2. Gene
  3. L3MBTL2 - L3MBTL histone methyl-lysine binding protein 2 Gene

L3MBTL2 - L3MBTL histone methyl-lysine binding protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：L3MBTL 组蛋白甲基赖氨酸结合蛋白 2

种属: Homo sapiens

同用名: L3MBT; H-l(3)mbt-l

基因 ID: 83746 | 基因类型: protein coding

关于 L3MBTL2

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:41,205,312-41,231,271 (from NCBI)

This gene has 9 transcripts (splice variants), 212 orthologues and 18 paralogues. Ubiquitous expression in lymph node (RPKM 7.9), testis (RPKM 7.9) and 25 other tissues.

功能概要

启用甲基化组蛋白结合活性。预测参与转录的负调控，DNA 模板化。预计在几个过程的上游或内部起作用，包括外胚层发育；组蛋白修饰的调节；和干细胞增殖。位于核内。 [由基因组资源联盟提供，2022 年 4 月]

Enables methylated histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including ectoderm development; regulation of histone modification; and stem cell proliferation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

L3MBTL2 基因产物(1)

mRNA Protein Name
NM_031488.5 NP_113676.2 lethal(3)malignant brain tumor-like protein 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone binding IPI
IPI: 通过物理相互作用推断
17540172 GOA
enables methylated histone binding IDA
IDA: 通过直接分析推断
19233876 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

L3MBTL2 蛋白结构

MBT

MBT: mbt repeat (214 - 287)

MBT

MBT: mbt repeat (327 - 389)

MBT

MBT: mbt repeat (432 - 508)

MBT

MBT: mbt repeat (540 - 604)

