MEAF6 - MYST/Esa1 associated factor 6 Gene

中文名称：MYST/Esa1 相关因子 6

种属: Homo sapiens

同用名: EAF6; CENP-28; C1orf149; NY-SAR-91

基因 ID: 64769 | 基因类型: protein coding

关于 MEAF6

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:37,489,993-37,514,766 (from NCBI)

This gene has 9 transcripts (splice variants) and 216 orthologues. Ubiquitous expression in prostate (RPKM 17.1), testis (RPKM 12.4) and 25 other tissues.

功能概要

该基因编码参与转录激活的核蛋白。编码的蛋白质可能形成几种不同的组蛋白乙酰转移酶复合物的组分。该基因在 2 号染色体上有一个假基因。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 8 月]

This gene encodes a nuclear protein involved in transcriptional activation. The encoded protein may form a component of several different Histone Acetyltransferase complexes. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

MEAF6 基因产物(3)

mRNA	Protein	Name
NM_001270875.3	NP_001257804.1	chromatin modification-related protein MEAF6 isoform 2
NM_001270876.3	NP_001257805.1	chromatin modification-related protein MEAF6 isoform 3
NM_022756.7	NP_073593.2	chromatin modification-related protein MEAF6 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
contributes to histone H3K14 acetyltransferase activity	IDA IDA: 通过直接分析推断	16387653	GOA
contributes to histone H4K12 acetyltransferase activity	IDA IDA: 通过直接分析推断	16387653	GOA
contributes to histone H4K5 acetyltransferase activity	IDA IDA: 通过直接分析推断	16387653	GOA
contributes to histone H4K8 acetyltransferase activity	IDA IDA: 通过直接分析推断	16387653	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of double-strand break repair via homologous recombination	IDA IDA: 通过直接分析推断	27153538	GOA
involved in regulation of DNA biosynthetic process	IDA IDA: 通过直接分析推断	16387653	GOA
involved in regulation of DNA replication	IDA IDA: 通过直接分析推断	16387653	GOA
involved in regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	18794358	GOA
involved in regulation of cell cycle	IDA IDA: 通过直接分析推断	16387653	GOA
involved in regulation of cell cycle	IMP IMP: 通过突变表型推断	27153538	GOA
involved in regulation of cell growth	IDA IDA: 通过直接分析推断	22144582	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of MOZ/MORF histone acetyltransferase complex	IDA IDA: 通过直接分析推断	16387653	GOA
part of NuA4 histone acetyltransferase complex	IDA IDA: 通过直接分析推断	14966270	GOA
part of histone acetyltransferase complex	IDA IDA: 通过直接分析推断	16387653	GOA
part of histone acetyltransferase complex	IPI IPI: 通过物理相互作用推断	16387653	GOA
located in kinetochore	IDA IDA: 通过直接分析推断	20813266	GOA
located in nucleolus	IDA IDA: 通过直接分析推断	18794358	GOA
located in nucleoplasm	IDA IDA: 通过直接分析推断	16387653	GOA
part of nucleosome	IDA IDA: 通过直接分析推断	27153538	GOA
located in nucleus	IDA IDA: 通过直接分析推断	18794358	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MEAF6 蛋白结构

NuA4

0
100
191 a.a.

