1. Gene
  2. CREB3L3 - cAMP responsive element binding protein 3 like 3 Gene

CREB3L3 - cAMP responsive element binding protein 3 like 3 Gene

中文名称:cAMP 反应元件结合蛋白 3 like 3

种属: Homo sapiens

同用名: CREBH; HYTG2; CREB-H; HYST1481

基因 ID: 84699 | 基因类型: protein coding

关于 CREB3L3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,153,631-4,173,054 (from NCBI)

This gene has 5 transcripts (splice variants), 246 orthologues, 9 paralogues and is associated with 1 phenotype. Biased expression in small intestine (RPKM 71.0), duodenum (RPKM 67.5) and 1 other tissue.

功能概要

该基因编码碱性亮氨酸拉链家族和 AMP 依赖性转录因子家族的成员。编码的蛋白质定位于内质网,并充当由循环 AMP 刺激激活的转录因子。编码的蛋白质结合环 AMP 反应元件 (CRE) 和 box-B 元件,并与急性炎症反应、肝细胞癌、甘油三酯代谢和铁调素表达有关。可变剪接导致多个转录本变体。[RefSeq 提供,2012 年 12 月]

This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

CREB3L3 基因产物(4)

mRNA Protein Name
NM_001271995.2 NP_001258924.1 cyclic AMP-responsive element-binding protein 3-like protein 3 isoform b
NM_001271996.2 NP_001258925.1 cyclic AMP-responsive element-binding protein 3-like protein 3 isoform c
NM_001271997.2 NP_001258926.1 cyclic AMP-responsive element-binding protein 3-like protein 3 isoform d
NM_032607.3 NP_115996.1 cyclic AMP-responsive element-binding protein 3-like protein 3 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16469704 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
11353085 GOA
involved in response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
16469704 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
16236796 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16469704 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CREB3L3 蛋白结构

bZIP_1

bZIP_1: bZIP transcription factor (241 - 303)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 461 a.a.
蛋白主名 其他名称

cyclic AMP-responsive element-binding protein 3-like protein 3

CREB/ATF family transcription factor

CREB3L3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CREB3L3 Q68CJ9 CYB561A3 Homo sapiens Q8NBI2 32296183
种属内
CREB3L3 Q68CJ9 SLC38A7 Homo sapiens Q9NVC3 32296183
种属内
CREB3L3 Q68CJ9 TMEM239 Homo sapiens Q8WW34-2 32296183
种属内
CREB3L3 Q68CJ9 TCEANC Homo sapiens Q8N8B7-2 32296183
种属内
CREB3L3 Q68CJ9 SLC39A9 Homo sapiens Q9NUM3 32296183
种属内
CREB3L3 Q68CJ9 MCRS1 Homo sapiens Q96EZ8 32296183
种属内
CREB3L3 Q68CJ9 NFIL3 Homo sapiens Q16649 20102225
种属内
CREB3L3 Q68CJ9 CREB3 Homo sapiens O43889 23661758
种属内
CREB3L3 Q68CJ9 CREB3L1 Homo sapiens Q96BA8 23661758
种属内
CREB3L3 Q68CJ9 CEP19 Homo sapiens Q96LK0 32296183
种属内
CREB3L3 Q68CJ9 FATE1 Homo sapiens Q969F0 32296183
种属内
CREB3L3 Q68CJ9 SGTB Homo sapiens Q96EQ0 32296183
种属内
CREB3L3 Q68CJ9 DPY30 Homo sapiens Q9C005 32296183
种属内
CREB3L3 Q68CJ9 YIPF6 Homo sapiens Q96EC8 32296183
种属内
CREB3L3 Q68CJ9 TRAF3IP3 Homo sapiens Q9Y228 32296183
种属内
CREB3L3 Q68CJ9 RUSF1 Homo sapiens Q96GQ5 32296183
种属内
CREB3L3 Q68CJ9 CREB3L3 Homo sapiens Q68CJ9 23661758
种属内
CREB3L3 Q68CJ9 CREB3L3 Homo sapiens Q68CJ9 20102225
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hypertriglyceridemia 2

HYTG2

Hypertriglyceridemia 1

Hypertriglyceridemia

Hypertriglyceridemia, Familial

Hypertriglyceridemia, Susceptibility To

HYTG1

FHTR

Hypertriglyceridemias Familial

Platyspondylic Lethal Skeletal Dysplasia, Torrance Type

PLSD-T

PLSDT

Platyspondylic Dysplasia, Torrance Type

Lethal Short-Limbed Platyspondylic Dwarfism, Torrance Type

Thanatophoric Dysplasia, Torrance Variant

Platyspondylic Skeletal Dysplasia, Torrance Type

Torrance Type Platyspondylic Dysplasia

Platyspondylic Dysplasia, Torrance-Luton Type

Platyspondylic Lethal Skeletal Dysplasia Torrance Type

Lethal Short-Limbed Platyspondylic Dwarfism Torrance Type

Thanatophoric Dysplasia Torrance Variant

Platyspondylic Chondrodysplasia, Torrance-Luton Type

Plsd-Tl

Dysplasia, Skeletal, Platyspondylic, Torrance Type

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Osteogenesis Imperfecta, Type Xix

OI19

Osteogenesis Imperfecta Type 19

Osteogenesis Imperfecta Type Xix

Osteogenesis Imperfecta, Type 19

Osteogenesis Imperfecta 19

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CREB3L3 RGD RGD:1308152
Macaca mulatta CREB3L3 VGNC VGNC:109609
Canis familiaris CREB3L3 VGNC VGNC:54593
Mus musculus CREB3L3 MGD MGI:2384786
Bos taurus CREB3L3 VGNC VGNC:27696
Felis catus CREB3L3 VGNC VGNC:61168
我们的 Cookie 政策

我们使用 Cookies 和类似技术以提高网站的性能和提升您的浏览体验,部分功能也使用 Cookies 帮助我们更好地理解您的需求,为您提供相关的服务。 如果您有任何关于我们如何处理您个人信息的疑问,请阅读我们的《隐私声明》