1. Gene
  2. CDC23 - cell division cycle 23 Gene

CDC23 - cell division cycle 23 Gene

中文名称:细胞分裂周期 23

种属: Homo sapiens

同用名: APC8; CUT23; ANAPC8

基因 ID: 8697 | 基因类型: protein coding

关于 CDC23

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,187,650-138,213,323 (from NCBI)

This gene has 9 transcripts (splice variants), 207 orthologues and 3 paralogues. Ubiquitous expression in placenta (RPKM 12.7), testis (RPKM 9.7) and 25 other tissues.

功能概要

由该基因编码的蛋白质与酿酒酵母 Cdc23 具有很强的相似性,Cdc23 是细胞周期通过 G2/M 转换所必需的蛋白质。该蛋白是后期促进复合物 (APC) 的组成部分,由八个蛋白质亚基组成,在真核细胞中高度保守。 APC 催化细胞周期蛋白 B-泛素偶联物的形成,后者负责泛素介导的 B 型细胞周期蛋白的蛋白水解。这种蛋白质和 APC 复合体的其他 3 个成员包含 TPR (四肽重复序列) ,这是一个对蛋白质-蛋白质相互作用很重要的蛋白质结构域。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 Other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]

CDC23 基因产物(1)

mRNA Protein Name
NM_004661.4 NP_004652.2 cell division cycle protein 23 homolog
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in anaphase-promoting complex-dependent catabolic process IDA
IDA: 通过直接分析推断
29033132 GOA
involved in mitotic cell cycle IDA
IDA: 通过直接分析推断
14657031 GOA
involved in mitotic metaphase chromosome alignment IDA
IDA: 通过直接分析推断
14657031 GOA
involved in protein K11-linked ubiquitination IDA
IDA: 通过直接分析推断
18485873 GOA
involved in protein K48-linked ubiquitination IDA
IDA: 通过直接分析推断
29033132 GOA
involved in protein branched polyubiquitination IDA
IDA: 通过直接分析推断
29033132 GOA
involved in regulation of mitotic metaphase/anaphase transition IDA
IDA: 通过直接分析推断
9790767 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of anaphase-promoting complex IDA
IDA: 通过直接分析推断
14657031 GOA
part of anaphase-promoting complex IPI
IPI: 通过物理相互作用推断
27120157 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CDC23 蛋白结构

ANAPC8

ANAPC8: Anaphase promoting complex subunit 8 / Cdc23 (28 - 151)

TPR_1

TPR_1: Tetratricopeptide repeat (332 - 364)

TPR_11

TPR_11: TPR repeat (367 - 430)

TPR_1

TPR_1: Tetratricopeptide repeat (438 - 459)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 597 a.a.
蛋白主名 其他名称

