BCAS3 - BCAS3 microtubule associated cell migration factor Gene

中文名称：BCAS3 微管相关细胞迁移因子

种属: Homo sapiens

同用名: MAAB; GAOB1; PHAF2; HEMARS

基因 ID: 54828 | 基因类型: protein coding

关于 BCAS3

Cytogenetic location: 17q23.2 Genomic coordinates (GRCh38): 17:60,677,851-61,392,831 (from NCBI)

This gene has 34 transcripts (splice variants), 212 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 4.9), brain (RPKM 4.0) and 25 other tissues.

功能概要

启用多种功能，包括乙酰转移酶激活剂活性； β-微管蛋白结合活性；和组蛋白乙酰转移酶结合活性。参与细胞对雌激素刺激的反应；催化活性的正调节；和 RNA 聚合酶 II 对转录的正调控。位于细胞核；吞噬细胞组装位点；和转录活性染色质。乳腺癌的生物标志物。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including acetyltransferase activator activity; beta-tubulin binding activity; and Histone Acetyltransferase binding activity. Involved in cellular response to estrogen stimulus; positive regulation of catalytic activity; and positive regulation of transcription by RNA polymerase II. Located in nucleus; phagophore assembly site; and transcriptionally active chromatin. Biomarker of breast Cancer. [provided by Alliance of Genome Resources, Apr 2022]

BCAS3 基因产物(8)

mRNA	Protein	Name
NM_001099432.3	NP_001092902.1	BCAS3 microtubule associated cell migration factor isoform 1
NM_001320470.3	NP_001307399.1	BCAS3 microtubule associated cell migration factor isoform 3
NM_001330413.2	NP_001317342.1	BCAS3 microtubule associated cell migration factor isoform 4
NM_001330414.2	NP_001317343.1	BCAS3 microtubule associated cell migration factor isoform 5
NM_001353144.2	NP_001340073.1	BCAS3 microtubule associated cell migration factor isoform 6
NM_001353145.2	NP_001340074.1	BCAS3 microtubule associated cell migration factor isoform 7
NM_001353146.2	NP_001340075.1	BCAS3 microtubule associated cell migration factor isoform 8
NM_017679.5	NP_060149.3	BCAS3 microtubule associated cell migration factor isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables acetyltransferase activator activity	IDA IDA: 通过直接分析推断	17505058	GOA
enables beta-tubulin binding	IDA IDA: 通过直接分析推断	22300583	GOA
enables chromatin binding	IDA IDA: 通过直接分析推断	17505058	GOA
enables histone acetyltransferase binding	IPI IPI: 通过物理相互作用推断	17505058	GOA
enables histone binding	IDA IDA: 通过直接分析推断	17505058	GOA
enables nuclear receptor binding	IPI IPI: 通过物理相互作用推断	17505058	GOA
enables phosphatidylinositol binding	IDA IDA: 通过直接分析推断	33499712	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17505058	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to estrogen stimulus	IDA IDA: 通过直接分析推断	17505058	GOA
involved in positive regulation of catalytic activity	IDA IDA: 通过直接分析推断	17505058	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	17505058	GOA
involved in response to estrogen	IDA IDA: 通过直接分析推断	16617102	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	16617102	GOA
located in euchromatin	IDA IDA: 通过直接分析推断	17505058	GOA
located in nucleus	IDA IDA: 通过直接分析推断	16617102	GOA
located in phagophore assembly site	IDA IDA: 通过直接分析推断	33499712	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BCAS3 蛋白结构

WD40

BCAS3

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200
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800
928 a.a.

蛋白主名

其他名称

BCAS3 microtubule associated cell migration factor

BCAS4/BCAS3 fusion

BCAS3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	BCAS3	Q9H6U6	CTBP1	Homo sapiens	Q13363-2	Y2H Array	25416956
种属内	BCAS3	Q9H6U6	CTBP2	Homo sapiens	P56545-3	Validated Y2H	25416956
种属内	BCAS3	Q9H6U6	CTBP2	Homo sapiens	P56545-3	Y2H Array	25416956
种属内	BCAS3	Q9H6U6	VIM	Homo sapiens	P08670	Confocal	22300583
种属内	BCAS3	Q9H6U6	CDC23	Homo sapiens	Q9UJX2	Y2H Prey Pooling	25416956
种属内	BCAS3	Q9H6U6	CDC23	Homo sapiens	Q9UJX2	Y2H Array	25416956
种属内	BCAS3	Q9H6U6	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
种属内	BCAS3	Q9H6U6	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
种属内	BCAS3	Q9H6U6	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
种属内	BCAS3	Q9H6U6	PHAF1	Homo sapiens	Q9BSU1	Y2H Array	31515488

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hengel-Maroofian-Schols Syndrome

HEMARS

Neurodevelopmental Disorder With Spasticity, Facial Dysmorphism, And Brain Abnormalities

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01401	BCAS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	BCAS3	MGD	MGI:2385848
Bos taurus	BCAS3	VGNC	VGNC:26438
Macaca mulatta	BCAS3	VGNC	VGNC:70073
Felis catus	BCAS3	VGNC	VGNC:60080
Rattus norvegicus	BCAS3	RGD	RGD:1560788
Canis familiaris	BCAS3	VGNC	VGNC:38400

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

BCAS3 - BCAS3 microtubule associated cell migration factor Gene

关于 BCAS3

功能概要

BCAS3 基因产物(8)

BCAS3 蛋白结构

BCAS3 蛋白互作信息

关联疾病

直系同源

热门区域

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BCAS3 - BCAS3 microtubule associated cell migration factor Gene

关于 BCAS3

功能概要

BCAS3 基因产物(8)

BCAS3 蛋白结构

BCAS3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z