  • 0
  • 200
  • 400
  • 600
  • 705 a.a.
蛋白主名 其他名称

lethal(3)malignant brain tumor-like protein 2

H-l(3)mbt-like protein 2

L3MBTL2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra L3MBTL2 Q969R5 TEKT1 Homo sapiens Q969V4
Y2H Array
32296183
Intra L3MBTL2 Q969R5 TEKT1 Homo sapiens Q969V4
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 TEKT1 Homo sapiens Q969V4
Validated Y2H
32296183
Intra L3MBTL2 Q969R5 BEND7 Homo sapiens Q8N7W2-2
Y2H Prey Pooling
26871637
Intra L3MBTL2 Q969R5 BEND7 Homo sapiens Q8N7W2-2
Validated Y2H
26871637
Intra L3MBTL2 Q969R5 BEND7 Homo sapiens Q8N7W2-2
Y2H Array
26871637
Intra L3MBTL2 Q969R5 BEND7 Homo sapiens Q8N7W2-2
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 BEND7 Homo sapiens Q8N7W2-2
Y2H Array
32296183
Intra L3MBTL2 Q969R5 TBC1D9B Homo sapiens Q66K14-2
Validated Y2H
25416956
Intra L3MBTL2 Q969R5 TBC1D9B Homo sapiens Q66K14-2
Y2H Array
25416956
Intra L3MBTL2 Q969R5 TBC1D9B Homo sapiens Q66K14-2
Y2H Prey Pooling
25416956
Intra L3MBTL2 Q969R5 PHF10 Homo sapiens Q8WUB8-2
Y2H Prey Pooling
25416956
Intra L3MBTL2 Q969R5 PHF10 Homo sapiens Q8WUB8-2
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 PHF10 Homo sapiens Q8WUB8-2
Y2H Array
25416956
Intra L3MBTL2 Q969R5 PHF10 Homo sapiens Q8WUB8-2
Validated Y2H
25416956
Intra L3MBTL2 Q969R5 GAS8 Homo sapiens O95995
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 GAS8 Homo sapiens O95995
Y2H Array
32296183
Intra L3MBTL2 Q969R5 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra L3MBTL2 Q969R5 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 GPRASP3 Homo sapiens Q6PI77
Y2H Array
32296183
Intra L3MBTL2 Q969R5 GPRASP3 Homo sapiens Q6PI77
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 CARD9 Homo sapiens Q9H257-2
Validated Y2H
32296183
Intra L3MBTL2 Q969R5 CARD9 Homo sapiens Q9H257-2
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 CARD9 Homo sapiens Q9H257-2
Y2H Array
32296183
Intra L3MBTL2 Q969R5 NRF1 Homo sapiens Q16656-4
Y2H Array
32296183
Intra L3MBTL2 Q969R5 NRF1 Homo sapiens Q16656-4
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 ZNF467 Homo sapiens Q7Z7K2
Y2H Array
32296183
Intra L3MBTL2 Q969R5 ZNF467 Homo sapiens Q7Z7K2
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra L3MBTL2 Q969R5 RBAK Homo sapiens Q9NYW8
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 RBAK Homo sapiens Q9NYW8
Y2H Array
32296183
Intra L3MBTL2 Q969R5 RBAK Homo sapiens Q9NYW8
Validated Y2H
32296183
Intra L3MBTL2 Q969R5 TBC1D9B Homo sapiens A1L3A9
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 TBC1D9B Homo sapiens A1L3A9
Y2H Array
32296183
Intra L3MBTL2 Q969R5 BIVM Homo sapiens Q86UB2
Y2H Array
32296183
Intra L3MBTL2 Q969R5 BIVM Homo sapiens Q86UB2
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 SSUH2 Homo sapiens Q9Y2M2-2
Y2H Array
32296183
Intra L3MBTL2 Q969R5 SSUH2 Homo sapiens Q9Y2M2-2
Validated Y2H
32296183
Intra L3MBTL2 Q969R5 SSUH2 Homo sapiens Q9Y2M2-2
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 ZFY Homo sapiens P08048
Y2H Prey Pooling
26871637
Intra L3MBTL2 Q969R5 ZFY Homo sapiens P08048
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 ZFY Homo sapiens P08048
Validated Y2H
26871637
Intra L3MBTL2 Q969R5 ZFY Homo sapiens P08048
Y2H Array
26871637
Intra L3MBTL2 Q969R5 ZFY Homo sapiens P08048
Y2H Array
32296183
Intra L3MBTL2 Q969R5 ZNF829 Homo sapiens Q3KNS6-3
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 ZNF829 Homo sapiens Q3KNS6-3
Y2H Array
32296183
Intra L3MBTL2 Q969R5 FAM217B Homo sapiens Q9NTX9
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 FAM217B Homo sapiens Q9NTX9
Y2H Array
32296183
Intra L3MBTL2 Q969R5 FAM217B Homo sapiens Q9NTX9
Validated Y2H
32296183
Intra L3MBTL2 Q969R5 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 EFHC2 Homo sapiens Q5JST6
Y2H Array
32296183
Intra L3MBTL2 Q969R5 PRKAR1B Homo sapiens P31321
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 PRKAR1B Homo sapiens P31321
Y2H Array
32296183
Intra L3MBTL2 Q969R5 MEOX1 Homo sapiens P50221
Y2H Array
32296183
Intra L3MBTL2 Q969R5 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 EIF4ENIF1 Homo sapiens Q9NRA8
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 EIF4ENIF1 Homo sapiens Q9NRA8
Validated Y2H
32296183
Intra L3MBTL2 Q969R5 EIF4ENIF1 Homo sapiens Q9NRA8
Y2H Array
32296183
Intra L3MBTL2 Q969R5 STAM2 Homo sapiens O75886
Y2H Array
32296183
Intra L3MBTL2 Q969R5 STAM2 Homo sapiens O75886
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 ZBTB26 Homo sapiens Q9HCK0
