2. Gene
  3. CEP76 - centrosomal protein 76 Gene

CEP76 - centrosomal protein 76 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：中心体蛋白 76

种属: Homo sapiens

同用名: C18orf9; HsT1705

基因 ID: 79959 | 基因类型: protein coding

关于 CEP76

This gene has 12 transcripts (splice variants), 207 orthologues and 2 paralogues. Broad expression in testis (RPKM 7.3), esophagus (RPKM 1.7) and 23 other tissues.

功能概要

该基因编码一种中心体蛋白，该蛋白通过将中心粒复制限制在每个细胞周期一次来调节中心粒扩增。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 12 月]

This gene encodes a centrosomal protein which regulates centriole amplification by limiting centriole duplication to once per cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

CEP76 基因产物(2)

mRNA Protein Name
NM_001271989.2 NP_001258918.1 centrosomal protein of 76 kDa isoform b
NM_024899.4 NP_079175.2 centrosomal protein of 76 kDa isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of centriole replication IMP
IMP: 通过突变表型推断
19460342 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centriole IDA
IDA: 通过直接分析推断
19460342 GOA
located in centrosome IDA
IDA: 通过直接分析推断
21399614 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
24421332 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CEP76 蛋白结构

CEP76-C2

CEP76-C2: CEP76 C2 domain (99 - 259)

