1. Gene
  2. AKIRIN2 - akirin 2 Gene

AKIRIN2 - akirin 2 Gene

中文名称:麒麟 2

种属: Homo sapiens

同用名: FBI1; C6orf166; dJ486L4.2

基因 ID: 55122 | 基因类型: protein coding

关于 AKIRIN2

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:87,674,860-87,702,233 (from NCBI)

This gene has 2 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 25.3), spleen (RPKM 21.1) and 24 other tissues.

功能概要

启用酶结合活性和相同的蛋白质结合活性。预计参与先天免疫反应的正调节和 RNA 聚合酶 II 转录的正调节。预计在白细胞介素 6 的产生和对脂多糖的反应的上游或内部发挥作用。位于核质中。 [由基因组资源联盟提供,2022 年 4 月]

Enables Enzyme binding activity and identical protein binding activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of interleukin-6 production and response to lipopolysaccharide. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

AKIRIN2 基因产物(1)

mRNA Protein Name
NM_018064.4 NP_060534.1 akirin-2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme binding IPI
IPI: 通过物理相互作用推断
23382074 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein-macromolecule adaptor activity IDA
IDA: 通过直接分析推断
34711951 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of positive effect nuclear protein quality control by the ubiquitin-proteasome system IDA
IDA: 通过直接分析推断
34711951 GOA
involved in proteasome localization IDA
IDA: 通过直接分析推断
34711951 GOA
involved in protein import into nucleus IDA
IDA: 通过直接分析推断
34711951 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in nucleus IDA
IDA: 通过直接分析推断
34711951 GOA
located in nucleus IDA
IDA: 通过直接分析推断
18066067 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

akirin-2

fourteen-three-three beta interactant 1

AKIRIN2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
AKIRIN2 Q53H80 MYOZ3 Homo sapiens Q8TDC0
Validated Y2H
32296183
种属内
AKIRIN2 Q53H80 MESD Homo sapiens Q14696
Y2H Prey Pooling
32296183
种属内
AKIRIN2 Q53H80 MESD Homo sapiens Q14696
Y2H Array
32296183
种属内
AKIRIN2 Q53H80 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
种属内
AKIRIN2 Q53H80 SORBS3 Homo sapiens O60504
Y2H Array
32296183
种属内
AKIRIN2 Q53H80 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
种属内
AKIRIN2 Q53H80 HSD17B14 Homo sapiens Q9BPX1
Y2H Prey Pooling
32296183
种属内
AKIRIN2 Q53H80 HSD17B14 Homo sapiens Q9BPX1
Validated Y2H
32296183
种属内
AKIRIN2 Q53H80 HSD17B14 Homo sapiens Q9BPX1
Y2H Array
32296183
种属内
AKIRIN2 Q53H80 SPG21 Homo sapiens Q9NZD8
Anti Tag CoIP
33961781
种属内
AKIRIN2 Q53H80 SPG21 Homo sapiens Q9NZD8
Anti Tag CoIP
28514442
种属内
AKIRIN2 Q53H80 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
种属内
AKIRIN2 Q53H80 SPG21 Homo sapiens Q9NZD8
Y2H Array
32296183
种属内
AKIRIN2 Q53H80 SPG21 Homo sapiens Q9NZD8
Y2H Prey Pooling
32296183
种属内
AKIRIN2 Q53H80 SPG21 Homo sapiens Q9NZD8
Y2H Array
31515488
种属内
AKIRIN2 Q53H80 AKIRIN2 Homo sapiens Q53H80
Validated Y2H
32296183
种属内
AKIRIN2 Q53H80 AKIRIN2 Homo sapiens Q53H80
Y2H Array
32296183
种属内
AKIRIN2 Q53H80 AKIRIN2 Homo sapiens Q53H80
Y2H Prey Pooling
32296183
种属内
AKIRIN2 Q53H80 RAN Homo sapiens P62826
Anti Tag CoIP
28514442
种属内
AKIRIN2 Q53H80 RAN Homo sapiens P62826
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Zebrafish Allergy

Danio Rerio Allergy

Tick Infestation

Tick Infestations

Metacarpal 4-5 Fusion

Syndactyly Type 8

MF4

Fusion Of Metacarpals 4 And 5

Metacarpals 4 And 5 Fusion

Metacarpal 4 5 Fusion

Parasitic Ectoparasitic Infectious Disease

Ectoparasitic Infestations

Ectoparasitism

Lice Infestation

Pediculosis

Louse Infestation

Mixed Pediculosis

Lice Infestations

Infestation By Pediculus

Mixed Pediculosis Infestation

Pediculosis + Lice

Pediculosis And Phthirus Infection

Pediculosis And Phthirus Infections

Pediculosis And Phthirus Infestation

Infestation By Anoplura

Pediculus Infestation

Lice Nos

Tick Paralysis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus AKIRIN2 VGNC VGNC:25794
Mus musculus AKIRIN2 MGD MGI:1889364
Canis familiaris AKIRIN2 VGNC VGNC:37766
Felis catus AKIRIN2 VGNC VGNC:59721
Rattus norvegicus AKIRIN2 RGD RGD:1307791
Macaca mulatta AKIRIN2 VGNC VGNC:69665