1. Gene
  2. SORBS3 - sorbin and SH3 domain containing 3 Gene

SORBS3 - sorbin and SH3 domain containing 3 Gene

中文名称:含山梨醇和 SH3 结构域

种属: Homo sapiens

同用名: SCAM1; SH3D4; SCAM-1

基因 ID: 10174 | 基因类型: protein coding

关于 SORBS3

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,544,973-22,575,788 (from NCBI)

This gene has 22 transcripts (splice variants), 206 orthologues and 12 paralogues. Ubiquitous expression in fat (RPKM 30.7), testis (RPKM 27.8) and 24 other tissues.

功能概要

该基因编码一个包含 SH3 结构域的衔接蛋白。 SH3 结构域的存在在这种蛋白质结合其他细胞质分子的能力中发挥作用,并有助于细胞骨架组织、细胞粘附和迁移、信号传导和基因表达。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供,2011 年 11 月]

This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

SORBS3 基因产物(2)

mRNA Protein Name
NM_001018003.3 NP_001018003.1 vinexin isoform 2
NM_005775.5 NP_005766.3 vinexin isoform 1

SORBS3 蛋白结构

Sorb

Sorb: Sorbin homologous domain (120 - 156)

SH3_9

SH3_9: Variant SH3 domain (388 - 435)

SH3_1

SH3_1: SH3 domain (460 - 507)

SH3_9

SH3_9: Variant SH3 domain (619 - 669)

