PAICS - phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase Gene

中文名称：磷酸核糖氨基咪唑羧化酶和磷酸核糖氨基咪唑琥珀酰甲酰胺合酶

种属: Homo sapiens

同用名: ADE2; AIRC; PAIS; ADE2H1; PAICSD

关于 PAICS

功能概要

该基因编码一种双功能酶，其 N 末端区域含有磷酸核糖氨基咪唑羧化酶活性，C 末端区域含有磷酸核糖氨基咪唑琥珀酰甲酰胺合成酶。它催化嘌呤生物合成的第 6 步和第 7 步。该基因与在同一途径中编码酶的基因座紧密连锁和发散转录，并且这两个基因的转录受到协调调节。人类基因组包含该基因的几个假基因。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a bifunctional Enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an Enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]