  • 0
  • 200
  • 400
  • 600
  • 659 a.a.
蛋白主名 其他名称

centrosomal protein of 76 kDa

centrosomal protein 76kDa

CEP76 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CEP76 Q8TAP6 AKAP7 Homo sapiens O43687-2
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 AKAP7 Homo sapiens O43687-2
Validated Y2H
25416956
Intra CEP76 Q8TAP6 TTC21A Homo sapiens A0A0B4J1Y2
Y2H Array
25416956
Intra CEP76 Q8TAP6 TTC21A Homo sapiens A0A0B4J1Y2
Validated Y2H
25416956
Intra CEP76 Q8TAP6 ZNF85 Homo sapiens Q03923-3
Validated Y2H
25416956
Intra CEP76 Q8TAP6 FKBP1A Homo sapiens Q0VDC6
Y2H Array
32814053
Intra CEP76 Q8TAP6 FKBP1A Homo sapiens Q0VDC6
Validated Y2H
32814053
Intra CEP76 Q8TAP6 FKBP1A Homo sapiens Q0VDC6
Y2H Pooling
32814053
Intra CEP76 Q8TAP6 LATS1 Homo sapiens Q6PJG3
Validated Y2H
25416956
Intra CEP76 Q8TAP6 DZIP1L Homo sapiens Q8IYY4
Y2H Array
31515488
Intra CEP76 Q8TAP6 DZIP1L Homo sapiens Q8IYY4
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 DZIP1L Homo sapiens Q8IYY4
Validated Y2H
25416956
Intra CEP76 Q8TAP6 DZIP1L Homo sapiens Q8IYY4
Y2H Array
29892012
Intra CEP76 Q8TAP6 WDFY3 Homo sapiens Q8IZQ1-2
Y2H Array
25416956
Intra CEP76 Q8TAP6 NHLRC2 Homo sapiens Q8NBF2
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 NHLRC2 Homo sapiens Q8NBF2
Validated Y2H
25416956
Intra CEP76 Q8TAP6 CABP5 Homo sapiens Q9NP86
Y2H Array
29892012
Intra CEP76 Q8TAP6 CABP5 Homo sapiens Q9NP86
Y2H Array
31515488
Intra CEP76 Q8TAP6 CABP5 Homo sapiens Q9NP86
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 CABP5 Homo sapiens Q9NP86
Validated Y2H
25416956
Intra CEP76 Q8TAP6 CABP5 Homo sapiens Q9NP86
Validated Y2H
32296183
Intra CEP76 Q8TAP6 GDAP2 Homo sapiens Q9NXN4
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 GDAP2 Homo sapiens Q9NXN4
Validated Y2H
25416956
Intra CEP76 Q8TAP6 PATZ1 Homo sapiens Q9HBE1-4
Validated Y2H
32296183
Intra CEP76 Q8TAP6 CENPI Homo sapiens Q92674
Validated Y2H
32296183
Intra CEP76 Q8TAP6 KIAA0586 Homo sapiens Q9BVV6
Anti Bait CoIP
24421332
Intra CEP76 Q8TAP6 KIAA0586 Homo sapiens Q9BVV6
Anti Tag CoIP
24421332
Intra CEP76 Q8TAP6 NEK6 Homo sapiens Q9HC98-4
Validated Y2H
32296183
Intra CEP76 Q8TAP6 POM121 Homo sapiens Q96HA1-2
Validated Y2H
32296183
Intra CEP76 Q8TAP6 ZNF653 Homo sapiens Q96CK0
Validated Y2H
32296183
Intra CEP76 Q8TAP6 CSNK1G1 Homo sapiens Q9HCP0
Y2H Array
25416956
Intra CEP76 Q8TAP6 CSNK1G1 Homo sapiens Q9HCP0
Validated Y2H
25416956
Intra CEP76 Q8TAP6 ANKRD36 Homo sapiens A1A5B0
Validated Y2H
32296183
Intra CEP76 Q8TAP6 RNF128 Homo sapiens Q8TEB7
Validated Y2H
25416956
Intra CEP76 Q8TAP6 RNF128 Homo sapiens Q8TEB7
Validated Y2H
32296183
Intra CEP76 Q8TAP6 RNF128 Homo sapiens Q8TEB7
Y2H Array
25416956
Intra CEP76 Q8TAP6 KIAA1143 Homo sapiens Q96AT1
Validated Y2H
25416956
Intra CEP76 Q8TAP6 KIAA1143 Homo sapiens Q96AT1
Validated Y2H
32296183
Intra CEP76 Q8TAP6 KIAA1143 Homo sapiens Q96AT1
Y2H Array
25416956
Intra CEP76 Q8TAP6 KIAA1143 Homo sapiens Q96AT1
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 TUFT1 Homo sapiens Q9NNX1
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 TOB2 Homo sapiens Q14106
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 TOB2 Homo sapiens Q14106
Y2H Array
25416956
Intra CEP76 Q8TAP6 ZBTB4 Homo sapiens Q9P1Z0
Validated Y2H
32296183
Intra CEP76 Q8TAP6 PPIA Homo sapiens P62937-2
Validated Y2H
32814053
Intra CEP76 Q8TAP6 PPIA Homo sapiens P62937-2
Y2H Array
32814053
Intra CEP76 Q8TAP6 PPIA Homo sapiens P62937-2
Y2H Pooling
32814053
Intra CEP76 Q8TAP6 ZMAT2 Homo sapiens Q96NC0
Validated Y2H
25416956
Intra CEP76 Q8TAP6 ZMAT2 Homo sapiens Q96NC0
Y2H Array
25416956
Intra CEP76 Q8TAP6 SMG9 Homo sapiens Q9H0W8
Validated Y2H
32296183
Intra CEP76 Q8TAP6 PARD6B Homo sapiens Q9BYG5
Validated Y2H
25416956
Intra CEP76 Q8TAP6 PARD6B Homo sapiens Q9BYG5
Validated Y2H
32296183
Intra CEP76 Q8TAP6 PDRG1 Homo sapiens Q9NUG6
Validated Y2H
32296183
Intra CEP76 Q8TAP6 PLCB1 Homo sapiens Q9NQ66
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 PLCB1 Homo sapiens Q9NQ66
Validated Y2H
25416956
Intra CEP76 Q8TAP6 RPL9 Homo sapiens P32969
Validated Y2H
25416956
Intra CEP76 Q8TAP6 RPL9 Homo sapiens P32969
Y2H Array
25416956
Intra CEP76 Q8TAP6 RPL9 Homo sapiens P32969
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 YWHAG Homo sapiens P61981
Validated Y2H
32814053
Intra CEP76 Q8TAP6 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
Intra CEP76 Q8TAP6 YWHAG Homo sapiens P61981
Y2H Array
32814053
Intra CEP76 Q8TAP6 CAVIN3 Homo sapiens Q969G5
Validated Y2H
32296183
Intra CEP76 Q8TAP6 P4HB Homo sapiens P07237