  • 0
  • 200
  • 400
  • 600
  • 671 a.a.
蛋白主名 其他名称

vinexin

sorbin and SH3 domain-containing protein 3

SORBS3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SORBS3 O60504 CCDC102B Homo sapiens Q68D86
Validated Y2H
32296183
Intra SORBS3 O60504 PNMA5 Homo sapiens Q96PV4
Validated Y2H
32296183
Intra SORBS3 O60504 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
32296183
Intra SORBS3 O60504 HNRNPUL1 Homo sapiens Q9BUJ2
Validated Y2H
25416956
Intra SORBS3 O60504 HNRNPUL1 Homo sapiens Q9BUJ2
Y2H Array
25416956
Intra SORBS3 O60504 EIF3S3 Homo sapiens Q6IB98
Y2H Array
25416956
Intra SORBS3 O60504 IQUB Homo sapiens Q8NA54
Validated Y2H
32296183
Intra SORBS3 O60504 DIP2A Homo sapiens Q14689-6
Validated Y2H
25416956
Intra SORBS3 O60504 TSGA10IP Homo sapiens Q3SY00
Validated Y2H
32296183
Intra SORBS3 O60504 VARS2 Homo sapiens Q5ST30-4
Y2H Prey Pooling
25416956
Intra SORBS3 O60504 NFKBID Homo sapiens Q8NI38
Validated Y2H
32296183
Intra SORBS3 O60504 SH2D4A Homo sapiens Q9H788-2
Y2H Array
25416956
Intra SORBS3 O60504 SH2D4A Homo sapiens Q9H788-2
Validated Y2H
25416956
Intra SORBS3 O60504 SH2D4A Homo sapiens Q9H788-2
Y2H Prey Pooling
25416956
Intra SORBS3 O60504 CCDC6 Homo sapiens Q16204
Validated Y2H
32296183
Intra SORBS3 O60504 PAK2 Homo sapiens Q13177
Y2H
21516116
Intra SORBS3 O60504 PAK2 Homo sapiens Q13177
Phage Display
16374509
Intra SORBS3 O60504 GAS8 Homo sapiens O95995
Validated Y2H
32296183
Intra SORBS3 O60504 RAD51D Homo sapiens O75771
Validated Y2H
32296183
Intra SORBS3 O60504 CCDC57 Homo sapiens Q2TAC2-2
Validated Y2H
32296183
Intra SORBS3 O60504 VCL Homo sapiens P18206-2
Validated Y2H
32296183
Intra SORBS3 O60504 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra SORBS3 O60504 TEPSIN Homo sapiens Q96N21
Validated Y2H
32296183
Intra SORBS3 O60504 NEK6 Homo sapiens Q9HC98-4
Validated Y2H
32296183
Intra SORBS3 O60504 ANKS1A Homo sapiens Q49AR9
Validated Y2H
32296183
Intra SORBS3 O60504 TCEANC Homo sapiens Q8N8B7-2
Validated Y2H
32296183
Intra SORBS3 O60504 FBXL19 Homo sapiens Q6PCT2-2
Validated Y2H
32296183
Intra SORBS3 O60504 RUNX1T1 Homo sapiens Q06455-2
Validated Y2H
32296183
Intra SORBS3 O60504 PLEKHN1 Homo sapiens Q494U1-3
Validated Y2H
32296183
Intra SORBS3 O60504 GLRA1 Homo sapiens P23415
Validated Y2H
32296183
Intra SORBS3 O60504 INSC Homo sapiens Q1MX18
Validated Y2H
32296183
Intra SORBS3 O60504 SYNPO2L Homo sapiens Q9H987-2
Validated Y2H
32296183
Intra SORBS3 O60504 PPIL6 Homo sapiens Q8IXY8
Validated Y2H
32296183
Intra SORBS3 O60504 SETD5 Homo sapiens Q9C0A6-3
Validated Y2H
32296183
Intra SORBS3 O60504 ROPN1 Homo sapiens Q9HAT0
Validated Y2H
32296183
Intra SORBS3 O60504 PIBF1 Homo sapiens Q4G0R1
Validated Y2H
32296183
Intra SORBS3 O60504 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra SORBS3 O60504 MGC50722 Homo sapiens Q8IVT4
Validated Y2H
32296183
Intra SORBS3 O60504 ZC2HC1C Homo sapiens Q53FD0-2
Validated Y2H
32296183
Intra SORBS3 O60504 PHETA1 Homo sapiens Q8N4B1-4
Validated Y2H
32296183
Intra SORBS3 O60504 SOCS7 Homo sapiens O14512
IF
15242778
Intra SORBS3 O60504 SOCS7 Homo sapiens O14512
Anti Tag CoIP
15242778
Intra SORBS3 O60504 CPNE8 Homo sapiens Q86YQ8
Validated Y2H
32296183
Intra SORBS3 O60504 CPNE1 Homo sapiens Q99829
Validated Y2H
32296183
Intra SORBS3 O60504 FAM53C Homo sapiens Q9NYF3
Validated Y2H
32296183
Intra SORBS3 O60504 PPFIA3 Homo sapiens O75145
Validated Y2H
32296183
Intra SORBS3 O60504 VARS2 Homo sapiens Q5ST30
Validated Y2H
32296183
Intra SORBS3 O60504 MKRN3 Homo sapiens Q13064
Validated Y2H
32296183
Intra SORBS3 O60504 NAF1 Homo sapiens Q96HR8
Validated Y2H
32296183
Intra SORBS3 O60504 CHERP Homo sapiens Q8IWX8
Validated Y2H
32296183
Intra SORBS3 O60504 KANK2 Homo sapiens Q63ZY3
Validated Y2H
32296183
Intra SORBS3 O60504 PPP1R18 Homo sapiens Q6NYC8
Validated Y2H
32296183
Intra SORBS3 O60504 CCNL1 Homo sapiens Q9UK58
Validated Y2H
32296183
Intra SORBS3 O60504 WIPF2 Homo sapiens Q8TF74
Validated Y2H
32296183
Intra SORBS3 O60504 NHSL2 Homo sapiens Q5HYW2
Validated Y2H
32296183
Intra SORBS3 O60504 AKT2 Homo sapiens P31751
Validated Y2H
32296183
Intra SORBS3 O60504 HNRNPK Homo sapiens P61978
Validated Y2H
25416956
Intra SORBS3 O60504 HNRNPK Homo sapiens P61978
Y2H Array
25416956
Intra SORBS3 O60504 QARS1 Homo sapiens P47897
Validated Y2H
32296183
