2. Gene
  3. DPY30 - dpy-30 histone methyltransferase complex regulatory subunit Gene

DPY30 - dpy-30 histone methyltransferase complex regulatory subunit Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：dpy-30 组蛋白甲基转移酶复合调节亚基

种属: Homo sapiens

同用名: Cps25; Saf19; HDPY-30

基因 ID: 84661 | 基因类型: protein coding

关于 DPY30

Cytogenetic location: 2p22.3 Genomic coordinates (GRCh38): 2:32,011,649-32,039,835 (from NCBI)

This gene has 7 transcripts (splice variants) and 216 orthologues. Ubiquitous expression in thyroid (RPKM 7.5), adrenal (RPKM 7.3) and 25 other tissues.

功能概要

该基因编码 H3K4 甲基转移酶 SET1/MLL 家族的一个完整核心亚基。所编码的蛋白直接控制细胞周期调节因子，在人类造血祖细胞的增殖和分化中发挥重要作用。[RefSeq 提供，2016 年 3 月]

This gene encodes an integral core subunit of the SET1/MLL family of H3K4 methyltransferases. The encoded protein directly controls cell cycle regulators and plays an important role in the proliferation and differentiation of human hematopoietic progenitor cells. [provided by RefSeq, Mar 2016]

DPY30 基因产物(3)

mRNA Protein Name
NM_001321209.2 NP_001308138.1 protein dpy-30 homolog isoform 1
NM_001321210.2 NP_001308139.1 protein dpy-30 homolog isoform 2
NM_032574.4 NP_115963.1 protein dpy-30 homolog isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
19556245 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in endosomal transport IMP
IMP: 通过突变表型推断
19651892 GOA
involved in transcription initiation-coupled chromatin remodeling IDA
IDA: 通过直接分析推断
19556245 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of MLL1 complex IPI
IPI: 通过物理相互作用推断
23508102 GOA
part of MLL1/2 complex IPI
IPI: 通过物理相互作用推断
23508102 GOA
part of MLL3/4 complex IDA
IDA: 通过直接分析推断
17500065 GOA
part of MLL3/4 complex IPI
IPI: 通过物理相互作用推断
23508102 GOA
part of Set1C/COMPASS complex IDA
IDA: 通过直接分析推断
18838538 GOA
part of Set1C/COMPASS complex IPI
IPI: 通过物理相互作用推断
23508102 GOA
part of histone methyltransferase complex IDA
IDA: 通过直接分析推断
17500065 GOA
located in nucleus IDA
IDA: 通过直接分析推断
17500065 GOA
located in trans-Golgi network IDA
IDA: 通过直接分析推断
19651892 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DPY30 蛋白结构

Dpy-30

Dpy-30: Dpy-30 motif (52 - 92)