cell division cycle protein 23 homolog

anaphase-promoting complex subunit 8

CDC23 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CDC23 Q9UJX2 FLJ34048 Homo sapiens A4D1I3 25416956
种属内
CDC23 Q9UJX2 FAM9B Homo sapiens Q8IZU0 25416956
种属内
CDC23 Q9UJX2 FAM9B Homo sapiens Q8IZU0 25416956
种属内
CDC23 Q9UJX2 PIH1D2 Homo sapiens Q8WWB5 32296183
种属内
CDC23 Q9UJX2 PIH1D2 Homo sapiens Q8WWB5 32296183
种属内
CDC23 Q9UJX2 INPP5J Homo sapiens Q15735 25416956
种属内
CDC23 Q9UJX2 RBM15B Homo sapiens Q8NDT2-2 25416956
种属内
CDC23 Q9UJX2 SLC52A2 Homo sapiens Q9HAB3 25416956
种属内
CDC23 Q9UJX2 ANAPC13 Homo sapiens A8K3Z6 25416956
种属内
CDC23 Q9UJX2 JPH3 Homo sapiens Q8WXH2 32814053
种属内
CDC23 Q9UJX2 JPH3 Homo sapiens Q8WXH2 32814053
种属内
CDC23 Q9UJX2 JPH3 Homo sapiens Q8WXH2 32814053
种属内
CDC23 Q9UJX2 FSBP Homo sapiens O95073 25416956
种属内
CDC23 Q9UJX2 FSBP Homo sapiens O95073 25416956
种属内
CDC23 Q9UJX2 KIF1B Homo sapiens O60333-2 32814053
种属内
CDC23 Q9UJX2 KIF1B Homo sapiens O60333-2 32814053
种属内
CDC23 Q9UJX2 KIF1B Homo sapiens O60333-2 32814053
种属内
CDC23 Q9UJX2 DMWD Homo sapiens G5E9A7 32814053
种属内
CDC23 Q9UJX2 DMWD Homo sapiens G5E9A7 32814053
种属内
CDC23 Q9UJX2 DMWD Homo sapiens G5E9A7 32814053
种属内
CDC23 Q9UJX2 BAG6 Homo sapiens P46379-2 32814053
种属内
CDC23 Q9UJX2 BAG6 Homo sapiens P46379-2 32814053
种属内
CDC23 Q9UJX2 BAG6 Homo sapiens P46379-2 32814053
种属内
CDC23 Q9UJX2 CCDC24 Homo sapiens Q8N4L8 25416956
种属内
CDC23 Q9UJX2 CCDC24 Homo sapiens Q8N4L8 25416956
种属内
CDC23 Q9UJX2 TEPSIN Homo sapiens Q96N21 32296183
种属内
CDC23 Q9UJX2 TEPSIN Homo sapiens Q96N21 32296183
种属内
CDC23 Q9UJX2 FOXN1 Homo sapiens O15353 32296183
种属内
CDC23 Q9UJX2 FOXN1 Homo sapiens O15353 32296183
种属内
CDC23 Q9UJX2 PROSER3 Homo sapiens Q2NL68 32296183
种属内
CDC23 Q9UJX2 PROSER3 Homo sapiens Q2NL68 32296183
种属内
CDC23 Q9UJX2 GPRASP3 Homo sapiens Q6PI77 32296183
种属内
CDC23 Q9UJX2 GPRASP3 Homo sapiens Q6PI77 32296183
种属内
CDC23 Q9UJX2 CRTC2 Homo sapiens Q53ET0 32296183
种属内
CDC23 Q9UJX2 CRTC2 Homo sapiens Q53ET0 32296183
种属内
CDC23 Q9UJX2 STX2 Homo sapiens P32856-2 32296183
种属内
CDC23 Q9UJX2 STX2 Homo sapiens P32856-2 32296183
种属内
CDC23 Q9UJX2 KRT36 Homo sapiens O76013-2 32296183
种属内
CDC23 Q9UJX2 KRT36 Homo sapiens O76013-2 32296183
种属内
CDC23 Q9UJX2 SPAG8 Homo sapiens Q99932-2 32296183
种属内
CDC23 Q9UJX2 SPAG8 Homo sapiens Q99932-2 32296183
种属内
CDC23 Q9UJX2 USP54 Homo sapiens Q70EL1-9 32296183
种属内
CDC23 Q9UJX2 USP54 Homo sapiens Q70EL1-9 32296183
种属内