蛋白主名

其他名称

chromatin modification-related protein MEAF6

Esa1p-associated factor 6 homolog

MEAF6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	MEAF6	Q9HAF1	JADE2	Homo sapiens	A0A0C4DFT8	Y2H Array	32296183
Intra	MEAF6	Q9HAF1	JADE2	Homo sapiens	A0A0C4DFT8	Y2H Prey Pooling	32296183
Intra	MEAF6	Q9HAF1	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	25416956
Intra	MEAF6	Q9HAF1	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
Intra	MEAF6	Q9HAF1	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	25416956
Intra	MEAF6	Q9HAF1	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	MEAF6	Q9HAF1	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	MEAF6	Q9HAF1	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	MEAF6	Q9HAF1	L3MBTL2	Homo sapiens	Q969R5	Y2H Pooling	16189514
Intra	MEAF6	Q9HAF1	L3MBTL2	Homo sapiens	Q969R5	Y2H Prey Pooling	32296183
Intra	MEAF6	Q9HAF1	L3MBTL2	Homo sapiens	Q969R5	Anti Tag CoIP	33961781
Intra	MEAF6	Q9HAF1	LDOC1	Homo sapiens	O95751	Y2H Prey Pooling	25416956
Intra	MEAF6	Q9HAF1	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	19060904
Intra	MEAF6	Q9HAF1	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	25416956
Intra	MEAF6	Q9HAF1	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	25416956
Intra	MEAF6	Q9HAF1	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Pooling	19060904

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Ossifying Fibromyxoid Tumor

Ossifying Fibromyxoid Tumour

Ossifying Fibromyxoma

Myxoid Leiomyosarcoma

Leiomyosarcoma, Myxoid

Ohdo Syndrome, Sbbys Variant

Say-Barber-Biesecker-Young-Simpson Syndrome	SBBYSS
Young-Simpson Syndrome	Blepharophimosis-Intellectual Disability Syndrome, Sbbys Type
Yss	Sbbys Variant Of Ohdo Syndrome
Blepharophimosis - Intellectual Disability Syndrome, Sbbys Type	Young Simpson Syndrome
Sbbyss Syndrome	Ohdo Syndrome, Say-Barber-Biesecker-Young-Simpson Variant
Blepharophimosis And Mental Retardation Syndrome, Say-Barber/Biesecker/Young-Simpson Type	Blepharophimosis-Intellectual Deficit Syndrome, Say-Barber/Biesecker/Young-Simpson Type
Bmrs Sbbys	Ohdo Syndrome, Say-Barber-Biesecker Variant
Say-Barber-Biesecker-Young-Simpson Variant Of Ohdo Syndrome	Hypothyroidism-Dysmorphism-Postaxial Polydactyly-Intellectual Disability Syndrome
Say-Barber-Biesecker Variant Of Ohdo Syndrome

Endometrial Stromal Tumor

Endometrial Stromal Neoplasm

Endometrial Stromal Tumors

Endometrial Stromal Nodule

Cellular Leiomyoma

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Atrophy Of Testis

Atrophic Testicle	Atrophy Of Testicle
Testicular Atrophy

Ohdo Syndrome

Young Simpson Syndrome	Ohdo Blepharophimosis Syndrome
Blepharophimosis Syndrome Ohdo Type	Blepharophimosis Intellectual Disability Syndromes
Bmrs	Blepharophimosis-Intellectual Disability Syndrome
Mental Retardation, Congenital Heart Disease, Blepharophimosis, Blepharoptosis, And Hypoplastic Teeth	Sbbys Syndrome
Say Barber Biesecker Young-Simpson Syndrome	Blepharophimosis-Intellectual Disability Syndrome, Ohdo Type
Bmrs, Ohdo Type	Blepharophimosis Syndrome, Ohdo Type
Ohdo-Madokoro-Sonoda Syndrome	Blepharophimosis - Intellectual Disability Syndrome, Ohdo Type
Blepharophimosis - Intellectual Disability Syndrome

Endometrial Stromal Sarcoma

Ess	Endometrial Stromal Sarcoma, High Grade
Undifferentiated Endometrial Sarcoma	Stromal Sarcoma Of The Corpus Uteri
Sarcoma Endometrial Stromal	Sarcoma, Endometrial Stromal
Undifferentiated Stromal Sarcoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08274	MEAF6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	MEAF6	VGNC	VGNC:31342
Macaca mulatta	MEAF6	VGNC	VGNC:74580
Canis familiaris	MEAF6	VGNC	VGNC:43113
Rattus norvegicus	MEAF6	RGD	RGD:1310440
Mus musculus	MEAF6	MGD	MGI:1917338
Felis catus	MEAF6	VGNC	VGNC:80278

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