MRFAP1 - Morf4 family associated protein 1 Gene

中文名称：Morf4 家族相关蛋白 1

种属: Homo sapiens

同用名: PGR1; PAM14

基因 ID: 93621 | 基因类型: protein coding

关于 MRFAP1

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:6,640,685-6,642,729 (from NCBI)

This gene has 4 transcripts (splice variants), 45 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 146.3), adrenal (RPKM 117.0) and 25 other tissues.

功能概要

该基因编码一种细胞内蛋白，该蛋白与 MORF4/MRG (4 号染色体上的死亡率因子/MORF4 相关基因) 家族成员和肿瘤抑制因子 Rb (视网膜母细胞瘤蛋白) 相互作用。该蛋白可能在衰老、细胞生长和永生化中发挥作用.可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 1 月]

This gene encodes an intracellular protein that interacts with members of the MORF4/MRG (mortality factor on chromosome 4/MORF4 related gene) family and the tumor suppressor Rb (retinoblastoma protein.) The protein may play a role in senescence, cell growth and immortalization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

MRFAP1 基因产物(2)

mRNA	Protein	Name
NM_001272053.2	NP_001258982.1	MORF4 family-associated protein 1 isoform a
NM_033296.3	NP_150638.1	MORF4 family-associated protein 1 isoform a

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	11500496	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MRFAP1 蛋白结构

MRFAP1

0
100
127 a.a.