CDC23 Q9UJX2 CCDC125 Homo sapiens Q86Z20 32296183
种属内
CDC23 Q9UJX2 CCDC125 Homo sapiens Q86Z20 32296183
种属内
CDC23 Q9UJX2 DISC1 Homo sapiens Q9NRI5-2 32296183
种属内
CDC23 Q9UJX2 DISC1 Homo sapiens Q9NRI5-2 32296183
种属内
CDC23 Q9UJX2 POU6F2 Homo sapiens P78424 32296183
种属内
CDC23 Q9UJX2 POU6F2 Homo sapiens P78424 32296183
种属内
CDC23 Q9UJX2 LHX3 Homo sapiens Q9UBR4-2 32296183
种属内
CDC23 Q9UJX2 LHX3 Homo sapiens Q9UBR4-2 32296183
种属内
CDC23 Q9UJX2 LZTS1 Homo sapiens Q9Y250 32296183
种属内
CDC23 Q9UJX2 LZTS1 Homo sapiens Q9Y250 32296183
种属内
CDC23 Q9UJX2 LZTS1 Homo sapiens Q9Y250 32296183
种属内
CDC23 Q9UJX2 APOL1 Homo sapiens O14791 25416956
种属内
CDC23 Q9UJX2 CERCAM Homo sapiens Q5T4B2 32296183
种属内
CDC23 Q9UJX2 CERCAM Homo sapiens Q5T4B2 32296183
种属内
CDC23 Q9UJX2 DNAJB6 Homo sapiens O75190-2 32814053
种属内
CDC23 Q9UJX2 DNAJB6 Homo sapiens O75190-2 32814053
种属内
CDC23 Q9UJX2 DNAJB6 Homo sapiens O75190-2 32814053
种属内
CDC23 Q9UJX2 RBP3 Homo sapiens P10745 32296183
种属内
CDC23 Q9UJX2 RBP3 Homo sapiens P10745 32296183
种属内
CDC23 Q9UJX2 EURL Homo sapiens Q9NYK6-3 32296183
种属内
CDC23 Q9UJX2 EURL Homo sapiens Q9NYK6-3 32296183
种属内
CDC23 Q9UJX2 ANKRD11 Homo sapiens X5D778 32296183
种属内
CDC23 Q9UJX2 ANKRD11 Homo sapiens X5D778 32296183
种属内
CDC23 Q9UJX2 ANKRD11 Homo sapiens X5D778 32296183
种属内
CDC23 Q9UJX2 LAMP2 Homo sapiens P13473-2 32814053
种属内
CDC23 Q9UJX2 LAMP2 Homo sapiens P13473-2 32814053
种属内
CDC23 Q9UJX2 LAMP2 Homo sapiens P13473-2 32814053
种属内
CDC23 Q9UJX2 SSX2IP Homo sapiens Q9Y2D8 25416956
种属内
CDC23 Q9UJX2 SSX2IP Homo sapiens Q9Y2D8 25416956
种属内
CDC23 Q9UJX2 SSX2IP Homo sapiens Q9Y2D8 25416956
种属内
CDC23 Q9UJX2 NRBF2 Homo sapiens Q96F24 32296183
种属内
CDC23 Q9UJX2 NRBF2 Homo sapiens Q96F24 32296183
种属内
CDC23 Q9UJX2 KCTD6 Homo sapiens Q8NC69 32296183
种属内
CDC23 Q9UJX2 KCTD6 Homo sapiens Q8NC69 25416956
种属内
CDC23 Q9UJX2 KCTD6 Homo sapiens Q8NC69 32296183
种属内
CDC23 Q9UJX2 ANAPC13 Homo sapiens Q9BS18 32296183
种属内
CDC23 Q9UJX2 ANAPC13 Homo sapiens Q9BS18
TAP
20360068
种属内
CDC23 Q9UJX2 ANAPC13 Homo sapiens Q9BS18 35271311
种属内
CDC23 Q9UJX2 ANAPC13 Homo sapiens Q9BS18 32296183
种属内
CDC23 Q9UJX2 ANAPC13 Homo sapiens Q9BS18 26496610
种属内
CDC23 Q9UJX2 TOR1A Homo sapiens O14656-2 32814053
种属内
CDC23 Q9UJX2 TOR1A Homo sapiens O14656-2 32814053
种属内
CDC23 Q9UJX2 TOR1A Homo sapiens O14656-2 32814053
种属内
CDC23 Q9UJX2 TNIP1 Homo sapiens Q15025 32296183
种属内
CDC23 Q9UJX2 TNIP1 Homo sapiens Q15025 32296183
种属内
CDC23 Q9UJX2 BYSL Homo sapiens Q13895 25416956
