BYSL - bystin like Gene

中文名称：样

种属: Homo sapiens

同用名: Enp1; BYSTIN

关于 BYSL

功能概要

Bystin 在 SNG-M 细胞和人类滋养层畸胎瘤 HT-H 细胞中以 2-kb 的主要转录物和 3.6-kb 的次要转录物的形式表达。蛋白质结合测定确定 bystin 直接与 trophinin 和 tastin 结合，并且当细胞角蛋白 8 和 18 存在时，结合会增强。 HT-H 细胞的免疫细胞化学显示 bystin 与 trophinin、tastin 和细胞角蛋白共定位，表明这些分子在植入时在滋养外胚层细胞中形成复合物。使用免疫组织化学确定，从怀孕第六周起，在胎盘中发现了 trophinin 和 bystin。这两种蛋白质都位于绒毛膜绒毛合体滋养细胞的细胞质和子宫胎盘界面的子宫内膜蜕膜细胞中。第 10 周后，胎盘绒毛中的 trophinin、tastin 和 bystin 水平下降，然后消失。[RefSeq 提供，2008 年 7 月]

Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi. [provided by RefSeq, Jul 2008]