EIF4ENIF1 - eukaryotic translation initiation factor 4E nuclear import factor 1 Gene

中文名称：真核翻译起始因子 4E 核输入因子 1

种属: Homo sapiens

同用名: 4E-T; Clast4

基因 ID: 56478 | 基因类型: protein coding

关于 EIF4ENIF1

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:31,436,963-31,493,568 (from NCBI)

This gene has 13 transcripts (splice variants), 209 orthologues and is associated with 1 phenotype. Broad expression in testis (RPKM 19.7), brain (RPKM 7.2) and 25 other tissues.

功能概要

该基因编码的蛋白质是翻译起始因子 eIF4E 的核质穿梭蛋白。这种穿梭蛋白与输入蛋白 alpha-beta 复合物相互作用，以介导 eIF4E 的核输入。它主要是细胞质的；其自身的核输入受核定位信号和核输出信号的控制。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2009 年 8 月]

The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

EIF4ENIF1 基因产物(3)

mRNA	Protein	Name
NM_001164501.2	NP_001157973.1	eukaryotic translation initiation factor 4E transporter isoform a
NM_001164502.2	NP_001157974.1	eukaryotic translation initiation factor 4E transporter isoform b
NM_019843.4	NP_062817.2	eukaryotic translation initiation factor 4E transporter isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables kinase binding	IPI IPI: 通过物理相互作用推断	22966201	GOA
enables nuclear export signal receptor activity	IDA IDA: 通过直接分析推断	10856257	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10856257	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in P-body assembly	IDA IDA: 通过直接分析推断	22966201	GOA
involved in P-body assembly	IMP IMP: 通过突变表型推断	16157702	GOA
involved in mRNA stabilization	IDA IDA: 通过直接分析推断	24335285	GOA
acts upstream of positive effect miRNA-mediated gene silencing by inhibition of translation	IDA IDA: 通过直接分析推断	24335285	GOA
involved in negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA	IDA IDA: 通过直接分析推断	32354837	GOA
involved in negative regulation of translation	IDA IDA: 通过直接分析推断	24335285	GOA
involved in negative regulation of translation	IMP IMP: 通过突变表型推断	16157702	GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IDA IDA: 通过直接分析推断	32354837	GOA
involved in protein import into nucleus	IDA IDA: 通过直接分析推断	28216671	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in P-body	IDA IDA: 通过直接分析推断	16157702	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	28216671	GOA
located in nucleus	IDA IDA: 通过直接分析推断	28216671	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EIF4ENIF1 蛋白结构

EIF4E-T

0
200
400
600
800
985 a.a.

蛋白主名

其他名称

eukaryotic translation initiation factor 4E transporter

2610509L04Rik

EIF4ENIF1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	EIF4ENIF1	Q9NRA8	EIF4E2	Homo sapiens	O60573-1	Anti Tag CoIP	28698298
种属内	EIF4ENIF1	Q9NRA8	EIF4E	Homo sapiens	P06730-1	Anti Tag CoIP	28698298
种属内	EIF4ENIF1	Q9NRA8	DDX6	Homo sapiens	P26196	BN-PAGE	26184334
种属内	EIF4ENIF1	Q9NRA8	HNRNPF	Homo sapiens	P52597	Validated Y2H	25416956
种属内	EIF4ENIF1	Q9NRA8	HNRNPF	Homo sapiens	P52597	Y2H Array	25416956
种属内	EIF4ENIF1	Q9NRA8	TXLNA	Homo sapiens	P40222	Validated Y2H	25416956
种属内	EIF4ENIF1	Q9NRA8	TXLNA	Homo sapiens	P40222	Y2H Array	25416956
种属内	EIF4ENIF1	Q9NRA8	TXLNA	Homo sapiens	P40222	Y2H Prey Pooling	25416956
种属内	EIF4ENIF1	Q9NRA8	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
种属内	EIF4ENIF1	Q9NRA8	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
种属内	EIF4ENIF1	Q9NRA8	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
种属内	EIF4ENIF1	Q9NRA8	OIP5	Homo sapiens	O43482	Validated Y2H	25416956
种属内	EIF4ENIF1	Q9NRA8	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	25416956
种属内	EIF4ENIF1	Q9NRA8	EIF4E	Homo sapiens	P06730	Y2H Array	25416956
种属内	EIF4ENIF1	Q9NRA8	EIF4E	Homo sapiens	P06730	Pull Down	10856257
种属内	EIF4ENIF1	Q9NRA8	EIF4E	Homo sapiens	P06730	Y2H Pooling	19060904
种属内	EIF4ENIF1	Q9NRA8	EIF4E	Homo sapiens	P06730	Validated Y2H	25416956
种属内	EIF4ENIF1	Q9NRA8	EIF4E	Homo sapiens	P06730	Y2H Array	19060904
种属内	EIF4ENIF1	Q9NRA8	EIF4E	Homo sapiens	P06730	Affinity Chrom	10856257
种属内	EIF4ENIF1	Q9NRA8	DTX2	Homo sapiens	Q86UW9	Validated Y2H	25416956
种属内	EIF4ENIF1	Q9NRA8	DTX2	Homo sapiens	Q86UW9	Y2H Array	25416956
种属内	EIF4ENIF1	Q9NRA8	KRT19	Homo sapiens	P08727	Y2H Prey Pooling	25416956
种属内	EIF4ENIF1	Q9NRA8	KRT19	Homo sapiens	P08727	Validated Y2H	25416956
种属内	EIF4ENIF1	Q9NRA8	EFHC1	Homo sapiens	Q5JVL4	Y2H Array	25416956
种属内	EIF4ENIF1	Q9NRA8	EFHC1	Homo sapiens	Q5JVL4	Y2H Prey Pooling	25416956
种属内	EIF4ENIF1	Q9NRA8	ATXN1	Homo sapiens	P54253	Y2H	16713569
种属内	EIF4ENIF1	Q9NRA8	TTC19	Homo sapiens	Q6DKK2	Validated Y2H	25416956
种属内	EIF4ENIF1	Q9NRA8	TTC19	Homo sapiens	Q6DKK2	Y2H Array	25416956
种属内	EIF4ENIF1	Q9NRA8	TTC19	Homo sapiens	Q6DKK2	Y2H Prey Pooling	25416956
种属间	EIF4ENIF1	Q9NRA8	Q9WMX2-PRO_0000037548	Hepatitis C virus	Q9WMX2-PRO_0000037548	Y2H	18985028
种属间	EIF4ENIF1	Q9NRA8	Q9WMX2-PRO_0000037548	Hepatitis C virus	Q9WMX2-PRO_0000037548	Y2H Prey Pooling	18985028
种属间	EIF4ENIF1	Q9NRA8	Q9WMX2-PRO_0000037548	Hepatitis C virus	Q9WMX2-PRO_0000037548	Pull Down	18985028

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Suppurative Lymphadenitis

Suppurative Lymphadenopathy

Thymus Lymphoma

Thymic Lymphoma

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04280	EIF4ENIF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	EIF4ENIF1	VGNC	VGNC:72054
Mus musculus	EIF4ENIF1	MGD	MGI:1921453
Rattus norvegicus	EIF4ENIF1	RGD	RGD:1560908
Bos taurus	EIF4ENIF1	VGNC	VGNC:28414
Felis catus	EIF4ENIF1	VGNC	VGNC:61794
Canis familiaris	EIF4ENIF1	VGNC	VGNC:40288

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