HNRNPF - heterogeneous nuclear ribonucleoprotein F Gene

中文名称：异质核核糖核蛋白 F

种属: Homo sapiens

同用名: HNRPF; mcs94-1; OK/SW-cl.23

关于 HNRNPF

功能概要

该基因属于普遍表达的异质核核糖核蛋白 (hnRNP) 亚家族。 hnRNP 是与异质核 RNA (hnRNA) 复合的 RNA 结合蛋白。这些蛋白质与细胞核中的前体 mRNA 相关，并调节选择性剪接、聚腺苷酸化以及 mRNA 代谢和运输的其他方面。虽然所有的 hnRNP 都存在于细胞核中，但有些似乎在细胞核和细胞质之间穿梭。 hnRNP 蛋白具有独特的核酸结合特性。由该基因编码的蛋白质具有三个重复的准 RRM 结构域，这些结构域与具有富含鸟苷序列的 RNA 结合。这种蛋白质与家族成员 hnRPH 非常相似。已经鉴定出编码相同蛋白质的多个可变剪接变体。[RefSeq 提供，2008 年 7 月]

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and Other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRPH. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]