种属内
CDC23 Q9UJX2 BYSL Homo sapiens Q13895 25416956
种属内
CDC23 Q9UJX2 RAC1 Homo sapiens P63000 25416956
种属内
CDC23 Q9UJX2 RAC1 Homo sapiens P63000 25416956
种属内
CDC23 Q9UJX2 SPRED1 Homo sapiens Q7Z699 32814053
种属内
CDC23 Q9UJX2 SPRED1 Homo sapiens Q7Z699 32814053
种属内
CDC23 Q9UJX2 SPRED1 Homo sapiens Q7Z699 32814053
种属内
CDC23 Q9UJX2 PRPF40A Homo sapiens O75400-2 32814053
种属内
CDC23 Q9UJX2 PRPF40A Homo sapiens O75400-2 32814053
种属内
CDC23 Q9UJX2 PRPF40A Homo sapiens O75400-2 32814053
种属内
CDC23 Q9UJX2 BCAS3 Homo sapiens Q9H6U6 25416956
种属内
CDC23 Q9UJX2 INCA1 Homo sapiens Q0VD86 25416956
种属内
CDC23 Q9UJX2 INCA1 Homo sapiens Q0VD86 25416956
种属内
CDC23 Q9UJX2 ATXN10 Homo sapiens Q9UBB4 32814053
种属内
CDC23 Q9UJX2 ATXN10 Homo sapiens Q9UBB4 32814053
种属内
CDC23 Q9UJX2 ATXN10 Homo sapiens Q9UBB4 32814053
种属内
CDC23 Q9UJX2 MAGED1 Homo sapiens Q9Y5V3 32296183
种属内
CDC23 Q9UJX2 MAGED1 Homo sapiens Q9Y5V3 32296183
种属内
CDC23 Q9UJX2 MAGED1 Homo sapiens Q9Y5V3 32296183
种属内
CDC23 Q9UJX2 CASP6 Homo sapiens P55212 32814053
种属内
CDC23 Q9UJX2 CASP6 Homo sapiens P55212 32814053
种属内
CDC23 Q9UJX2 CASP6 Homo sapiens P55212 32814053
种属内
CDC23 Q9UJX2 TRIM27 Homo sapiens P14373 25416956
种属内
CDC23 Q9UJX2 TRIM27 Homo sapiens P14373 25416956
种属内
CDC23 Q9UJX2 TRIM27 Homo sapiens P14373
Y2H
21516116
种属内
CDC23 Q9UJX2 PHYH Homo sapiens O14832 32814053
种属内
CDC23 Q9UJX2 PHYH Homo sapiens O14832 32814053
种属内
CDC23 Q9UJX2 PHYH Homo sapiens O14832 32814053
种属内
CDC23 Q9UJX2 GORASP2 Homo sapiens Q9H8Y8 32296183
种属内
CDC23 Q9UJX2 GORASP2 Homo sapiens Q9H8Y8 25416956
种属内
CDC23 Q9UJX2 GORASP2 Homo sapiens Q9H8Y8 32296183
种属内
CDC23 Q9UJX2 GORASP2 Homo sapiens Q9H8Y8 25416956
种属内
CDC23 Q9UJX2 TSC22D4 Homo sapiens Q9Y3Q8 32296183
种属内
CDC23 Q9UJX2 TSC22D4 Homo sapiens Q9Y3Q8 16189514
种属内
CDC23 Q9UJX2 TSC22D4 Homo sapiens Q9Y3Q8 32296183
种属内
CDC23 Q9UJX2 TSC22D4 Homo sapiens Q9Y3Q8 32296183
种属内
CDC23 Q9UJX2 CRACR2A Homo sapiens Q9BSW2 25416956
种属内
CDC23 Q9UJX2 CRACR2A Homo sapiens Q9BSW2 25416956
种属内
CDC23 Q9UJX2 CRACR2A Homo sapiens Q9BSW2 25416956
种属内
CDC23 Q9UJX2 RBPMS Homo sapiens Q93062 25416956
种属内
CDC23 Q9UJX2 RBPMS Homo sapiens Q93062 25416956
种属内
CDC23 Q9UJX2 RBPMS Homo sapiens Q93062 16189514
种属内
CDC23 Q9UJX2 LZTS2 Homo sapiens Q9BRK4 25416956
种属内
CDC23 Q9UJX2 LZTS2 Homo sapiens Q9BRK4 25416956
种属内
CDC23 Q9UJX2 NUP54 Homo sapiens Q7Z3B4 32296183
种属内
CDC23 Q9UJX2 NUP54 Homo sapiens Q7Z3B4 32296183
种属内
