DPY30 - dpy-30 histone methyltransferase complex regulatory subunit Gene

中文名称：dpy-30 组蛋白甲基转移酶复合调节亚基

种属: Homo sapiens

同用名: Cps25; Saf19; HDPY-30

基因 ID: 84661 | 基因类型: protein coding

关于 DPY30

Cytogenetic location: 2p22.3 Genomic coordinates (GRCh38): 2:32,011,649-32,039,835 (from NCBI)

This gene has 7 transcripts (splice variants) and 216 orthologues. Ubiquitous expression in thyroid (RPKM 7.5), adrenal (RPKM 7.3) and 25 other tissues.

功能概要

该基因编码 H3K4 甲基转移酶 SET1/MLL 家族的一个完整核心亚基。所编码的蛋白直接控制细胞周期调节因子，在人类造血祖细胞的增殖和分化中发挥重要作用。[RefSeq 提供，2016 年 3 月]

This gene encodes an integral core subunit of the SET1/MLL family of H3K4 methyltransferases. The encoded protein directly controls cell cycle regulators and plays an important role in the proliferation and differentiation of human hematopoietic progenitor cells. [provided by RefSeq, Mar 2016]

DPY30 基因产物(3)

mRNA	Protein	Name
NM_001321209.2	NP_001308138.1	protein dpy-30 homolog isoform 1
NM_001321210.2	NP_001308139.1	protein dpy-30 homolog isoform 2
NM_032574.4	NP_115963.1	protein dpy-30 homolog isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	19556245	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in endosomal transport	IMP IMP: 通过突变表型推断	19651892	GOA
involved in transcription initiation-coupled chromatin remodeling	IDA IDA: 通过直接分析推断	19556245	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of MLL1 complex	IPI IPI: 通过物理相互作用推断	23508102	GOA
part of MLL1/2 complex	IPI IPI: 通过物理相互作用推断	23508102	GOA
part of MLL3/4 complex	IDA IDA: 通过直接分析推断	17500065	GOA
part of MLL3/4 complex	IPI IPI: 通过物理相互作用推断	23508102	GOA
part of Set1C/COMPASS complex	IDA IDA: 通过直接分析推断	18838538	GOA
part of Set1C/COMPASS complex	IPI IPI: 通过物理相互作用推断	23508102	GOA
part of histone methyltransferase complex	IDA IDA: 通过直接分析推断	17500065	GOA
located in nucleus	IDA IDA: 通过直接分析推断	17500065	GOA
located in trans-Golgi network	IDA IDA: 通过直接分析推断	19651892	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DPY30 蛋白结构

Dpy-30

0
99 a.a.