Intra SORBS3 O60504 DDX6 Homo sapiens P26196
Validated Y2H
32296183
Intra SORBS3 O60504 HNRNPF Homo sapiens P52597
Validated Y2H
32296183
Intra SORBS3 O60504 TXLNA Homo sapiens P40222
Validated Y2H
32296183
Intra SORBS3 O60504 RIN1 Homo sapiens Q13671
Validated Y2H
32296183
Intra SORBS3 O60504 COG4 Homo sapiens Q9H9E3
Validated Y2H
32296183
Intra SORBS3 O60504 ADAT3 Homo sapiens Q96EY9
Validated Y2H
32296183
Intra SORBS3 O60504 SAXO1 Homo sapiens Q8IYX7
Y2H Prey Pooling
25416956
Intra SORBS3 O60504 CDC23 Homo sapiens Q9UJX2
Validated Y2H
32296183
Intra SORBS3 O60504 VPS37B Homo sapiens Q9H9H4
Validated Y2H
25416956
Intra SORBS3 O60504 VPS37B Homo sapiens Q9H9H4
Y2H Prey Pooling
25416956
Intra SORBS3 O60504 RTKN Homo sapiens Q9BST9
Y2H
19294487
Intra SORBS3 O60504 HNRNPK Homo sapiens P61978-2
Validated Y2H
32296183
Intra SORBS3 O60504 CPNE2 Homo sapiens Q96FN4
Validated Y2H
25416956
Intra SORBS3 O60504 CPNE2 Homo sapiens Q96FN4
Validated Y2H
32296183
Intra SORBS3 O60504 CPNE2 Homo sapiens Q96FN4
Y2H Prey Pooling
25416956
Intra SORBS3 O60504 CDKN2C Homo sapiens P42773
Validated Y2H
32296183
Intra SORBS3 O60504 POLE2 Homo sapiens P56282
Validated Y2H
32296183
Intra SORBS3 O60504 POLE2 Homo sapiens P56282
Y2H Array
32296183
Intra SORBS3 O60504 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra SORBS3 O60504 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra SORBS3 O60504 TRIM41 Homo sapiens Q8WV44
Validated Y2H
25416956
Intra SORBS3 O60504 KIAA0408 Homo sapiens Q6ZU52
Validated Y2H
25416956
Intra SORBS3 O60504 KIAA0408 Homo sapiens Q6ZU52
Y2H Array
25416956
Intra SORBS3 O60504 CRACR2A Homo sapiens Q9BSW2
Validated Y2H
32296183
Intra SORBS3 O60504 DVL3 Homo sapiens Q92997
Validated Y2H
32296183
Intra SORBS3 O60504 TRIM23 Homo sapiens P36406
Validated Y2H
25416956
Intra SORBS3 O60504 TRIM23 Homo sapiens P36406
Validated Y2H
32296183
Intra SORBS3 O60504 TRIM23 Homo sapiens P36406
Y2H Array
25416956
Intra SORBS3 O60504 GYS1 Homo sapiens P13807
Validated Y2H
32296183
Intra SORBS3 O60504 CCNH Homo sapiens P51946
Validated Y2H
32296183
Intra SORBS3 O60504 PLOD3 Homo sapiens O60568
Validated Y2H
32296183
Intra SORBS3 O60504 PAK5 Homo sapiens Q9P286
Y2H Array
25416956
Intra SORBS3 O60504 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra SORBS3 O60504 AKIRIN2 Homo sapiens Q53H80
Validated Y2H
32296183
Intra SORBS3 O60504 EFHC1 Homo sapiens Q5JVL4
Validated Y2H
32296183
Intra SORBS3 O60504 USP2 Homo sapiens O75604
Validated Y2H
32296183
Intra SORBS3 O60504 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra SORBS3 O60504 GEM Homo sapiens P55040
Validated Y2H
32296183
Intra SORBS3 O60504 ZNF414 Homo sapiens Q96IQ9
Validated Y2H
32296183
Intra SORBS3 O60504 CATSPER1 Homo sapiens Q8NEC5
Validated Y2H
32296183
Intra SORBS3 O60504 CCDC120 Homo sapiens Q96HB5
Validated Y2H
32296183
Intra SORBS3 O60504 TSGA10 Homo sapiens Q9BZW7
Validated Y2H
32296183
Intra SORBS3 O60504 FNDC11 Homo sapiens Q9BVV2
Validated Y2H
32296183
Intra SORBS3 O60504 ATOSB Homo sapiens Q7L5A3
Validated Y2H
32296183
Intra SORBS3 O60504 GPKOW Homo sapiens Q92917
Validated Y2H
32296183
Intra SORBS3 O60504 SH2D4A Homo sapiens Q9H788
Y2H Prey Pooling
25416956
Intra SORBS3 O60504 SH2D4A Homo sapiens Q9H788
Validated Y2H
25416956
Intra SORBS3 O60504 SH2D4A Homo sapiens Q9H788
Validated Y2H
32296183
Intra SORBS3 O60504 SH2D4A Homo sapiens Q9H788
Y2H Array
25416956
Intra SORBS3 O60504 IMP3 Homo sapiens Q9NV31
Validated Y2H
32296183
Intra SORBS3 O60504 TEAD4 Homo sapiens Q15561
Validated Y2H
32296183
Intra SORBS3 O60504 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Intra SORBS3 O60504 CFAP206 Homo sapiens Q8IYR0
Validated Y2H
32296183
Intra SORBS3 O60504 NRBP1 Homo sapiens Q9UHY1
Validated Y2H
32296183
Intra SORBS3 O60504 GPANK1 Homo sapiens O95872
Validated Y2H
32296183
Intra SORBS3 O60504 NAB2 Homo sapiens Q15742
Validated Y2H
32296183
Intra SORBS3 O60504 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Intra SORBS3 O60504 TBC1D22B Homo sapiens Q9NU19
Validated Y2H
25416956
Intra SORBS3 O60504 TBC1D22B Homo sapiens Q9NU19
Y2H Array
29892012
Intra SORBS3 O60504 OSGIN1 Homo sapiens Q9UJX0
Validated Y2H
32296183
Intra SORBS3 O60504 TNS2 Homo sapiens Q63HR2
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spinocerebellar Ataxia, X-Linked 2