CDC23 Q9UJX2 SORBS3 Homo sapiens O60504 32296183
种属内
CDC23 Q9UJX2 SORBS3 Homo sapiens O60504 32296183
种属内
CDC23 Q9UJX2 CBY2 Homo sapiens Q8NA61 25416956
种属内
CDC23 Q9UJX2 CBY2 Homo sapiens Q8NA61 25416956
种属内
CDC23 Q9UJX2 BEGAIN Homo sapiens Q9BUH8 32296183
种属内
CDC23 Q9UJX2 BEGAIN Homo sapiens Q9BUH8 32296183
种属内
CDC23 Q9UJX2 CEP44 Homo sapiens Q9C0F1 25416956
种属内
CDC23 Q9UJX2 GFAP Homo sapiens P14136 32814053
种属内
CDC23 Q9UJX2 GFAP Homo sapiens P14136 32814053
种属内
CDC23 Q9UJX2 GFAP Homo sapiens P14136 32814053
种属内
CDC23 Q9UJX2 CYB5R2 Homo sapiens Q6BCY4 25416956
种属内
CDC23 Q9UJX2 CYB5R2 Homo sapiens Q6BCY4 25416956
种属内
CDC23 Q9UJX2 SIAH1 Homo sapiens Q8IUQ4 25416956
种属内
CDC23 Q9UJX2 ATRIP Homo sapiens Q8WXE1 25416956
种属内
CDC23 Q9UJX2 ATRIP Homo sapiens Q8WXE1 25416956
种属内
CDC23 Q9UJX2 EIF5A2 Homo sapiens Q9GZV4 25416956
种属内
CDC23 Q9UJX2 EIF5A2 Homo sapiens Q9GZV4 25416956
种属内
CDC23 Q9UJX2 OPTN Homo sapiens Q96CV9 25416956
种属内
CDC23 Q9UJX2 OPTN Homo sapiens Q96CV9 25416956
种属内
CDC23 Q9UJX2 PRPS1 Homo sapiens P60891 32814053
种属内
CDC23 Q9UJX2 PRPS1 Homo sapiens P60891 32814053
种属内
CDC23 Q9UJX2 PRPS1 Homo sapiens P60891 32814053
种属内
CDC23 Q9UJX2 RSL24D1 Homo sapiens Q9UHA3 25416956
种属内
CDC23 Q9UJX2 RSL24D1 Homo sapiens Q9UHA3 25416956
种属内
CDC23 Q9UJX2 PFKFB4 Homo sapiens Q16877 32296183
种属内
CDC23 Q9UJX2 PFKFB4 Homo sapiens Q16877 32296183
种属内
CDC23 Q9UJX2 INO80E Homo sapiens Q8NBZ0 32296183
种属内
CDC23 Q9UJX2 INO80E Homo sapiens Q8NBZ0 32296183
种属内
CDC23 Q9UJX2 IHO1 Homo sapiens Q8IYA8 25416956
种属内
CDC23 Q9UJX2 IHO1 Homo sapiens Q8IYA8 32296183
种属内
CDC23 Q9UJX2 IHO1 Homo sapiens Q8IYA8 32296183
种属内
CDC23 Q9UJX2 NAB2 Homo sapiens Q15742 32296183
种属内
CDC23 Q9UJX2 NAB2 Homo sapiens Q15742 32296183
种属内
CDC23 Q9UJX2 COIL Homo sapiens P38432 25416956
种属内
CDC23 Q9UJX2 COIL Homo sapiens P38432 25416956
种属内
CDC23 Q9UJX2 COIL Homo sapiens P38432 25416956
种属内
CDC23 Q9UJX2 KLF11 Homo sapiens O14901 32814053
种属内
CDC23 Q9UJX2 KLF11 Homo sapiens O14901 32814053
种属内
CDC23 Q9UJX2 KLF11 Homo sapiens O14901 32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Neurotic Excoriation

Factitious Skin Disease

Dermatitis Artefacta

Dermatitis Factitia

Dermatitis Ficta

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CDC23 RGD RGD:1304819
Mus musculus CDC23 MGD MGI:1098815
Felis catus CDC23 VGNC VGNC:82463
Bos taurus CDC23 VGNC VGNC:50038
Macaca mulatta CDC23 VGNC VGNC:70793
Canis familiaris CDC23 VGNC VGNC:51703