蛋白主名

其他名称

protein dpy-30 homolog

dpy-30 homolog

DPY30 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DPY30	Q9C005	PXN	Homo sapiens	P49023-2	Y2H Prey Pooling	32296183
种属内	DPY30	Q9C005	PXN	Homo sapiens	P49023-2	Y2H Array	32296183
种属内	DPY30	Q9C005	GTF2I	Homo sapiens	P78347-2	Y2H Prey Pooling	32296183
种属内	DPY30	Q9C005	GTF2I	Homo sapiens	P78347-2	Y2H Array	32296183
种属内	DPY30	Q9C005	GPATCH2	Homo sapiens	Q9NW75-2	Y2H Prey Pooling	32296183
种属内	DPY30	Q9C005	GPATCH2	Homo sapiens	Q9NW75-2	Validated Y2H	32296183
种属内	DPY30	Q9C005	GPATCH2	Homo sapiens	Q9NW75-2	Y2H Array	32296183
种属内	DPY30	Q9C005	BEND3	Homo sapiens	Q5T5X7	Y2H Prey Pooling	32296183
种属内	DPY30	Q9C005	BEND3	Homo sapiens	Q5T5X7	Y2H Array	32296183
种属内	DPY30	Q9C005	ICA1L	Homo sapiens	Q8NDH6-2	Y2H Prey Pooling	32296183
种属内	DPY30	Q9C005	ICA1L	Homo sapiens	Q8NDH6-2	Y2H Array	32296183
种属内	DPY30	Q9C005	AKAP8	Homo sapiens	O43823	Anti Tag CoIP	23995757
种属内	DPY30	Q9C005	AKAP8	Homo sapiens	O43823	Anti Bait CoIP	23995757
种属内	DPY30	Q9C005	TSPY2	Homo sapiens	A6NKD2	Y2H Prey Pooling	32296183
种属内	DPY30	Q9C005	TSPY2	Homo sapiens	A6NKD2	Y2H Array	32296183
种属内	DPY30	Q9C005	ASH2L	Homo sapiens	Q9UBL3-3	Filter Binding	25456412
种属内	DPY30	Q9C005	ASH2L	Homo sapiens	Q9UBL3-3	GMS	25456412
种属内	DPY30	Q9C005	ASH2L	Homo sapiens	Q9UBL3-3	X-Ray Diffraction	25456412
种属内	DPY30	Q9C005	ASH2L	Homo sapiens	Q9UBL3-3	Pull Down	25456412
种属内	DPY30	Q9C005	ASH2L	Homo sapiens	Q9UBL3-3	GMS	31485071
种属内	DPY30	Q9C005	TSPY10	Homo sapiens	P0CW01	Y2H Array	32296183
种属内	DPY30	Q9C005	TSPY10	Homo sapiens	P0CW01	Y2H Prey Pooling	32296183
种属内	DPY30	Q9C005	CFAP91	Homo sapiens	Q7Z4T9	Y2H Prey Pooling	32296183
种属内	DPY30	Q9C005	CFAP91	Homo sapiens	Q7Z4T9	Y2H Array	32296183
种属内	DPY30	Q9C005	PSMC3	Homo sapiens	P17980	Y2H Array	32296183
种属内	DPY30	Q9C005	PSMC3	Homo sapiens	P17980	Y2H Prey Pooling	32296183
种属内	DPY30	Q9C005	FAM136A	Homo sapiens	Q96C01	Y2H Prey Pooling	32296183
种属内	DPY30	Q9C005	FAM136A	Homo sapiens	Q96C01	Y2H Array	32296183
种属内	DPY30	Q9C005	BAP18	Homo sapiens	Q8IXM2	Pull Down	25456412
种属内	DPY30	Q9C005	BAP18	Homo sapiens	Q8IXM2	Anti Tag CoIP	25456412
种属内	DPY30	Q9C005	BAP18	Homo sapiens	Q8IXM2	Anti Tag CoIP	23995757
种属内	DPY30	Q9C005	ASH2L	Homo sapiens	Q9UBL3	Anti Tag CoIP	17500065
种属内	DPY30	Q9C005	ASH2L	Homo sapiens	Q9UBL3	Anti Tag CoIP	25456412
种属内	DPY30	Q9C005	ASH2L	Homo sapiens	Q9UBL3	Anti Tag CoIP	23995757
种属内	DPY30	Q9C005	ASH2L	Homo sapiens	Q9UBL3	Y2H Array	31515488
种属内	DPY30	Q9C005	ASH2L	Homo sapiens	Q9UBL3	Validated Y2H	32296183
种属内	DPY30	Q9C005	ASH2L	Homo sapiens	Q9UBL3	Pull Down	17500065
