RACGAP1 - Rac GTPase activating protein 1 Gene

中文名称：Rac GTPase 激活蛋白 1

种属: Homo sapiens

同用名: CYK4; CDAN3B; ID-GAP; HsCYK-4; MgcRacGAP

基因 ID: 29127 | 基因类型: protein coding

关于 RACGAP1

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,989,162-50,033,440 (from NCBI)

This gene has 28 transcripts (splice variants) and 269 orthologues. Broad expression in testis (RPKM 17.3), bone marrow (RPKM 8.3) and 20 other tissues.

功能概要

该基因编码一种 GTP 酶激活蛋白 (GAP) ，它是中心纺锤体复合物的一个组成部分。这种蛋白质结合 Rho GTP 酶的活化形式并刺激 GTP 水解，从而导致 Rho 介导的信号的负调节。这种蛋白质在胞质分裂、细胞生长和分化中起调节作用。已发现该基因的可变剪接转录物变体。该基因在 12 号染色体上有一个假基因。[RefSeq 提供，2016 年 2 月]

This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. [provided by RefSeq, Feb 2016]

RACGAP1 基因产物(12)

mRNA	Protein	Name
NM_001126103.3	NP_001119575.1	rac GTPase-activating protein 1 isoform a
NM_001126104.3	NP_001119576.1	rac GTPase-activating protein 1 isoform a
NM_001319999.2	NP_001306928.1	rac GTPase-activating protein 1 isoform a
NM_001320000.2	NP_001306929.1	rac GTPase-activating protein 1 isoform a
NM_001320001.2	NP_001306930.1	rac GTPase-activating protein 1 isoform a
NM_001320002.2	NP_001306931.1	rac GTPase-activating protein 1 isoform a
NM_001320003.2	NP_001306932.1	rac GTPase-activating protein 1 isoform a
NM_001320004.2	NP_001306933.1	rac GTPase-activating protein 1 isoform a
NM_001320005.2	NP_001306934.1	rac GTPase-activating protein 1 isoform b
NM_001320006.2	NP_001306935.1	rac GTPase-activating protein 1 isoform c
NM_001320007.2	NP_001306936.1	rac GTPase-activating protein 1 isoform d
NM_013277.5	NP_037409.2	rac GTPase-activating protein 1 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GTPase activator activity	IDA IDA: 通过直接分析推断	10979956	GOA
enables GTPase activator activity	IMP IMP: 通过突变表型推断	15642749	GOA
enables alpha-tubulin binding	IDA IDA: 通过直接分析推断	11085985	GOA
enables beta-tubulin binding	IDA IDA: 通过直接分析推断	11085985	GOA
enables gamma-tubulin binding	IDA IDA: 通过直接分析推断	11085985	GOA
enables microtubule binding	IDA IDA: 通过直接分析推断	11782313	GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: 通过直接分析推断	23235882	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11278976	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	19468302	GOA
enables protein-macromolecule adaptor activity	IDA IDA: 通过直接分析推断	11782313	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in actomyosin contractile ring assembly	IMP IMP: 通过突变表型推断	16129829	GOA
involved in erythrocyte differentiation	IMP IMP: 通过突变表型推断	34818416	GOA
involved in mitotic cytokinesis	IDA IDA: 通过直接分析推断	11085985	GOA
involved in mitotic cytokinesis	IMP IMP: 通过突变表型推断	16236794	GOA
involved in mitotic spindle midzone assembly	IDA IDA: 通过直接分析推断	16103226	GOA
involved in positive regulation of cytokinesis	IDA IDA: 通过直接分析推断	16103226	GOA
involved in positive regulation of cytokinesis	IMP IMP: 通过突变表型推断	11782313	GOA
involved in regulation of attachment of spindle microtubules to kinetochore	IMP IMP: 通过突变表型推断	15642749	GOA
involved in spermatogenesis	IEP IEP: 通过表达模式推断	12590651	GOA
involved in sulfate transmembrane transport	IDA IDA: 通过直接分析推断	11278976	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of centralspindlin complex	IDA IDA: 通过直接分析推断	11782313	GOA
located in cleavage furrow	IDA IDA: 通过直接分析推断	16103226	GOA
located in cytoplasmic side of plasma membrane	IDA IDA: 通过直接分析推断	23235882	GOA
located in midbody	IDA IDA: 通过直接分析推断	11782313	GOA
located in mitotic spindle	IDA IDA: 通过直接分析推断	16103226	GOA
located in mitotic spindle	IMP IMP: 通过突变表型推断	15642749	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11085985	GOA
located in spindle	IDA IDA: 通过直接分析推断	18445686	GOA
located in spindle midzone	IDA IDA: 通过直接分析推断	19468302	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RACGAP1 蛋白结构

C1_1

RhoGAP

0
100
200
300
400
500
632 a.a.