  • 0
  • 99 a.a.
蛋白主名 其他名称

protein dpy-30 homolog

dpy-30 homolog

DPY30 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DPY30 Q9C005 PXN Homo sapiens P49023-2
Y2H Prey Pooling
32296183
Intra DPY30 Q9C005 PXN Homo sapiens P49023-2
Y2H Array
32296183
Intra DPY30 Q9C005 GTF2I Homo sapiens P78347-2
Y2H Prey Pooling
32296183
Intra DPY30 Q9C005 GTF2I Homo sapiens P78347-2
Y2H Array
32296183
Intra DPY30 Q9C005 GPATCH2 Homo sapiens Q9NW75-2
Y2H Prey Pooling
32296183
Intra DPY30 Q9C005 GPATCH2 Homo sapiens Q9NW75-2
Validated Y2H
32296183
Intra DPY30 Q9C005 GPATCH2 Homo sapiens Q9NW75-2
Y2H Array
32296183
Intra DPY30 Q9C005 BEND3 Homo sapiens Q5T5X7
Y2H Prey Pooling
32296183
Intra DPY30 Q9C005 BEND3 Homo sapiens Q5T5X7
Y2H Array
32296183
Intra DPY30 Q9C005 ICA1L Homo sapiens Q8NDH6-2
Y2H Prey Pooling
32296183
Intra DPY30 Q9C005 ICA1L Homo sapiens Q8NDH6-2
Y2H Array
32296183
Intra DPY30 Q9C005 AKAP8 Homo sapiens O43823
Anti Tag CoIP
23995757
Intra DPY30 Q9C005 AKAP8 Homo sapiens O43823
Anti Bait CoIP
23995757
Intra DPY30 Q9C005 TSPY2 Homo sapiens A6NKD2
Y2H Prey Pooling
32296183
Intra DPY30 Q9C005 TSPY2 Homo sapiens A6NKD2
Y2H Array
32296183
Intra DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3-3
Filter Binding
25456412
Intra DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3-3
GMS
25456412
Intra DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3-3
X-Ray Diffraction
25456412
Intra DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3-3
Pull Down
25456412
Intra DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3-3
GMS
31485071
Intra DPY30 Q9C005 TSPY10 Homo sapiens P0CW01
Y2H Array
32296183
Intra DPY30 Q9C005 TSPY10 Homo sapiens P0CW01
Y2H Prey Pooling
32296183
Intra DPY30 Q9C005 CFAP91 Homo sapiens Q7Z4T9
Y2H Prey Pooling
32296183
Intra DPY30 Q9C005 CFAP91 Homo sapiens Q7Z4T9
Y2H Array
32296183
Intra DPY30 Q9C005 PSMC3 Homo sapiens P17980
Y2H Array
32296183
Intra DPY30 Q9C005 PSMC3 Homo sapiens P17980
Y2H Prey Pooling
32296183
Intra DPY30 Q9C005 FAM136A Homo sapiens Q96C01
Y2H Prey Pooling
32296183
Intra DPY30 Q9C005 FAM136A Homo sapiens Q96C01
Y2H Array
32296183
Intra DPY30 Q9C005 BAP18 Homo sapiens Q8IXM2
Pull Down
25456412
Intra DPY30 Q9C005 BAP18 Homo sapiens Q8IXM2
Anti Tag CoIP
25456412
Intra DPY30 Q9C005 BAP18 Homo sapiens Q8IXM2
Anti Tag CoIP
23995757
Intra DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Anti Tag CoIP
17500065
Intra DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Anti Tag CoIP
25456412
Intra DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Anti Tag CoIP
23995757
Intra DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Y2H Array
31515488
Intra DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Validated Y2H
32296183
Intra DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Pull Down
17500065
Intra DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Y2H Array
32296183
Intra DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Y2H Fragment Pooling
23414517
Intra DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Y2H Prey Pooling
25416956
Intra DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Y2H Array
25416956
Intra DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Solution Sedimentation
19556245
Intra DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Y2H Prey Pooling
32296183
Intra DPY30 Q9C005 ASH2L Homo sapiens Q9UBL3
Y2H
21516116
Intra DPY30 Q9C005 ZFYVE19 Homo sapiens Q96K21
Y2H Array
32296183
Intra DPY30 Q9C005 ZFYVE19 Homo sapiens Q96K21
Y2H Prey Pooling
32296183
Intra DPY30 Q9C005 RSPH3 Homo sapiens Q86UC2
Y2H Prey Pooling
32296183
Intra DPY30 Q9C005 RSPH3 Homo sapiens Q86UC2
Y2H Array
32296183
Intra DPY30 Q9C005 PSMD14 Homo sapiens O00487
Validated Y2H
25416956
Intra DPY30 Q9C005 PSMD14 Homo sapiens O00487
Y2H Prey Pooling
32296183
Intra DPY30 Q9C005 PSMD14 Homo sapiens O00487
Y2H Prey Pooling
25416956
Intra DPY30 Q9C005 PSMD14 Homo sapiens O00487
Y2H Array
32296183
Intra DPY30 Q9C005 DYDC1 Homo sapiens Q8WWB3
Y2H Array
32296183
Intra DPY30 Q9C005 DYDC1 Homo sapiens Q8WWB3
Y2H Pooling
16189514
Intra DPY30 Q9C005 DYDC1 Homo sapiens Q8WWB3
Y2H Prey Pooling
32296183
Intra DPY30 Q9C005 DPY30 Homo sapiens Q9C005
Solution Sedimentation
19556245
Intra DPY30 Q9C005 DPY30 Homo sapiens Q9C005
Pull Down
16189514
Intra DPY30 Q9C005 DPY30 Homo sapiens Q9C005
Y2H Pooling
16189514
Intra DPY30 Q9C005 DYDC2 Homo sapiens Q96IM9
Y2H Prey Pooling
32296183
Intra DPY30 Q9C005 DYDC2 Homo sapiens Q96IM9
Y2H Array
32296183
Intra DPY30 Q9C005 AK8 Homo sapiens Q96MA6
Y2H Prey Pooling
32296183
Intra DPY30 Q9C005 AK8 Homo sapiens Q96MA6
Y2H Array
32296183
Intra DPY30 Q9C005 CREB3L3 Homo sapiens Q68CJ9
Y2H Prey Pooling
32296183
Intra DPY30 Q9C005 CREB3L3 Homo sapiens Q68CJ9
Y2H Array
32296183
Intra DPY30 Q9C005 MRFAP1 Homo sapiens Q9Y605
Y2H Prey Pooling
32296183
Intra DPY30 Q9C005 MRFAP1 Homo sapiens Q9Y605
Validated Y2H
32296183
Intra DPY30 Q9C005 MRFAP1 Homo sapiens Q9Y605
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Kabuki Syndrome 1

Kabuki Syndrome

Niikawa-Kuroki Syndrome

Kabuki Make-Up Syndrome

Kms

KABUK1

Kabuki Make Up Syndrome

Nks

Kabuki Makeup Syndrome

Kabuki Syndrome, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03978 DPY30 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus DPY30 VGNC VGNC:80086
Bos taurus DPY30 VGNC VGNC:50608
Mus musculus DPY30 MGD MGI:1913560
Rattus norvegicus DPY30 RGD RGD:708575
Canis familiaris DPY30 VGNC VGNC:49106
Macaca mulatta DPY30 VGNC VGNC:71898
Others DPY30 NCBI
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