Y2H Pooling
32814053
Intra CEP76 Q8TAP6 P4HB Homo sapiens P07237
Validated Y2H
32814053
Intra CEP76 Q8TAP6 P4HB Homo sapiens P07237
Y2H Array
32814053
Intra CEP76 Q8TAP6 KAT5 Homo sapiens Q92993
Validated Y2H
32814053
Intra CEP76 Q8TAP6 KAT5 Homo sapiens Q92993
Y2H Array
32814053
Intra CEP76 Q8TAP6 KAT5 Homo sapiens Q92993
Y2H Pooling
32814053
Intra CEP76 Q8TAP6 ASH2L Homo sapiens Q9UBL3
Validated Y2H
32296183
Intra CEP76 Q8TAP6 ASH2L Homo sapiens Q9UBL3
Y2H Prey Pooling
32296183
Intra CEP76 Q8TAP6 CIR1 Homo sapiens Q86X95
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 CIR1 Homo sapiens Q86X95
Validated Y2H
25416956
Intra CEP76 Q8TAP6 CIR1 Homo sapiens Q86X95
Y2H Array
25416956
Intra CEP76 Q8TAP6 FAM90A1 Homo sapiens Q86YD7
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 FAM90A1 Homo sapiens Q86YD7
Validated Y2H
25416956
Intra CEP76 Q8TAP6 TXNDC9 Homo sapiens O14530
Y2H Array
25416956
Intra CEP76 Q8TAP6 TXNDC9 Homo sapiens O14530
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 PIN1 Homo sapiens Q13526
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 PIN1 Homo sapiens Q13526
Y2H Array
25416956
Intra CEP76 Q8TAP6 PIN1 Homo sapiens Q13526
Validated Y2H
25416956
Intra CEP76 Q8TAP6 CUTC Homo sapiens Q9NTM9
Y2H Array
25416956
Intra CEP76 Q8TAP6 CUTC Homo sapiens Q9NTM9
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 CUTC Homo sapiens Q9NTM9
Validated Y2H
25416956
Intra CEP76 Q8TAP6 TSSC4 Homo sapiens Q9Y5U2
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 TSSC4 Homo sapiens Q9Y5U2
Validated Y2H
25416956
Intra CEP76 Q8TAP6 TSSC4 Homo sapiens Q9Y5U2
Y2H Array
25416956
Intra CEP76 Q8TAP6 CCDC92 Homo sapiens Q53HC0
Y2H Array
25416956
Intra CEP76 Q8TAP6 C22orf39 Homo sapiens Q6P5X5
Y2H Array
25416956
Intra CEP76 Q8TAP6 C22orf39 Homo sapiens Q6P5X5
Validated Y2H
25416956
Intra CEP76 Q8TAP6 HSPB7 Homo sapiens Q9UBY9
Validated Y2H
32296183
Intra CEP76 Q8TAP6 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra CEP76 Q8TAP6 DVL3 Homo sapiens Q92997
Validated Y2H
32296183
Intra CEP76 Q8TAP6 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra CEP76 Q8TAP6 L3MBTL2 Homo sapiens Q969R5
Validated Y2H
32296183
Intra CEP76 Q8TAP6 POM121 Homo sapiens Q96HA1
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 POM121 Homo sapiens Q96HA1
Validated Y2H
25416956
Intra CEP76 Q8TAP6 POM121 Homo sapiens Q96HA1
Y2H Array
25416956
Intra CEP76 Q8TAP6 RBM41 Homo sapiens Q96IZ5
Validated Y2H
32296183
Intra CEP76 Q8TAP6 TCF19 Homo sapiens Q9Y242
Validated Y2H
32296183
Intra CEP76 Q8TAP6 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra CEP76 Q8TAP6 RADIL Homo sapiens Q96JH8
Validated Y2H
25416956
Intra CEP76 Q8TAP6 MYOZ1 Homo sapiens Q9NP98
Validated Y2H
32296183
Intra CEP76 Q8TAP6 ZBTB24 Homo sapiens O43167
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 ZBTB24 Homo sapiens O43167
Validated Y2H
25416956
Intra CEP76 Q8TAP6 ZBTB24 Homo sapiens O43167
Y2H Array
25416956
Intra CEP76 Q8TAP6 BANP Homo sapiens Q8N9N5
Y2H Array
25416956
Intra CEP76 Q8TAP6 BANP Homo sapiens Q8N9N5
Validated Y2H
25416956
Intra CEP76 Q8TAP6 SALL2 Homo sapiens Q9Y467
Y2H Pooling
16189514
Intra CEP76 Q8TAP6 SALL2 Homo sapiens Q9Y467
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 SALL2 Homo sapiens Q9Y467
Validated Y2H
25416956
Intra CEP76 Q8TAP6 SALL2 Homo sapiens Q9Y467
Y2H Array
25416956
Intra CEP76 Q8TAP6 SH2D4A Homo sapiens Q9H788
Validated Y2H
25416956
Intra CEP76 Q8TAP6 SH2D4A Homo sapiens Q9H788
Y2H Array
25416956
Intra CEP76 Q8TAP6 SH2D4A Homo sapiens Q9H788
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Intra CEP76 Q8TAP6 CRYBA4 Homo sapiens P53673
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 CRYBA4 Homo sapiens P53673
Y2H Array
31515488
Intra CEP76 Q8TAP6 CRYBA4 Homo sapiens P53673
Validated Y2H
25416956
Intra CEP76 Q8TAP6 CRYBA4 Homo sapiens P53673
Y2H Array
25416956
Intra CEP76 Q8TAP6 EAF1 Homo sapiens Q96JC9
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 EAF1 Homo sapiens Q96JC9
Validated Y2H
25416956
Intra CEP76 Q8TAP6 EAF1 Homo sapiens Q96JC9
Y2H Array
25416956
Intra CEP76 Q8TAP6 KLHDC4 Homo sapiens Q8TBB5
Validated Y2H
25416956
Intra CEP76 Q8TAP6 KLHDC4 Homo sapiens Q8TBB5
Y2H Array
25416956
Intra CEP76 Q8TAP6 KLHDC4 Homo sapiens Q8TBB5
Y2H Prey Pooling
25416956
Intra CEP76 Q8TAP6 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Intra CEP76 Q8TAP6 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Intra CEP76 Q8TAP6 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Jawad Syndrome

