2. Gene
  3. SLC26A8 - solute carrier family 26 member 8 Gene

SLC26A8 - solute carrier family 26 member 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 26 成员 8

种属: Homo sapiens

同用名: TAT1; SPGF3

基因 ID: 116369 | 基因类型: protein coding

关于 SLC26A8

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,943,516-36,024,641 (from NCBI)

This gene has 8 transcripts (splice variants), 111 orthologues, 9 paralogues and is associated with 2 phenotypes. Restricted expression toward testis (RPKM 27.9).

功能概要

该基因编码阴离子转运蛋白 SLC26 基因家族的成员。家族成员在基因结构和蛋白质长度方面非常保守，但具有明显不同的组织表达模式。该基因的表达似乎仅限于精母细胞。已经描述了编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2010 年 7 月]

This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. The expression of this gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2010]

SLC26A8 基因产物(3)

mRNA Protein Name
NM_001193476.2 NP_001180405.1 testis anion transporter 1 isoform a
NM_052961.4 NP_443193.1 testis anion transporter 1 isoform a
NM_138718.3 NP_619732.2 testis anion transporter 1 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chloride channel activity IDA
IDA: 通过直接分析推断
11834742 GOA
enables oxalate transmembrane transporter activity IDA
IDA: 通过直接分析推断
11834742 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11278976 GOA
enables sulfate transmembrane transporter activity IDA
IDA: 通过直接分析推断
11834742 GOA
enables sulfate:chloride antiporter activity IDA
IDA: 通过直接分析推断
11278976 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chloride transport IDA
IDA: 通过直接分析推断
11278976 GOA
involved in oxalate transport IDA
IDA: 通过直接分析推断
11834742 GOA
involved in sulfate transmembrane transport IDA
IDA: 通过直接分析推断
11278976 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
11278976 GOA
located in sperm annulus IDA
IDA: 通过直接分析推断
17517695 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC26A8 蛋白结构

(77 - 162)

Sulfate_transp

Sulfate_transp: Sulfate permease family (212 - 487)

STAS

STAS: STAS domain (544 - 791)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 970 a.a.
蛋白主名 其他名称

testis anion transporter 1

anion transporter/exchanger-8

SLC26A8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SLC26A8 Q96RN1 RACGAP1 Homo sapiens Q9H0H5
Y2H
11278976
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spermatogenic Failure 3

SPGF3

Azoospermia, Nonobstructive
Non-Syndromic Male Infertility Due To Sperm Motility Disorder

Non-Syndromic Male Infertility Due Asthenozoospermia
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Diastrophic Dysplasia

Diastrophic Dwarfism

DTD

Dd

Diastrophic Dysplasia, Broad Bone-Platyspondylic Variant

Dysplasia, Diastrophic

Diastrophic Dysplasia Variant
Infertility
Pendred Syndrome

Goiter-Deafness Syndrome

Deafness With Goiter

PDS

Thyroid Dyshormonogenesis 2b

Tdh2b

Autosomal Recessive Sensorineural Hearing Impairment And Goiter

Pendred'S Syndrome

Thyroid Hormonogenesis, Genetic Defect In, 2b

Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2b

Congenital Hypothyroidism Due To Dyshormonogenesis 2b

Genetic Defect In Thyroid Hormonogenesis 2b

Autosomal Recessive Sensorineural Hearing Impairment, Enlarged Vestibular Aqueduct, And Goiter

Goiter-Hearing Loss Syndrome

Goitre-Deafness Syndrome

Goitre Deafness
Atelosteogenesis

Atelosteogenesis, Type 1
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Osteochondrodysplasia

Skeletal Dysplasia

Chondrodystrophy

Congenital Anomaly Of Cartilage

Osteochondrodysplasias

Cartilage Development Disorder

Osteochondrodysplasia Syndrome

Dysplasia, Skeletal

Mucopolysaccharidosis Iv
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13142 SLC26A8 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SLC26A8 RGD RGD:1308898
Mus musculus SLC26A8 MGD MGI:2385046
Bos taurus SLC26A8 VGNC VGNC:34783
Macaca mulatta SLC26A8 VGNC VGNC:77479
Felis catus SLC26A8 VGNC VGNC:65286
Canis familiaris SLC26A8 VGNC VGNC:46327
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