Scax2

X-Linked Spinocerebellar Ataxia 2

Cerebellar Ataxia With Extrapyramidal Involvement Early-Onset

Cerebellar Ataxia With Extrapyramidal Involvement, Early-Onset

Spinocerebellar Ataxia X-Linked Type 2

Cardiomyopathy, Dilated, 1p

Dilated Cardiomyopathy 1p

CMD1P

Cardiomyopathy, Dilated 1p

Cardiomyopathy, Dilated, Type 1p

Spinocerebellar Ataxia, Autosomal Recessive 3

SCAR3

Scabd

Autosomal Recessive Spinocerebellar Ataxia Type 3

Autosomal Recessive Spinocerebellar Ataxia-Blindness-Deafness Syndrome

Autosomal Recessive Spinocerebellar Ataxia-Blindness-Hearing Loss Syndrome

Spinocerebellar Ataxia With Blindness And Deafness

Autosomal Recessive Spinocerebellar Ataxia 3

Spinocerebellar Ataxia Autosomal Recessive 3

Autosomal Recessive Cerebellar Ataxia - Blindness - Deafness

Autosomal Recessive Cerebellar Ataxia-Blindness-Deafness Syndrome

Methemoglobinemia And Ambiguous Genitalia

METAG

Methemoglobinemia Type Iv

Isolated 17,20-Lyase Deficiency, Pure

Methemoglobinemia Due To Deficiency Of Cytochrome B5

Methemoglobinemia Type 4

Methemoglobinemia Type Iv, Formerly

Methemoglobinemia Due To Deficiency Of Cytochrome B5, Formerly

Pure Isolated 17,20-Lyase Deficiency

Methemoglobinemia, Type Iv

Schizophrenia 18

SCZD18

Schizophrenia 18 With Or Without An Affective Disorder

Schizophrenia Susceptibility 18

Chromosome 7q36.3 Duplication Syndrome, 362-Kb

Schizophrenia, Type 18

X-Linked Cerebellar Ataxia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus SORBS3 VGNC VGNC:65570
Canis familiaris SORBS3 VGNC VGNC:46658
Mus musculus SORBS3 MGD MGI:700013
Macaca mulatta SORBS3 VGNC VGNC:77803
Bos taurus SORBS3 VGNC VGNC:35129
Rattus norvegicus SORBS3 RGD RGD:628900