JWDS

Kelly Syndrome

Microcephaly With Mental Retardation And Digital Anomalies

Kelly

Microcephaly-Digital Anomalies Syndrome

Plummer-Vinson Syndrome
Neu-Laxova Syndrome 2

NLS2
Nail Disorder, Nonsyndromic Congenital, 4

Anonychia Congenita

Anonychia

Hyponychia Congenita

NDNC4

Anonychia/Hyponychia Congenita

Nonsyndromic Congenital Nail Disorder 4

Isolated Congenital Anonychia

Anonychia Congenita Totalis

Anonychia Totalis

Autosomal Recessive Nonsyndromic Congenital Nail Disorder-4

Congenital Anonychia

Nonsyndromic Congenital Nail Disorder, 4

Absent Nails

Aplastic Nails

Congenital Absence Of Nails

Isolated Anonychia

Nail Disorder, Non-Syndromic Congenital, 4

Nail Disorder, Nonsyndromic, Congenital, Type 4
Nonsyndromic Congenital Nail Disorder

Nail Disorder, Nonsyndromic Congenital
Nephronophthisis 14

Joubert Syndrome 19

NPHP14

JBTS19

Nephronophthisis, Type 14
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02523 CEP76 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CEP76 VGNC VGNC:27213
Rattus norvegicus CEP76 RGD RGD:1305183
Canis familiaris CEP76 VGNC VGNC:39137
Felis catus CEP76 VGNC VGNC:60783
Macaca mulatta CEP76 VGNC VGNC:104217
Mus musculus CEP76 MGD MGI:1923401
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