MORF4L1 - mortality factor 4 like 1 Gene

中文名称：死亡率 4 等于 1

种属: Homo sapiens

同用名: Eaf3; MEAF3; MRG15; FWP006; S863-6; HsT17725; MORFRG15

基因 ID: 10933 | 基因类型: protein coding

关于 MORF4L1

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,872,890-78,898,139 (from NCBI)

This gene has 23 transcripts (splice variants), 280 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 192.5), brain (RPKM 119.7) and 25 other tissues.

功能概要

启用蛋白质 N 末端结合活性。通过同源重组和组蛋白修饰参与双链断裂修复。位于核斑点。 NuA4 组蛋白乙酰转移酶复合物和 Sin3 复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein N-terminus binding activity. Involved in double-strand break repair via homologous recombination and histone modification. Located in nuclear speck. Part of NuA4 Histone Acetyltransferase complex and Sin3 complex. [provided by Alliance of Genome Resources, Apr 2022]

MORF4L1 基因产物(5)

mRNA	Protein	Name
NM_001265603.2	NP_001252532.1	mortality factor 4-like protein 1 isoform 3
NM_001265604.2	NP_001252533.1	mortality factor 4-like protein 1 isoform 3
NM_001265605.2	NP_001252534.1	mortality factor 4-like protein 1 isoform 3
NM_006791.4	NP_006782.1	mortality factor 4-like protein 1 isoform 1
NM_206839.3	NP_996670.1	mortality factor 4-like protein 1 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	12963728	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in double-strand break repair via homologous recombination	IDA IDA: 通过直接分析推断	20332121	GOA
involved in positive regulation of double-strand break repair via homologous recombination	IDA IDA: 通过直接分析推断	27153538	GOA
involved in regulation of cell cycle	IMP IMP: 通过突变表型推断	27153538	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of NuA4 histone acetyltransferase complex	IDA IDA: 通过直接分析推断	14966270	GOA
part of Sin3-type complex	IDA IDA: 通过直接分析推断	14966270	GOA
part of nucleosome	IDA IDA: 通过直接分析推断	27153538	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MORF4L1 蛋白结构

Tudor-knot

MRG

0
100
200
300
362 a.a.

蛋白主名

其他名称

mortality factor 4-like protein 1

Esa1p-associated factor 3 homolog

MORF4L1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	MORF4L1	Q9UBU8	FLJ13057	Homo sapiens	Q53SE7	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	BEND7	Homo sapiens	Q8N7W2-2	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	HMBOX1	Homo sapiens	Q6NT76-2	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	ZBTB10	Homo sapiens	Q96DT7	Y2H Prey Pooling	25416956
Intra	MORF4L1	Q9UBU8	ZBTB10	Homo sapiens	Q96DT7	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	CAMK2B	Homo sapiens	Q13554	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	CAMK2B	Homo sapiens	Q13554	Y2H Prey Pooling	25416956
Intra	MORF4L1	Q9UBU8	HMBOX1	Homo sapiens	Q6NT76	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	HMBOX1	Homo sapiens	Q6NT76	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	MEOX1	Homo sapiens	P50221	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	ARRDC3	Homo sapiens	Q96B67	Y2H Prey Pooling	25416956
Intra	MORF4L1	Q9UBU8	ARRDC3	Homo sapiens	Q96B67	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	TNIP1	Homo sapiens	Q15025	Y2H Array	31515488
Intra	MORF4L1	Q9UBU8	ZBTB9	Homo sapiens	Q96C00	Y2H Array	31515488
Intra	MORF4L1	Q9UBU8	MRGBP	Homo sapiens	Q9NV56	TAP	24981860
Intra	MORF4L1	Q9UBU8	MRGBP	Homo sapiens	Q9NV56	Anti Tag CoIP	33961781
Intra	MORF4L1	Q9UBU8	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	MORF4L1	Q9UBU8	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	RACGAP1	Homo sapiens	Q9H0H5	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	RACGAP1	Homo sapiens	Q9H0H5	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	TFCP2	Homo sapiens	Q12800	Y2H Prey Pooling	25416956
Intra	MORF4L1	Q9UBU8	TFCP2	Homo sapiens	Q12800	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	TFCP2	Homo sapiens	Q12800	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	TNNT1	Homo sapiens	P13805	Y2H Prey Pooling	25416956
Intra	MORF4L1	Q9UBU8	TNNT1	Homo sapiens	P13805	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	FXR2	Homo sapiens	P51116	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	FXR2	Homo sapiens	P51116	Y2H Prey Pooling	25416956
Intra	MORF4L1	Q9UBU8	PBXIP1	Homo sapiens	Q96AQ6	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	NAV2	Homo sapiens	Q8IVL1	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	IKZF1	Homo sapiens	Q13422	Y2H Prey Pooling	25416956
Intra	MORF4L1	Q9UBU8	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Prey Pooling	25416956
Intra	MORF4L1	Q9UBU8	MRFAP1L1	Homo sapiens	Q96HT8	MAPPIT	25416956
Intra	MORF4L1	Q9UBU8	MRFAP1L1	Homo sapiens	Q96HT8	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Pooling	16189514
Intra	MORF4L1	Q9UBU8	MRFAP1L1	Homo sapiens	Q96HT8	Anti Tag CoIP	33961781
Intra	MORF4L1	Q9UBU8	MRFAP1L1	Homo sapiens	Q96HT8	TAP	24981860
Intra	MORF4L1	Q9UBU8	MRFAP1	Homo sapiens	Q9Y605	Anti Tag CoIP	33961781
Intra	MORF4L1	Q9UBU8	MRFAP1	Homo sapiens	Q9Y605	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	MRFAP1	Homo sapiens	Q9Y605	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	MRFAP1	Homo sapiens	Q9Y605	Y2H Prey Pooling	25416956
Intra	MORF4L1	Q9UBU8	MRFAP1	Homo sapiens	Q9Y605	TAP	24981860

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Paraneoplastic Cerebellar Degeneration

Pcd	Paraneoplastic Cerebellar Ataxia
Rapidely Progressive Cerebellar Syndrome	Subacute Cerebellar Degeneration

Wolf-Hirschhorn Syndrome

Pitt-Rogers-Danks Syndrome	WHS
Chromosome 4p16.3 Deletion Syndrome	Wittwer Syndrome
4p- Syndrome	Pitt Syndrome
4p Deletion Syndrome	Distal Deletion 4p
Distal Monosomy 4p	Telomeric Deletion 4p
Prds	4p Syndrome
Chromosome 4p Syndrome	Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation
Wolf Syndrome	Chromosome 4p Deletion Syndrome
Chromosome 4p Monosomy	Del Syndrome
Monosomy 4p	Partial Monosomy 4p
Chromosome 4 Short Arm Deletion

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08593	MORF4L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	MORF4L1	VGNC	VGNC:56001
Rattus norvegicus	MORF4L1	RGD	RGD:1307938
Felis catus	MORF4L1	VGNC	VGNC:97512
Mus musculus	MORF4L1	MGD	MGI:1096551
Macaca mulatta	MORF4L1	VGNC	VGNC:84396

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