FXR2 - FMR1 autosomal homolog 2 Gene

中文名称：FMR1 常染色体同系物 2

种属: Homo sapiens

同用名: FXR2P; FMR1L2

基因 ID: 9513 | 基因类型: protein coding

关于 FXR2

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,591,230-7,614,897 (from NCBI)

This gene has 8 transcripts (splice variants), 193 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 19.4), testis (RPKM 17.3) and 25 other tissues.

功能概要

该基因编码的蛋白是一种含有两个 KH 结构域和一个 RCG 盒的 RNA 结合蛋白，与 FMRP 和 FXR1 相似。它与多聚核糖体结合，主要与 60S 大核糖体亚基结合。这种编码的蛋白质可能与 FMRP 和 FXR1 自我结合或相互作用。它可能在脆性 X 认知障碍综合征的发展中起作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X cognitive disability syndrome. [provided by RefSeq, Jul 2008]

FXR2 基因产物(1)

mRNA	Protein	Name
NM_004860.4	NP_004851.2	RNA-binding protein FXR2

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	7489725	GOA
enables protein heterodimerization activity	IDA IDA: 通过直接分析推断	7489725	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	7489725	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	7489725	GOA
is active in cytoplasmic stress granule	IDA IDA: 通过直接分析推断	12417522	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FXR2 蛋白结构

Agenet

KH_1

FXMRP1_C_core

0
200
400
600
673 a.a.

