PDLIM7 - PDZ and LIM domain 7 Gene

中文名称：PDZ 和 LIM 域 7

种属: Homo sapiens

同用名: LMP1; LMP3

基因 ID: 9260 | 基因类型: protein coding

关于 PDLIM7

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,483,394-177,497,604 (from NCBI)

This gene has 16 transcripts (splice variants), 198 orthologues and 7 paralogues. Broad expression in endometrium (RPKM 61.1), prostate (RPKM 52.9) and 22 other tissues.

功能概要

该基因编码的蛋白质代表了一个由保守的 PDZ 和 LIM 结构域组成的蛋白质家族。 LIM 结构域被提议在各种环境中的蛋白质-蛋白质识别中起作用，包括基因转录和发育以及细胞骨架相互作用。该蛋白的 LIM 结构域与蛋白激酶结合，而 PDZ 结构域与肌动蛋白丝结合。该基因产物参与肌动蛋白丝相关复合物的组装，该复合物对于 RET/ptc2 促有丝分裂信号的传递至关重要。生物学功能很可能是适配器的功能，PDZ 结构域将 LIM 结合蛋白定位到骨骼肌和非肌肉组织的肌动蛋白丝。该基因的可变剪接导致多个转录变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of RET/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

PDLIM7 基因产物(3)

mRNA	Protein	Name
NM_005451.5	NP_005442.2	PDZ and LIM domain protein 7 isoform 1
NM_203352.3	NP_976227.1	PDZ and LIM domain protein 7 isoform 2
NM_213636.3	NP_998801.1	PDZ and LIM domain protein 7 isoform 4

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in adherens junction	IDA IDA: 通过直接分析推断	25468996	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDLIM7 蛋白结构

PDZ

LIM

0
100
200
300
400
457 a.a.

蛋白主名

其他名称

PDZ and LIM domain protein 7

1110003B01Rik

PDLIM7 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	PDLIM7	Q9NR12	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	PDLIM7	Q9NR12	GPATCH2L	Homo sapiens	Q9NWQ4-1	Validated Y2H	32296183
Intra	PDLIM7	Q9NR12	TSG101	Homo sapiens	Q99816	Anti Tag CoIP	28514442
Intra	PDLIM7	Q9NR12	TSG101	Homo sapiens	Q99816	Y2H Prey Pooling	25416956
Intra	PDLIM7	Q9NR12	TSG101	Homo sapiens	Q99816	Y2H Array	25416956
Cross	PDLIM7	Q9NR12	Hoxa1	Mus musculus	P09022	Y2H	23088713
Cross	PDLIM7	Q9NR12	Hoxa1	Mus musculus	P09022	BiFC	23088713
Intra	PDLIM7	Q9NR12	PHF1	Homo sapiens	O43189	Y2H Array	31515488
Intra	PDLIM7	Q9NR12	UBQLN4	Homo sapiens	Q9NRR5	Y2H Array	16713569
Intra	PDLIM7	Q9NR12	HSPB7	Homo sapiens	Q9UBY9	Validated Y2H	32296183
Intra	PDLIM7	Q9NR12	TCF19	Homo sapiens	Q9Y242	Validated Y2H	32296183
Intra	PDLIM7	Q9NR12	WWP2	Homo sapiens	O00308	Validated Y2H	25416956
Intra	PDLIM7	Q9NR12	WWP2	Homo sapiens	O00308	Y2H Array	29892012
Intra	PDLIM7	Q9NR12	WWP2	Homo sapiens	O00308	Y2H Pooling	16189514
Intra	PDLIM7	Q9NR12	WWP2	Homo sapiens	O00308	Y2H Array	31515488
Intra	PDLIM7	Q9NR12	ENKD1	Homo sapiens	Q9H0I2	Y2H Pooling	16189514
Intra	PDLIM7	Q9NR12	GEM	Homo sapiens	P55040	Y2H Array	31515488
Intra	PDLIM7	Q9NR12	BAG3	Homo sapiens	O95817	Anti Tag CoIP	33961781
Intra	PDLIM7	Q9NR12	BAG3	Homo sapiens	O95817	Anti Tag CoIP	28514442
Intra	PDLIM7	Q9NR12	HEY2	Homo sapiens	Q9UBP5	Validated Y2H	32296183
Intra	PDLIM7	Q9NR12	IQGAP1	Homo sapiens	A4QPB0	Validated Y2H	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Endobronchial Leiomyoma

Larynx Squamous Papilloma

Laryngeal Squamous Cell Papilloma

Lymphoepithelioma-Like Carcinoma

Lymphoepithelial Carcinoma

Nasopharyngeal Type Undifferentiated Carcinoma

Lung Leiomyoma

Pulmonary Leiomyoma

Leiomyoma Of Lung

Pleural Empyema

Empyema	Pyothorax
Empyema, Pleural	Abscess Of Pleural Cavity
Abscess Of Thorax	Empyema Of Pleura
Empyema Of Pleura Without Fistula	Empyema With Fistula
Empyema With No Fistula	Empyema With Pleural Fistula
Empyema Without Mention Of Fistula	Empyema, Chest
Lung Empyema	Pleural Empyema With Fistula
Pleural Empyema With No Fistula	Purulent Pleurisy
Purulent Pleuritis	Thorax Abscess
Pyopneumothorax

Oral Hairy Leukoplakia

Hairy Leukoplakia	Leukoplakia, Hairy
Hairy Leucoplakia

Pfeiffer Syndrome

Infectious Mononucleosis	Acs5
Craniofacial-Skeletal-Dermatologic Dysplasia	Acs V
Noack Syndrome	Gammaherpesviral Mononucleosis
Acrocephalosyndactyly Type 5	Pfeiffer Syndrome Type 3
Acrocephalosyndactyly, Type V	Glandular Fever
Pfeiffer Type Acrocephalosyndactyly	Pfeiffer Syndrome Type 2
Acrocephalosyndactylia Type V	Filatov'S Disease
Monocytic Angina	Mononucleosis
Pfeiffer'S Disease	Acsv
Acrocephalosyndactyly, Type 5	Craniofacial-Skeletal-Dermatologic Syndrome
Pfeiffer Syndrome Type 1	Classic Pfeiffer Syndrome
PS	Pfeiffer Syndrome Variant
Dysplasia, Craniofacial-Skeletal-Dermatologic	Pfeiffer
Kissing Disease	Infectious Adenitis
Pfeiffer Disease

Mature B-Cell Neoplasm

Mature B-Cell Lymphocytic Neoplasm	Neoplasm Of Mature B-Cells
Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10284	PDLIM7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	PDLIM7	MGD	MGI:1914649
Bos taurus	PDLIM7	VGNC	VGNC:32712
Felis catus	PDLIM7	VGNC	VGNC:64093
Macaca mulatta	PDLIM7	VGNC	VGNC:75848
Rattus norvegicus	PDLIM7	RGD	RGD:628769

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