1. Gene
  2. MRGBP - MRG domain binding protein Gene

MRGBP - MRG domain binding protein Gene

中文名称:MRG 结构域结合蛋白

种属: Homo sapiens

同用名: Eaf7; URCC4; MRG15BP; C20orf20

基因 ID: 55257 | 基因类型: protein coding

关于 MRGBP

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:62,796,473-62,801,729 (from NCBI)

This gene has 1 transcript (splice variant) and 195 orthologues. Broad expression in testis (RPKM 23.2), ovary (RPKM 4.6) and 24 other tissues.

功能概要

预计参与组蛋白乙酰化和 RNA 聚合酶 II 的转录调节。位于核质中。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to be involved in histone acetylation and regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MRGBP 基因产物(1)

mRNA Protein Name
NM_018270.6 NP_060740.1 MRG/MORF4L-binding protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12963728 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of double-strand break repair via homologous recombination IDA
IDA: 通过直接分析推断
27153538 GOA
involved in regulation of cell cycle IMP
IMP: 通过突变表型推断
27153538 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NuA4 histone acetyltransferase complex IDA
IDA: 通过直接分析推断
27153538 GOA
part of nucleosome IDA
IDA: 通过直接分析推断
27153538 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MRGBP 蛋白结构

Eaf7

Eaf7: Chromatin modification-related protein EAF7 (34 - 113)

  • 0
  • 100
  • 204 a.a.
蛋白主名 其他名称

MRG/MORF4L-binding protein

MRG-binding protein

MRGBP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MRGBP Q9NV56 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
32296183
种属内
MRGBP Q9NV56 KRTAP10-7 Homo sapiens P60409
Y2H Array
32296183
种属内
MRGBP Q9NV56 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
种属内
MRGBP Q9NV56 MORF4L1 Homo sapiens Q9UBU8-2
Anti Tag CoIP
28514442
种属内
MRGBP Q9NV56 MORF4L1 Homo sapiens Q9UBU8-2
Validated Y2H
25416956
种属内
MRGBP Q9NV56 MORF4L1 Homo sapiens Q9UBU8-2
Y2H Prey Pooling
32296183
种属内
MRGBP Q9NV56 MORF4L1 Homo sapiens Q9UBU8-2
Validated Y2H
32296183
种属内
MRGBP Q9NV56 MORF4L1 Homo sapiens Q9UBU8-2
Y2H Array
32296183
种属内
MRGBP Q9NV56 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
种属内
MRGBP Q9NV56 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
种属内
MRGBP Q9NV56 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Prey Pooling
32296183
种属内
MRGBP Q9NV56 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Array
32296183
种属内
MRGBP Q9NV56 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Prey Pooling
32296183
种属内
MRGBP Q9NV56 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Array
32296183
种属内
MRGBP Q9NV56 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
种属内
MRGBP Q9NV56 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
种属内
MRGBP Q9NV56 ANP32E Homo sapiens Q9BTT0
Pull Down
24463511
种属内
MRGBP Q9NV56 MORF4L1 Homo sapiens Q9UBU8
Y2H Prey Pooling
25416956
种属内
MRGBP Q9NV56 MORF4L1 Homo sapiens Q9UBU8
Anti Tag CoIP
15647280
种属内
MRGBP Q9NV56 MORF4L1 Homo sapiens Q9UBU8
Anti Tag CoIP
12963728
种属内
MRGBP Q9NV56 MORF4L1 Homo sapiens Q9UBU8
Anti Bait CoIP
16230350
种属内
MRGBP Q9NV56 MORF4L1 Homo sapiens Q9UBU8
Anti Tag CoIP
33961781
种属内
MRGBP Q9NV56 MORF4L1 Homo sapiens Q9UBU8
Validated Y2H
25416956
种属内
MRGBP Q9NV56 MORF4L1 Homo sapiens Q9UBU8
Y2H Array
25416956
种属内
MRGBP Q9NV56 MORF4L2 Homo sapiens Q15014
Anti Tag CoIP
12963728
种属内
MRGBP Q9NV56 MORF4L2 Homo sapiens Q15014
Anti Tag CoIP
28514442
种属内
MRGBP Q9NV56 MORF4L2 Homo sapiens Q15014
Y2H Array
25416956
种属内
MRGBP Q9NV56 MORF4L2 Homo sapiens Q15014
Anti Bait CoIP
16230350
种属内
MRGBP Q9NV56 MORF4L2 Homo sapiens Q15014
Anti Tag CoIP
33961781
种属内
MRGBP Q9NV56 MORF4L2 Homo sapiens Q15014
Y2H Array
32296183
种属内
MRGBP Q9NV56 MORF4L2 Homo sapiens Q15014
Y2H Prey Pooling
25416956
种属内
MRGBP Q9NV56 MORF4L2 Homo sapiens Q15014
Y2H Prey Pooling
32296183
种属内
MRGBP Q9NV56 MORF4L2 Homo sapiens Q15014
Anti Tag CoIP
15647280
种属内
MRGBP Q9NV56 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
种属内
MRGBP Q9NV56 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Intellectual Developmental Disorder, Autosomal Dominant 5

MRD5

Autosomal Dominant Non-Syndromic Intellectual Disability 5

Intellectual Disability, Autosomal Dominant 5

Mental Retardation, Autosomal Dominant 5

Autosomal Dominant Intellectual Developmental Disorder 5

Syngap1-Related Non-Syndromic Intellectual Disability

Autosomal Dominant Intellectual Disability 5

Syngap1 Syndrome

Syngap1-Related Nsid

Syngap1 Gene Mutation Linked To Intellectual Disability, Schizophrenia And Autism

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus MRGBP MGD MGI:1920497
Canis familiaris MRGBP VGNC VGNC:54654
Felis catus MRGBP VGNC VGNC:81122
Rattus norvegicus MRGBP RGD RGD:1308612
Macaca mulatta MRGBP VGNC VGNC:95363
Bos taurus MRGBP VGNC VGNC:31602