蛋白主名

其他名称

RNA-binding protein FXR2

fragile X mental retardation syndrome-related protein 2

FXR2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FXR2	P51116	HMBOX1	Homo sapiens	Q6NT76-2	Y2H Prey Pooling	25416956
种属内	FXR2	P51116	HMBOX1	Homo sapiens	Q6NT76-2	Validated Y2H	25416956
种属内	FXR2	P51116	FMR1	Homo sapiens	Q06787-8	Validated Y2H	25416956
种属内	FXR2	P51116	INPP5J	Homo sapiens	Q15735	Validated Y2H	32296183
种属内	FXR2	P51116	MIA3	Homo sapiens	Q5JRA6-2	Y2H Prey Pooling	25416956
种属内	FXR2	P51116	SYT6	Homo sapiens	Q5T7P8-2	Y2H Prey Pooling	25416956
种属内	FXR2	P51116	SYT6	Homo sapiens	Q5T7P8-2	Y2H Array	25416956
种属内	FXR2	P51116	SYT6	Homo sapiens	Q5T7P8-2	Validated Y2H	25416956
种属内	FXR2	P51116	SYT6	Homo sapiens	Q5T7P8-2	Validated Y2H	32296183
种属内	FXR2	P51116	MORF4L1	Homo sapiens	Q9UBU8-2	Validated Y2H	32296183
种属内	FXR2	P51116	BAZ2B	Homo sapiens	Q9UIF8-2	Y2H Prey Pooling	25416956
种属内	FXR2	P51116	MRPL43	Homo sapiens	Q8N983	Y2H Array	25416956
种属内	FXR2	P51116	MFAP1	Homo sapiens	P55081	Y2H Prey Pooling	25416956
种属内	FXR2	P51116	MFAP1	Homo sapiens	P55081	Validated Y2H	32296183
种属内	FXR2	P51116	NEXN	Homo sapiens	Q0ZGT2-4	Validated Y2H	32296183
种属内	FXR2	P51116	IGFN1	Homo sapiens	Q86VF2-5	Validated Y2H	32296183
种属内	FXR2	P51116	FMR1	Homo sapiens	Q8IXW7	Validated Y2H	32296183
种属内	FXR2	P51116	EIF4G1	Homo sapiens	Q04637-9	Validated Y2H	32296183
种属内	FXR2	P51116	BLK	Homo sapiens	P51451	Validated Y2H	32296183
种属间	FXR2	P51116	P0DTD1-PRO_0000449621	SARS-CoV-2	P0DTD1-PRO_0000449621	Y2H Array	36217030
种属内	FXR2	P51116	HMBOX1	Homo sapiens	Q6NT76	Y2H Array	25416956
种属内	FXR2	P51116	HMBOX1	Homo sapiens	Q6NT76	Y2H Prey Pooling	25416956
种属内	FXR2	P51116	HMBOX1	Homo sapiens	Q6NT76	Validated Y2H	25416956
种属内	FXR2	P51116	PAF1	Homo sapiens	Q8N7H5	Y2H Array	25416956
种属内	FXR2	P51116	ZMAT2	Homo sapiens	Q96NC0	Y2H Prey Pooling	25416956
种属内	FXR2	P51116	ZMAT2	Homo sapiens	Q96NC0	Validated Y2H	25416956
种属内	FXR2	P51116	ZMAT2	Homo sapiens	Q96NC0	Validated Y2H	32296183
种属内	FXR2	P51116	ZMAT2	Homo sapiens	Q96NC0	Y2H Array	25416956
种属内	FXR2	P51116	PRAM1	Homo sapiens	Q96QH2	Y2H Prey Pooling	25416956
种属内	FXR2	P51116	PRAM1	Homo sapiens	Q96QH2	Validated Y2H	25416956
种属内	FXR2	P51116	PRAM1	Homo sapiens	Q96QH2	Validated Y2H	32296183
种属内	FXR2	P51116	LCP2	Homo sapiens	Q13094	Validated Y2H	32296183
种属内	FXR2	P51116	LCP2	Homo sapiens	Q13094	Y2H Array	25416956
种属内	FXR2	P51116	UBAP2L	Homo sapiens	Q14157	Validated Y2H	32296183
种属内	FXR2	P51116	MCRS1	Homo sapiens	Q96EZ8	Y2H Pooling	16189514
种属内	FXR2	P51116	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
种属内	FXR2	P51116	CAMK2D	Homo sapiens	Q13557	Y2H Array	25416956
种属内	FXR2	P51116	BYSL	Homo sapiens	Q13895	Y2H Prey Pooling	25416956
种属内	FXR2	P51116	BYSL	Homo sapiens	Q13895	Validated Y2H	32296183
种属内	FXR2	P51116	FMR1	Homo sapiens	Q06787	Y2H Pooling	21653829
种属内	FXR2	P51116	FMR1	Homo sapiens	Q06787	Anti Tag CoIP	33961781
种属内	FXR2	P51116	FMR1	Homo sapiens	Q06787	TAP	24981860
种属内	FXR2	P51116	CDKL3	Homo sapiens	Q8IVW4	Validated Y2H	32296183
种属内	FXR2	P51116	CDKL3	Homo sapiens	Q8IVW4	Y2H Array	25416956
种属内	FXR2	P51116	MORF4L1	Homo sapiens	Q9UBU8	Validated Y2H	25416956
种属内	FXR2	P51116	MEAF6	Homo sapiens	Q9HAF1	Y2H Array	19060904
种属内	FXR2	P51116	MEAF6	Homo sapiens	Q9HAF1	Y2H Pooling	19060904
种属内	FXR2	P51116	MEAF6	Homo sapiens	Q9HAF1	Y2H Pooling	16189514
种属内	FXR2	P51116	AP1M1	Homo sapiens	Q9BXS5	Y2H Prey Pooling	25416956
种属内	FXR2	P51116	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	32296183
种属内	FXR2	P51116	AP1M1	Homo sapiens	Q9BXS5	Y2H Array	25416956
种属内	FXR2	P51116	CWF19L2	Homo sapiens	Q2TBE0	Validated Y2H	32296183
种属内	FXR2	P51116	SRPK2	Homo sapiens	P78362	Y2H Prey Pooling	25416956
种属内	FXR2	P51116	SRPK2	Homo sapiens	P78362	Validated Y2H	25416956
种属内	FXR2	P51116	FAM90A1	Homo sapiens	Q86YD7	Y2H Array	25416956
种属内	FXR2	P51116	FAM90A1	Homo sapiens	Q86YD7	Y2H Prey Pooling	25416956
种属内	FXR2	P51116	PIM1	Homo sapiens	P11309	Y2H Prey Pooling	25416956
种属内	FXR2	P51116	PAICS	Homo sapiens	P22234	Y2H Pooling	16189514
种属内	FXR2	P51116	PAICS	Homo sapiens	P22234	Y2H Array	19060904
种属内	FXR2	P51116	PAICS	Homo sapiens	P22234	Y2H Pooling	19060904
种属内	FXR2	P51116	PTS	Homo sapiens	Q03393	Y2H Array	31515488
种属内	FXR2	P51116	RABAC1	Homo sapiens	Q9UI14	Y2H Pooling	16189514
种属内	FXR2	P51116	FBP1	Homo sapiens	P09467	Y2H Array	31515488
种属内	FXR2	P51116	FXR1	Homo sapiens	P51114	Y2H Pooling	21653829
种属内	FXR2	P51116	FXR1	Homo sapiens	P51114	Anti Tag CoIP	33961781
种属内	FXR2	P51116	FXR1	Homo sapiens	P51114	Anti Tag CoIP	28514442
种属内	FXR2	P51116	ARL6IP1	Homo sapiens	Q15041	Y2H Pooling	16189514
种属内	FXR2	P51116	ARL6IP1	Homo sapiens	Q15041	Y2H Array	19060904
种属内	FXR2	P51116	ARL6IP1	Homo sapiens	Q15041	Y2H Pooling	19060904
种属内	FXR2	P51116	ZBTB22	Homo sapiens	O15209	Validated Y2H	25416956
种属内	FXR2	P51116	ZBTB22	Homo sapiens	O15209	Y2H Array	25416956
种属内	FXR2	P51116	POM121	Homo sapiens	Q96HA1	Y2H Array	25416956
种属内	FXR2	P51116	POM121	Homo sapiens	Q96HA1	Y2H	21516116
种属内	FXR2	P51116	POM121	Homo sapiens	Q96HA1	Y2H Prey Pooling	25416956
种属内	FXR2	P51116	CBS	Homo sapiens	P35520	Y2H Array	31515488
种属内	FXR2	P51116	PCBD1	Homo sapiens	P61457	Y2H Array	25416956
种属内	FXR2	P51116	LDOC1	Homo sapiens	O95751	Y2H Pooling	16189514
种属内	FXR2	P51116	NIF3L1	Homo sapiens	Q9GZT8	Validated Y2H	25416956
种属内	FXR2	P51116	NME1	Homo sapiens	P15531	Y2H Array	31515488
种属内	FXR2	P51116	MBIP	Homo sapiens	Q9NS73	Y2H Array	19060904
种属内	FXR2	P51116	MBIP	Homo sapiens	Q9NS73	Y2H Pooling	16189514
种属内	FXR2	P51116	MBIP	Homo sapiens	Q9NS73	Y2H Pooling	19060904
种属内	FXR2	P51116	NT5C2	Homo sapiens	P49902	Y2H Pooling	16189514
种属内	FXR2	P51116	MMTAG2	Homo sapiens	Q9BU76	Validated Y2H	25416956
种属内	FXR2	P51116	MMTAG2	Homo sapiens	Q9BU76	Validated Y2H	32296183
种属内	FXR2	P51116	LASP1	Homo sapiens	Q14847	Y2H Prey Pooling	25416956
种属内	FXR2	P51116	LASP1	Homo sapiens	Q14847	Validated Y2H	25416956
种属内	FXR2	P51116	LASP1	Homo sapiens	Q14847	Y2H Array	25416956
种属内	FXR2	P51116	C10orf62	Homo sapiens	Q5T681	Y2H Prey Pooling	25416956
种属内	FXR2	P51116	C10orf62	Homo sapiens	Q5T681	Y2H Pooling	16189514
种属内	FXR2	P51116	SYTL4	Homo sapiens	Q96C24	Validated Y2H	32296183
种属内	FXR2	P51116	SYTL4	Homo sapiens	Q96C24	Y2H Array	25416956
种属内	FXR2	P51116	SYTL4	Homo sapiens	Q96C24	Y2H Prey Pooling	25416956
种属内	FXR2	P51116	SYTL4	Homo sapiens	Q96C24	Validated Y2H	25416956
种属内	FXR2	P51116	LCMT1	Homo sapiens	Q9UIC8	Y2H Pooling	16189514
种属内	FXR2	P51116	CEP55	Homo sapiens	Q53EZ4	Validated Y2H	25416956
种属内	FXR2	P51116	CEP55	Homo sapiens	Q53EZ4	Y2H Prey Pooling	25416956
种属内	FXR2	P51116	ZNF232	Homo sapiens	Q9UNY5	Validated Y2H	32296183
种属内	FXR2	P51116	SCEL	Homo sapiens	O95171	Y2H Prey Pooling	25416956
种属内	FXR2	P51116	TBC1D22B	Homo sapiens	Q9NU19	Y2H Prey Pooling	25416956
种属内	FXR2	P51116	TBC1D22B	Homo sapiens	Q9NU19	Y2H Array	29892012