蛋白主名

其他名称

MORF4 family-associated protein 1

Mof4 family associated protein 1

MRFAP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	MRFAP1	Q9Y605	GOLGA8F	Homo sapiens	Q08AF8	Y2H Prey Pooling	25416956
Intra	MRFAP1	Q9Y605	MORF4L1	Homo sapiens	Q9UBU8-2	Y2H Array	32296183
Intra	MRFAP1	Q9Y605	MORF4L1	Homo sapiens	Q9UBU8-2	SLC	27107012
Intra	MRFAP1	Q9Y605	MORF4L1	Homo sapiens	Q9UBU8-2	Y2H Prey Pooling	25416956
Intra	MRFAP1	Q9Y605	MORF4L1	Homo sapiens	Q9UBU8-2	Y2H Prey Pooling	32296183
Intra	MRFAP1	Q9Y605	MORF4L1	Homo sapiens	Q9UBU8-2	BFG-2H	27107012
Intra	MRFAP1	Q9Y605	DCDC2	Homo sapiens	Q9UHG0	Validated Y2H	25416956
Intra	MRFAP1	Q9Y605	DCDC2	Homo sapiens	Q9UHG0	Y2H Prey Pooling	25416956
Intra	MRFAP1	Q9Y605	C14orf93	Homo sapiens	Q9H972	Anti Tag CoIP	33961781
Intra	MRFAP1	Q9Y605	UQCC2	Homo sapiens	Q9BRT2	Y2H Prey Pooling	32296183
Intra	MRFAP1	Q9Y605	UQCC2	Homo sapiens	Q9BRT2	Y2H Array	32296183
Intra	MRFAP1	Q9Y605	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	MRFAP1	Q9Y605	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	MRFAP1	Q9Y605	TPM2	Homo sapiens	P07951-2	Y2H Prey Pooling	32296183
Intra	MRFAP1	Q9Y605	TPM2	Homo sapiens	P07951-2	Y2H Array	32296183
Intra	MRFAP1	Q9Y605	PSEN1	Homo sapiens	P49768-2	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	PSEN1	Homo sapiens	P49768-2	Y2H Pooling	32814053
Intra	MRFAP1	Q9Y605	PSEN1	Homo sapiens	P49768-2	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	GDAP1	Homo sapiens	Q8TB36	Y2H Pooling	32814053
Intra	MRFAP1	Q9Y605	GDAP1	Homo sapiens	Q8TB36	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	GDAP1	Homo sapiens	Q8TB36	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	TEX11	Homo sapiens	Q8IYF3-3	Y2H Prey Pooling	32296183
Intra	MRFAP1	Q9Y605	TEX11	Homo sapiens	Q8IYF3-3	Y2H Array	32296183
Intra	MRFAP1	Q9Y605	FCHSD2	Homo sapiens	O94868-3	Y2H Prey Pooling	32296183
Intra	MRFAP1	Q9Y605	FCHSD2	Homo sapiens	O94868-3	Y2H Array	32296183
Intra	MRFAP1	Q9Y605	TSC1	Homo sapiens	Q86WV8	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	TSC1	Homo sapiens	Q86WV8	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	TSC1	Homo sapiens	Q86WV8	Y2H Pooling	32814053
Intra	MRFAP1	Q9Y605	PRAP1	Homo sapiens	Q96NZ9	Y2H Prey Pooling	32296183
Intra	MRFAP1	Q9Y605	PRAP1	Homo sapiens	Q96NZ9	Y2H Array	32296183
Intra	MRFAP1	Q9Y605	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	MRFAP1	Q9Y605	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	TOR1A	Homo sapiens	O14656-2	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	TOR1A	Homo sapiens	O14656-2	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	TOR1A	Homo sapiens	O14656-2	Y2H Pooling	32814053
Intra	MRFAP1	Q9Y605	C3orf62	Homo sapiens	Q6ZUJ4	Validated Y2H	25416956
Intra	MRFAP1	Q9Y605	BRK1	Homo sapiens	Q8WUW1	Y2H Prey Pooling	32296183
Intra	MRFAP1	Q9Y605	BRK1	Homo sapiens	Q8WUW1	Y2H Array	32296183
Intra	MRFAP1	Q9Y605	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	MRFAP1	Q9Y605	CAVIN3	Homo sapiens	Q969G5	Anti Tag CoIP	33961781
Intra	MRFAP1	Q9Y605	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	MRFAP1	Q9Y605	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	MRFAP1	Q9Y605	MORF4L1	Homo sapiens	Q9UBU8	Y2H Array	25416956
Intra	MRFAP1	Q9Y605	MORF4L1	Homo sapiens	Q9UBU8	Anti Bait CoIP	17353931
Intra	MRFAP1	Q9Y605	MORF4L1	Homo sapiens	Q9UBU8	Anti Tag CoIP	33961781
Intra	MRFAP1	Q9Y605	MORF4L1	Homo sapiens	Q9UBU8	MAPPIT	25416956
Intra	MRFAP1	Q9Y605	MORF4L2	Homo sapiens	Q15014	Y2H Prey Pooling	25416956
Intra	MRFAP1	Q9Y605	MORF4L2	Homo sapiens	Q15014	Anti Bait CoIP	17353931
Intra	MRFAP1	Q9Y605	MORF4L2	Homo sapiens	Q15014	Anti Tag CoIP	33961781
Intra	MRFAP1	Q9Y605	MORF4L2	Homo sapiens	Q15014	Pull Down	14506250
Intra	MRFAP1	Q9Y605	MORF4L2	Homo sapiens	Q15014	MAPPIT	25416956
Intra	MRFAP1	Q9Y605	MORF4L2	Homo sapiens	Q15014	Anti Tag CoIP	25416956
Intra	MRFAP1	Q9Y605	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	MRFAP1	Q9Y605	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	MRFAP1	Q9Y605	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	MRFAP1	Q9Y605	PCBD2	Homo sapiens	Q9H0N5	Y2H Prey Pooling	32296183
Intra	MRFAP1	Q9Y605	PCBD2	Homo sapiens	Q9H0N5	Y2H Array	32296183
Intra	MRFAP1	Q9Y605	A2M	Homo sapiens	P01023	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
Intra	MRFAP1	Q9Y605	A2M	Homo sapiens	P01023	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	MRFAP1	Q9Y605	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	SUV39H2	Homo sapiens	Q9H5I1	Anti Tag CoIP	23455924
Intra	MRFAP1	Q9Y605	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Array	32296183
Intra	MRFAP1	Q9Y605	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Prey Pooling	25416956
Intra	MRFAP1	Q9Y605	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Prey Pooling	32296183
Intra	MRFAP1	Q9Y605	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	MRFAP1	Q9Y605	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	MRFAP1	Q9Y605	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08645	MRFAP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	MRFAP1	RGD	RGD:628631
Mus musculus	MRFAP1	MGD	MGI:1914818

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