	HCFC1	Homo sapiens	P51610	Anti Tag CoIP	33961781
Intra	CREB3	O43889	HCFC1	Homo sapiens	P51610	Anti Bait CoIP	15705566
Intra	CREB3	O43889	CREB3L3	Homo sapiens	Q68CJ9	Peptide Array	20102225
Intra	CREB3	O43889	CREBZF	Homo sapiens	Q9NS37	Anti Bait CoIP	15705566
Intra	CREB3	O43889	CREB3	Homo sapiens	O43889	FRET	23661758
Intra	CREB3	O43889	CREB3	Homo sapiens	O43889	Y2H	21516116
Intra	CREB3	O43889	DDIT3	Homo sapiens	P35638	Peptide Array	20102225
Intra	CREB3	O43889	JUN	Homo sapiens	P05412	TAP	20195357

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Ventricular Tachycardia, Catecholaminergic Polymorphic, 2

Catecholaminergic Polymorphic Ventricular Tachycardia 2	CPVT2
Vtsip	Bidirectional Tachycardia
Stress-Induced Polymorphic Ventricular Tachycardia	Ventricular Tachycardia, Stress-Induced Polymorphic
Cvpt2	Double Tachycardia Induced By Catecholamines
Malignant Paroxysmal Ventricular Tachycardia	Multifocal Ventricular Premature Beats
Paroxysmal Ventricular Fibrillation	Syncopal Paroxysmal Tachycardia
Syncopal Tachyarythmia	Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 2
Ventricular Tachycardia, Catecholaminergic Polymorphic, 1	Multifocal Pvcs
Multifocal Premature Ventricular Beats	Paroxysmal Familial Ventricular Fibrillation

Microphthalmia

Microphthalmos	Isolated Anophthalmia-Microphthalmia Syndrome
Isolated Microphthalmia-Anophthalmia-Coloboma	Simple Microphthalmos
Clinical Anophthalmia	Isolated Anophthalmia - Microphthalmia
Isolated Pure Microphthalmia	Mac Spectrum
Microphthalmia-Anophthalmia-Coloboma Spectrum	Primitive Anophthalmia
Globe Of Eye Small	Small Eyeball
Hypoplasia Of Eye	Isolated Nanophthalmos
Rudimentary Eye	Dysplasia Of Eye

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03149	CREB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS03150	CREB3L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS03151	CREB3L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS03152	CREB3L3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS03153	CREB3L4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	CREB3	VGNC	VGNC:71486
Canis familiaris	CREB3	VGNC	VGNC:39596
Felis catus	CREB3	VGNC	VGNC:61165
Rattus norvegicus	CREB3	RGD	RGD:1308831
Mus musculus	CREB3	MGD	MGI:99946
Bos taurus	CREB3	VGNC	VGNC:27693
Others	CREB3	NCBI

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