蛋白主名

其他名称

rac GTPase-activating protein 1

male germ cell RacGap

RACGAP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RACGAP1	Q9H0H5	ECT2	Homo sapiens	Q9H8V3	Anti Bait CoIP	18201571
种属内	RACGAP1	Q9H0H5	ECT2	Homo sapiens	Q9H8V3	ITC	25068414
种属内	RACGAP1	Q9H0H5	ECT2	Homo sapiens	Q9H8V3	Anti Bait CoIP	19468302
种属内	RACGAP1	Q9H0H5	SLC26A8	Homo sapiens	Q96RN1	Pull Down	11278976
种属内	RACGAP1	Q9H0H5	KIF23	Homo sapiens	Q02241	Anti Tag CoIP	35271311
种属内	RACGAP1	Q9H0H5	KIF23	Homo sapiens	Q02241	IF	11782313
种属内	RACGAP1	Q9H0H5	KIF23	Homo sapiens	Q02241	Anti Tag CoIP	26496610
种属内	RACGAP1	Q9H0H5	KIF23	Homo sapiens	Q02241	Anti Tag CoIP	33961781
种属内	RACGAP1	Q9H0H5	KIF23	Homo sapiens	Q02241	Anti Tag CoIP	32203420
种属内	RACGAP1	Q9H0H5	KIF23	Homo sapiens	Q02241	Anti Bait CoIP	11782313
种属内	RACGAP1	Q9H0H5	MORF4L1	Homo sapiens	Q9UBU8	Y2H Prey Pooling	25416956
种属内	RACGAP1	Q9H0H5	PLK1	Homo sapiens	P53350	Anti Bait CoIP	19468302
种属内	RACGAP1	Q9H0H5	CTNNA1	Homo sapiens	P35221	Anti Bait CoIP	22750944
种属内	RACGAP1	Q9H0H5	TRAF3IP3	Homo sapiens	Q9Y228	Validated Y2H	32296183
种属内	RACGAP1	Q9H0H5	RAB11FIP3	Homo sapiens	O75154	Competition Binding	18511905

种属间: 跨种属相互作用 种属内: 同种属相互作用

RACGAP1 抗体

目录号	产品名	应用	反应物种
HY-P83136	RACGAP1 Antibody (YA2881)	WB, IHC-P, ICC/IF	Human

关联疾病

疾病名称

别名

Anemia, Congenital Dyserythropoietic, Type Iiib, Autosomal Recessive

CDAN3B	Cda, Type Iiib
Anemia, Congenital Dyserythropoietic, 3b, Autosomal Recessive

Cataract 36

CTRCT36	Catc4
Autosomal Recessive Congenital Cataract 4	Cataract, Autosomal Recessive Congenital 4
Cataract, Type 36

Anemia, Congenital Dyserythropoietic, Type Iiia

Congenital Dyserythropoietic Anemia, Type Iii	Cdan3
Congenital Dyserythropoietic Anemia Type Iii	Cda Iii
Congenital Dyserythropoietic Anemia Type 3	CDAN3A
Dyserythropoietic Anemia, Congenital, Type Iiia	Cda, Type Iiia
Anemia, Congenital Dyserythropoietic, Type Iii	Anemia With Multinucleated Erythroblasts
Cda Type 3	Cda Type Iii
Dyserythropoietic Anemia, Congenital Type 3	Cda, Type Iii
Erythroreticulosis, Hereditary Benign	Anaemia With Multinucleated Erythroblasts
Congenital Dyserythropoietic Anaemia Type 3	Congenital Dyserythropoietic Anaemia Type Iii
Hereditary Benign Erythroreticulosis	Anemia, Congenital Dyserythropoietic, 3a
Anemia With Multinucleated Erythroblasts Erythroreticulosis, Hereditary Benign

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Uterine Body Mixed Cancer

Malignant Mixed Tumor Of Corpus Uteri

Malignant Mixed Tumor, Not Otherwise Specified

Uterine Carcinosarcoma

Carcinosarcoma Of The Corpus Uteri	Mixed Mullerian Sarcoma Of Uterus
Malignant Mixed Müllerian Tumor Of The Corpus Uteri	Malignant Mixed Müllerian Tumor Of Corpus Uteri
Mixed Müllerian Cancer Of Corpus Uteri	Malignant Mixed Mullerian Tumor Of The Corpus Uteri
Mixed Mullerian Cancer Of Corpus Uteri	Uterine Corpus Carcinosarcoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11594	RACGAP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	RACGAP1	VGNC	VGNC:33675
Macaca mulatta	RACGAP1	VGNC	VGNC:100098
Felis catus	RACGAP1	VGNC	VGNC:69210
Rattus norvegicus	RACGAP1	RGD	RGD:1305912
Canis familiaris	RACGAP1	VGNC	VGNC:45308
Mus musculus	RACGAP1	MGD	MGI:1349423

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RACGAP1 - Rac GTPase activating protein 1 Gene

关于 RACGAP1

功能概要

RACGAP1 基因产物(12)

RACGAP1 蛋白结构

RACGAP1 蛋白互作信息

RACGAP1 抗体

关联疾病

直系同源

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RACGAP1 - Rac GTPase activating protein 1 Gene

关于 RACGAP1

功能概要

RACGAP1 基因产物(12)

RACGAP1 蛋白结构

RACGAP1 蛋白互作信息

RACGAP1 抗体

关联疾病

相关产品

直系同源

热门区域

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F

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Q

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