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Fragile X Syndrome

FXS	Martin-Bell Syndrome
Fraxa Syndrome	Marker X Syndrome
X-Linked Mental Retardation And Macroorchidism	Fragile X Mental Retardation Syndrome
Fra Syndrome	Mental Retardation, X-Linked, Associated With Marxq28
X-Linked Intellectual Disability And Macroorchidism	Frax Syndrome
Symptomatic Form Of Fragile X Syndrome In Female Carriers	Fragile-X Syndrome
Fraxe Syndrome

Premature Ovarian Failure 1

Ovarian Failure, Premature	Fmr1-Related Primary Ovarian Insufficiency
Fragile X-Associated Primary Ovarian Insufficiency	POF1
Pofx	Hypergonadotropic Ovarian Failure, X-Linked
Pof	Primary Ovarian Insufficiency, Fragile X-Associated
Primary Ovarian Insufficiency 1	Ovarian Failure Premature
Premature Ovarian Failure, X-Linked	Fragile X Premature Ovarian Failure
Fmr1-Related Premature Ovarian Failure	Familial Premature Ovarian Failure
Idiopathic Familial Premature Ovarian Failure	Fxpoi
X-Linked Hypergonadotropic Ovarian Failure	Hypergonadotropic Ovarian Failure X-Linked
Poi	Premature Ovarian Failure X-Linked
Primary Ovarian Insufficiency	Premature Ovarian Failure-1
Ovarian Failure, Premature, Type 1	Premature Ovarian Failure, Familial
Premature Menopause	Primary Hypogonadism
Turner Syndrome

Fragile X-Associated Tremor/Ataxia Syndrome

Fxtas Syndrome	Fragile X Tremor/Ataxia Syndrome
Fxtas

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05164	FXR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	FXR2	RGD	RGD:1307011
Bos taurus	FXR2	VGNC	VGNC:55832
Mus musculus	FXR2	MGD	MGI:1346074
Macaca mulatta	FXR2	VGNC	VGNC:99153
Canis familiaris	FXR2	VGNC	VGNC:53386
Felis catus	FXR2	VGNC	VGNC:99059

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