CAVIN3 - caveolae associated protein 3 Gene

中文名称：细胞膜穴样内陷相关蛋白 3

种属: Homo sapiens

同用名: SRBC; HSRBC; PRKCDBP; cavin-3

基因 ID: 112464 | 基因类型: protein coding

关于 CAVIN3

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:6,318,946-6,320,501 (from NCBI)

This gene has 4 transcripts (splice variants), 266 orthologues and 3 paralogues. Broad expression in fat (RPKM 24.8), testis (RPKM 13.9) and 19 other tissues.

功能概要

由该基因编码的蛋白质被鉴定为蛋白激酶 C, delta (PRKCD) 的结合蛋白。该基因在培养细胞系中的表达受血清饥饿的强烈诱导。发现该蛋白的表达在各种癌细胞系中下调，表明该蛋白可能具有肿瘤抑制功能。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various Cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 2008]

CAVIN3 基因产物(1)

mRNA	Protein	Name
NM_145040.3	NP_659477.2	caveolae-associated protein 3

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	19262564	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in caveola	IDA IDA: 通过直接分析推断	19525939	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	24013648	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CAVIN3 蛋白结构

PTRF_SDPR

0
100
200
261 a.a.

蛋白主名

其他名称

caveolae-associated protein 3

protein kinase C delta binding protein

CAVIN3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CAVIN3	Q969G5	TIMM8A	Homo sapiens	O60220	Y2H Array	32296183
种属内	CAVIN3	Q969G5	TIMM8A	Homo sapiens	O60220	Y2H Prey Pooling	32296183
种属内	CAVIN3	Q969G5	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
种属内	CAVIN3	Q969G5	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
种属内	CAVIN3	Q969G5	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
种属内	CAVIN3	Q969G5	EPS15L1	Homo sapiens	Q9UBC2	Anti Tag CoIP	19262564
种属内	CAVIN3	Q969G5	CAVIN1	Homo sapiens	Q6NZI2	Anti Tag CoIP	24013648
种属内	CAVIN3	Q969G5	CAVIN1	Homo sapiens	Q6NZI2	Y2H Array	32296183
种属内	CAVIN3	Q969G5	CAVIN1	Homo sapiens	Q6NZI2	Y2H Prey Pooling	32296183
种属内	CAVIN3	Q969G5	NUP62	Homo sapiens	P37198	Y2H Prey Pooling	32296183
种属内	CAVIN3	Q969G5	NUP62	Homo sapiens	P37198	Y2H Array	32296183
种属内	CAVIN3	Q969G5	TPM3	Homo sapiens	P06753	Y2H Array	32296183
种属内	CAVIN3	Q969G5	TPM3	Homo sapiens	P06753	Y2H Prey Pooling	32296183
种属内	CAVIN3	Q969G5	GPRASP2	Homo sapiens	Q96D09	Validated Y2H	32296183
种属内	CAVIN3	Q969G5	GPRASP2	Homo sapiens	Q96D09	Y2H Array	32296183
种属内	CAVIN3	Q969G5	GPRASP2	Homo sapiens	Q96D09	Y2H Prey Pooling	32296183
种属内	CAVIN3	Q969G5	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
种属内	CAVIN3	Q969G5	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
种属内	CAVIN3	Q969G5	CAV1	Homo sapiens	Q03135	IF	19262564
种属内	CAVIN3	Q969G5	CAV1	Homo sapiens	Q03135	Anti Tag CoIP	19262564
种属内	CAVIN3	Q969G5	CAV1	Homo sapiens	Q03135	Anti Tag CoIP	24013648
种属内	CAVIN3	Q969G5	MAGEA11	Homo sapiens	P43364	Y2H Prey Pooling	32296183
种属内	CAVIN3	Q969G5	MAGEA11	Homo sapiens	P43364	Y2H Array	32296183
种属内	CAVIN3	Q969G5	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
种属内	CAVIN3	Q969G5	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
种属内	CAVIN3	Q969G5	CEP76	Homo sapiens	Q8TAP6	Y2H Prey Pooling	32296183
种属内	CAVIN3	Q969G5	CEP76	Homo sapiens	Q8TAP6	Y2H Array	32296183
种属内	CAVIN3	Q969G5	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Array	32296183
种属内	CAVIN3	Q969G5	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Prey Pooling	32296183
种属内	CAVIN3	Q969G5	MRFAP1L1	Homo sapiens	Q96HT8	Validated Y2H	32296183
种属内	CAVIN3	Q969G5	MRFAP1L1	Homo sapiens	Q96HT8	Validated Y2H	25416956
种属内	CAVIN3	Q969G5	MRFAP1	Homo sapiens	Q9Y605	Validated Y2H	32296183
种属内	CAVIN3	Q969G5	MRFAP1	Homo sapiens	Q9Y605	Y2H Prey Pooling	32296183
种属内	CAVIN3	Q969G5	MRFAP1	Homo sapiens	Q9Y605	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Lipodystrophy, Congenital Generalized, Type 4

Congenital Generalized Lipodystrophy Type 4	CGL4
Berardinelli-Seip Congenital Lipodystrophy, Type 4, With Muscular Dystrophy	Lipodystrophy, Berardinelli-Seip Congenital, Type 4, With Muscular Dystrophy
Berardinelli-Seip Congenital Lipodystrophy Type 4 With Muscular Dystrophy	Generalized Congenital Lipodystrophy With Myopathy
Congenital Generalised Lipodystrophy Type 4	Generalised Congenital Lipodystrophy Type 4
Generalised Congenital Lipodystrophy With Myopathy	Generalized Congenital Lipodystrophy Type 4
Gcl4	Congenital Generalized Lipodystrophy 4
Berardinelli-Seip Congenital Lipodystrophy Type 4

Extracranial Neuroblastoma

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01990	CAVIN3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	CAVIN3	VGNC	VGNC:70693
Rattus norvegicus	CAVIN3	RGD	RGD:628755
Mus musculus	CAVIN3	MGD	MGI:1923422
Bos taurus	CAVIN3	VGNC	VGNC:26804
Felis catus	CAVIN3	VGNC	VGNC:81912
Canis familiaris	CAVIN3	VGNC	VGNC:38755

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