种属内	DPY30	Q9C005	ASH2L	Homo sapiens	Q9UBL3	Y2H Array	32296183
种属内	DPY30	Q9C005	ASH2L	Homo sapiens	Q9UBL3	Y2H Fragment Pooling	23414517
种属内	DPY30	Q9C005	ASH2L	Homo sapiens	Q9UBL3	Y2H Prey Pooling	25416956
种属内	DPY30	Q9C005	ASH2L	Homo sapiens	Q9UBL3	Y2H Array	25416956
种属内	DPY30	Q9C005	ASH2L	Homo sapiens	Q9UBL3	Solution Sedimentation	19556245
种属内	DPY30	Q9C005	ASH2L	Homo sapiens	Q9UBL3	Y2H Prey Pooling	32296183
种属内	DPY30	Q9C005	ASH2L	Homo sapiens	Q9UBL3	Y2H	21516116
种属内	DPY30	Q9C005	ZFYVE19	Homo sapiens	Q96K21	Y2H Array	32296183
种属内	DPY30	Q9C005	ZFYVE19	Homo sapiens	Q96K21	Y2H Prey Pooling	32296183
种属内	DPY30	Q9C005	RSPH3	Homo sapiens	Q86UC2	Y2H Prey Pooling	32296183
种属内	DPY30	Q9C005	RSPH3	Homo sapiens	Q86UC2	Y2H Array	32296183
种属内	DPY30	Q9C005	PSMD14	Homo sapiens	O00487	Validated Y2H	25416956
种属内	DPY30	Q9C005	PSMD14	Homo sapiens	O00487	Y2H Prey Pooling	32296183
种属内	DPY30	Q9C005	PSMD14	Homo sapiens	O00487	Y2H Prey Pooling	25416956
种属内	DPY30	Q9C005	PSMD14	Homo sapiens	O00487	Y2H Array	32296183
种属内	DPY30	Q9C005	DYDC1	Homo sapiens	Q8WWB3	Y2H Array	32296183
种属内	DPY30	Q9C005	DYDC1	Homo sapiens	Q8WWB3	Y2H Pooling	16189514
种属内	DPY30	Q9C005	DYDC1	Homo sapiens	Q8WWB3	Y2H Prey Pooling	32296183
种属内	DPY30	Q9C005	DPY30	Homo sapiens	Q9C005	Solution Sedimentation	19556245
种属内	DPY30	Q9C005	DPY30	Homo sapiens	Q9C005	Pull Down	16189514
种属内	DPY30	Q9C005	DPY30	Homo sapiens	Q9C005	Y2H Pooling	16189514
种属内	DPY30	Q9C005	DYDC2	Homo sapiens	Q96IM9	Y2H Prey Pooling	32296183
种属内	DPY30	Q9C005	DYDC2	Homo sapiens	Q96IM9	Y2H Array	32296183
种属内	DPY30	Q9C005	AK8	Homo sapiens	Q96MA6	Y2H Prey Pooling	32296183
种属内	DPY30	Q9C005	AK8	Homo sapiens	Q96MA6	Y2H Array	32296183
种属内	DPY30	Q9C005	CREB3L3	Homo sapiens	Q68CJ9	Y2H Prey Pooling	32296183
种属内	DPY30	Q9C005	CREB3L3	Homo sapiens	Q68CJ9	Y2H Array	32296183
种属内	DPY30	Q9C005	MRFAP1	Homo sapiens	Q9Y605	Y2H Prey Pooling	32296183
种属内	DPY30	Q9C005	MRFAP1	Homo sapiens	Q9Y605	Validated Y2H	32296183
种属内	DPY30	Q9C005	MRFAP1	Homo sapiens	Q9Y605	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Kabuki Syndrome 1

Kabuki Syndrome	Niikawa-Kuroki Syndrome
Kabuki Make-Up Syndrome	Kms
KABUK1	Kabuki Make Up Syndrome
Nks	Kabuki Makeup Syndrome
Kabuki Syndrome, Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03978	DPY30 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	DPY30	VGNC	VGNC:80086
Bos taurus	DPY30	VGNC	VGNC:50608
Mus musculus	DPY30	MGD	MGI:1913560
Rattus norvegicus	DPY30	RGD	RGD:708575
Canis familiaris	DPY30	VGNC	VGNC:49106
Macaca mulatta	DPY30	VGNC	VGNC:71898
Others	DPY30	NCBI

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