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 ZBTB26 Homo sapiens Q9HCK0
Y2H Array
32296183
Intra L3MBTL2 Q969R5 ZBTB26 Homo sapiens Q9HCK0
Validated Y2H
32296183
Intra L3MBTL2 Q969R5 MEAF6 Homo sapiens Q9HAF1
Validated Y2H
32296183
Intra L3MBTL2 Q969R5 MEAF6 Homo sapiens Q9HAF1
Y2H Array
32296183
Intra L3MBTL2 Q969R5 TRIM42 Homo sapiens Q8IWZ5
Y2H Prey Pooling
25416956
Intra L3MBTL2 Q969R5 TRIM42 Homo sapiens Q8IWZ5
Validated Y2H
25416956
Intra L3MBTL2 Q969R5 TRIM42 Homo sapiens Q8IWZ5
Y2H Array
25416956
Intra L3MBTL2 Q969R5 TAX1BP1 Homo sapiens Q86VP1
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
32296183
Intra L3MBTL2 Q969R5 HDAC3 Homo sapiens O15379
Pull Down
20385135
Intra L3MBTL2 Q969R5 HDAC3 Homo sapiens O15379
Anti Bait CoIP
20385135
Intra L3MBTL2 Q969R5 HDAC3 Homo sapiens O15379
Anti Tag CoIP
20385135
Intra L3MBTL2 Q969R5 HDAC3 Homo sapiens O15379
Y2H
20385135
Intra L3MBTL2 Q969R5 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra L3MBTL2 Q969R5 CCDC106 Homo sapiens Q9BWC9
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 CCDC106 Homo sapiens Q9BWC9
Validated Y2H
32296183
Intra L3MBTL2 Q969R5 CCDC106 Homo sapiens Q9BWC9
Y2H Array
32296183
Intra L3MBTL2 Q969R5 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra L3MBTL2 Q969R5 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 ZFP64 Homo sapiens Q9NTW7
Y2H Prey Pooling
26871637
Intra L3MBTL2 Q969R5 ZFP64 Homo sapiens Q9NTW7
Validated Y2H
26871637
Intra L3MBTL2 Q969R5 ZFP64 Homo sapiens Q9NTW7
Y2H Array
26871637
Intra L3MBTL2 Q969R5 PAICS Homo sapiens P22234
Validated Y2H
25416956
Intra L3MBTL2 Q969R5 PAICS Homo sapiens P22234
Validated Y2H
26871637
Intra L3MBTL2 Q969R5 PAICS Homo sapiens P22234
Y2H Array
26871637
Intra L3MBTL2 Q969R5 PAICS Homo sapiens P22234
Y2H Prey Pooling
26871637
Intra L3MBTL2 Q969R5 TLE5 Homo sapiens Q08117
Y2H Prey Pooling
25416956
Intra L3MBTL2 Q969R5 TLE5 Homo sapiens Q08117
Validated Y2H
25416956
Intra L3MBTL2 Q969R5 TSPYL Homo sapiens Q6FI91
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 TSPYL Homo sapiens Q6FI91
Y2H Array
32296183
Intra L3MBTL2 Q969R5 THAP1 Homo sapiens Q9NVV9
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 THAP1 Homo sapiens Q9NVV9
Validated Y2H
32296183
Intra L3MBTL2 Q969R5 THAP1 Homo sapiens Q9NVV9
Y2H Array
32296183
Intra L3MBTL2 Q969R5 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 CEP76 Homo sapiens Q8TAP6
Y2H Array
32296183
Intra L3MBTL2 Q969R5 GKAP1 Homo sapiens Q5VSY0
Y2H Array
32296183
Intra L3MBTL2 Q969R5 GKAP1 Homo sapiens Q5VSY0
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 ZBTB48 Homo sapiens P10074
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 ZBTB48 Homo sapiens P10074
Y2H Array
32296183
Intra L3MBTL2 Q969R5 STAC3 Homo sapiens Q96MF2
Y2H Prey Pooling
26871637
Intra L3MBTL2 Q969R5 STAC3 Homo sapiens Q96MF2
Validated Y2H
26871637
Intra L3MBTL2 Q969R5 STAC3 Homo sapiens Q96MF2
Y2H Array
26871637
Intra L3MBTL2 Q969R5 STAC3 Homo sapiens Q96MF2
Validated Y2H
25416956
Intra L3MBTL2 Q969R5 TNNI1 Homo sapiens P19237
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 TNNI1 Homo sapiens P19237
Y2H Array
32296183
Intra L3MBTL2 Q969R5 AMOTL2 Homo sapiens Q9Y2J4
Validated Y2H
32296183
Intra L3MBTL2 Q969R5 AMOTL2 Homo sapiens Q9Y2J4
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 AMOTL2 Homo sapiens Q9Y2J4
Y2H Array
32296183
Intra L3MBTL2 Q969R5 MAX Homo sapiens P61244
Pull Down
25609649
Intra L3MBTL2 Q969R5 MAX Homo sapiens P61244
TAP
25609649
Intra L3MBTL2 Q969R5 MAX Homo sapiens P61244
Anti Tag CoIP
33961781
Intra L3MBTL2 Q969R5 MAX Homo sapiens P61244
TAP
24981860
Intra L3MBTL2 Q969R5 MAX Homo sapiens P61244
TAP
27705803
Intra L3MBTL2 Q969R5 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra L3MBTL2 Q969R5 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra L3MBTL2 Q969R5 TRIM50 Homo sapiens Q86XT4
Y2H Prey Pooling
32296183
Intra L3MBTL2 Q969R5 TRIM50 Homo sapiens Q86XT4
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Idh-Mutant Anaplastic Astrocytoma
Idh-Wildtype Anaplastic Astrocytoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07485 L3MBTL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris L3MBTL2 VGNC VGNC:42558
Felis catus L3MBTL2 VGNC VGNC:63182
Macaca mulatta L3MBTL2 VGNC VGNC:74074
Bos taurus L3MBTL2 VGNC VGNC:30763
Mus musculus L3MBTL2 MGD MGI:2443584
Rattus norvegicus L3MBTL2 RGD RGD:1308569
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z