2. Gene
  3. TGM7 - transglutaminase 7 Gene

TGM7 - transglutaminase 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：转谷氨酰胺酶 7

种属: Homo sapiens

同用名: TGMZ

基因 ID: 116179 | 基因类型: protein coding

关于 TGM7

Cytogenetic location: 15q15.2-q15.3 Genomic coordinates (GRCh38): 15:43,276,271-43,302,255 (from NCBI)

This gene has 2 transcripts (splice variants), 121 orthologues and 8 paralogues. Low expression observed in reference dataset.

功能概要

转谷氨酰胺酶 (TGM; EC 2.3.2.13) 是结构和功能相关的酶家族，通过形成 γ-谷氨酰-ε 赖氨酸交联来稳定蛋白质组装。有关转谷氨酰胺酶的其他背景信息，请参阅 TGM1 (MIM 190195) 。[OMIM 提供，2002 年 7 月]

Transglutaminases (TGM; EC 2.3.2.13) are a family of structurally and functionally related Enzymes that stabilize protein assemblies through the formation of gamma-glutamyl-epsilon lysine crosslinks. For additional background information on transglutaminases, see TGM1 (MIM 190195).[supplied by OMIM, Jul 2002]

TGM7 基因产物(1)

mRNA Protein Name
NM_052955.3 NP_443187.1 protein-glutamine gamma-glutamyltransferase Z
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TGM7 蛋白结构

Transglut_N

Transglut_N: Transglutaminase family (7 - 124)

Transglut_core

Transglut_core: Transglutaminase-like superfamily (275 - 362)

Transglut_C

Transglut_C: Transglutaminase family, C-terminal ig like domain (608 - 705)

  • 0
  • 200
  • 400
  • 600
  • 710 a.a.
蛋白主名 其他名称

protein-glutamine gamma-glutamyltransferase Z

TG(Z)

TGM7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TGM7 Q96PF1 LAMTOR3 Homo sapiens Q9UHA4
Validated Y2H
32296183
Intra TGM7 Q96PF1 KRT39 Homo sapiens Q6A163
Y2H Prey Pooling
32296183
Intra TGM7 Q96PF1 KRT39 Homo sapiens Q6A163
Y2H Array
32296183
Intra TGM7 Q96PF1 UNKL Homo sapiens Q9H9P5-5
Validated Y2H
32296183
Intra TGM7 Q96PF1 UNKL Homo sapiens Q9H9P5-5
Y2H Array
32296183
Intra TGM7 Q96PF1 UNKL Homo sapiens Q9H9P5-5
Y2H Prey Pooling
32296183
Intra TGM7 Q96PF1 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Prey Pooling
32296183
Intra TGM7 Q96PF1 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Array
32296183
Intra TGM7 Q96PF1 SDS Homo sapiens P20132
Y2H Prey Pooling
32296183
Intra TGM7 Q96PF1 SDS Homo sapiens P20132
Y2H Array
32296183
Intra TGM7 Q96PF1 SPRY1 Homo sapiens O43609
Y2H Array
32296183
Intra TGM7 Q96PF1 SPRY1 Homo sapiens O43609
Y2H Prey Pooling
32296183
Intra TGM7 Q96PF1 TSSK3 Homo sapiens Q96PN8
Validated Y2H
32296183
Intra TGM7 Q96PF1 PPCDC Homo sapiens Q96CD2
Y2H Prey Pooling
32296183
Intra TGM7 Q96PF1 PPCDC Homo sapiens Q96CD2
Y2H Array
32296183
Intra TGM7 Q96PF1 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra TGM7 Q96PF1 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra TGM7 Q96PF1 KCTD1 Homo sapiens Q719H9
Y2H Array
32296183
Intra TGM7 Q96PF1 KCTD1 Homo sapiens Q719H9
Y2H Prey Pooling
32296183
Intra TGM7 Q96PF1 ARID5A Homo sapiens Q03989
Y2H Array
32296183
Intra TGM7 Q96PF1 ARID5A Homo sapiens Q03989
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Retinal Lattice Degeneration

Palisade Degeneration Of Retina

Lattice Retinal Degeneration
Richter'S Syndrome

Richter Syndrome

Richter Transformation
Gingival Fibromatosis

Hereditary Gingival Fibromatosis

Hereditary Gingival Hyperplasia

Autosomal Dominant Gingival Fibromatosis

Autosomal Dominant Gingival Hyperplasia

Fibromatosis, Gingival, Hereditary

Fibromatosis, Gingival
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14464 TGM7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TGM7 RGD RGD:7615199
Canis familiaris TGM7 VGNC VGNC:47320
Felis catus TGM7 VGNC VGNC:66145
Mus musculus TGM7 MGD MGI:2151164
Bos taurus TGM7 VGNC VGNC:35814
Macaca mulatta TGM7 VGNC VGNC:79880
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