RSL24D1 - ribosomal L24 domain containing 1 Gene

中文名称：含核糖体 L24 域 1

种属: Homo sapiens

同用名: L30; RLP24; RPL24; TVAS3; RPL24L; C15orf15; HRP-L30-iso

基因 ID: 51187 | 基因类型: protein coding

关于 RSL24D1

Cytogenetic location: 15q21.3 Genomic coordinates (GRCh38): 15:55,180,806-55,196,941 (from NCBI)

This gene has 12 transcripts (splice variants), 206 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 88.8), ovary (RPKM 69.7) and 25 other tissues.

功能概要

该基因编码的蛋白质与人类核糖体蛋白 L24 具有低水平的序列相似性。尽管该基因在序列数据库中被称为 RPL24、L30 和 60S 核糖体蛋白 L30 同源基因，但它不同于正式命名为 RPL24 (其本身被称为核糖体蛋白 L30) 和 RPL30 的人类基因。由该基因编码的蛋白质定位于核仁，被认为在 60S 核糖体亚基的生物合成中发挥作用。该基因的确切功能目前尚不清楚。该基因利用替代性聚腺苷酸化信号并具有多个假基因。[RefSeq 提供，2012 年 7 月]

This gene encodes a protein sharing a low level of sequence similarity with human ribosomal protein L24. Although this gene has been referred to as RPL24, L30, and 60S ribosomal protein L30 isolog in the sequence databases, it is distinct from the human genes officially named RPL24 (which itself has been referred to as ribosomal protein L30) and RPL30. The protein encoded by this gene localizes to the nucleolus and is thought to play a role in the biogenesis of the 60S ribosomal subunit. The precise function of this gene is currently unknown. This gene utilizes alternative polyadenylation signals and has multiple pseudogenes. [provided by RefSeq, Jul 2012]

RSL24D1 基因产物(1)

mRNA	Protein	Name
NM_016304.3	NP_057388.1	probable ribosome biogenesis protein RLP24

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RSL24D1 蛋白结构

Ribosomal_L24e

0
100
163 a.a.

蛋白主名

其他名称

probable ribosome biogenesis protein RLP24

60S ribosomal protein L30 isolog

RSL24D1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	RSL24D1	Q9UHA3	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
Intra	RSL24D1	Q9UHA3	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
Intra	RSL24D1	Q9UHA3	CDC23	Homo sapiens	Q9UJX2	Validated Y2H	25416956
Intra	RSL24D1	Q9UHA3	DNMT3L	Homo sapiens	Q9UJW3	Y2H Array	32296183
Intra	RSL24D1	Q9UHA3	DNMT3L	Homo sapiens	Q9UJW3	Validated Y2H	32296183
Intra	RSL24D1	Q9UHA3	DNMT3L	Homo sapiens	Q9UJW3	Y2H Prey Pooling	25416956
Intra	RSL24D1	Q9UHA3	DNMT3L	Homo sapiens	Q9UJW3	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Shwachman-Diamond Syndrome 1

Shwachman-Diamond Syndrome	Shwachman Syndrome
Shwachman-Bodian-Diamond Syndrome	Sds
Pancreatic Insufficiency And Bone Marrow Dysfunction	Shwachman-Bodian Syndrome
SDS1	Lipomatosis Of Pancreas, Congenital
Congenital Lipomatosis Of Pancreas	Shwachman-Diamond Type Metaphyseal Dysplasia
Metaphyseal Chondrodysplasia, Shwachman Type	Shwachman-Diamond-Oski Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12301	RSL24D1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	RSL24D1	RGD	RGD:1309784
Canis familiaris	RSL24D1	VGNC	VGNC:45776
Bos taurus	RSL24D1	VGNC	VGNC:34181
Mus musculus	RSL24D1	MGD	MGI:2681840
Macaca mulatta	RSL24D1	VGNC	VGNC:99234
Felis catus	RSL24D1	VGNC	VGNC:104715

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