PRAM1 - PML-RARA regulated adaptor molecule 1 Gene

中文名称：PML-RARA 调节接头分子 1

种属: Homo sapiens

同用名: PRAM-1; PML-RAR

基因 ID: 84106 | 基因类型: protein coding

关于 PRAM1

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,490,056-8,502,640 (from NCBI)

This gene has 4 transcripts (splice variants), 145 orthologues and 2 paralogues. Biased expression in bone marrow (RPKM 29.0), appendix (RPKM 3.8) and 2 other tissues.

功能概要

该基因编码的蛋白质类似于 Fyn 结合蛋白 (FYB/SLAP-130) ，这是一种参与 T 细胞受体介导的信号转导的衔接蛋白。该基因在正常骨髓细胞生成过程中表达和调节。该基因的表达由视黄酸诱导，并被 PML-RARalpha 的表达抑制，PML-RARalpha 是早幼粒细胞白血病 (PML) 和视黄酸受体-α (RARalpha) 的融合蛋白。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is similar to Fyn binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008]

PRAM1 基因产物(1)

mRNA	Protein	Name
NM_032152.5	NP_115528.4	PML-RARA-regulated adapter molecule 1

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	21163940	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	20873783	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of protein-containing complex	IDA IDA: 通过直接分析推断	20873783	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRAM1 蛋白结构

hSH3

0
200
400
600
670 a.a.

蛋白主名

其他名称

PML-RARA-regulated adapter molecule 1

PML-RARA target gene encoding an Adaptor Molecule-1

PRAM1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	PRAM1	Q96QH2	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	PRAM1	Q96QH2	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	PRAM1	Q96QH2	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	PRAM1	Q96QH2	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	PRAM1	Q96QH2	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	PRAM1	Q96QH2	CCDC57	Homo sapiens	Q2TAC2-2	Y2H Prey Pooling	32296183
Intra	PRAM1	Q96QH2	CCDC57	Homo sapiens	Q2TAC2-2	Y2H Array	32296183
Intra	PRAM1	Q96QH2	FXR1	Homo sapiens	P51114-2	Y2H Prey Pooling	32296183
Intra	PRAM1	Q96QH2	FXR1	Homo sapiens	P51114-2	Y2H Array	32296183
Intra	PRAM1	Q96QH2	NEDD9	Homo sapiens	Q14511-2	Y2H Array	32296183
Intra	PRAM1	Q96QH2	NEDD9	Homo sapiens	Q14511-2	Y2H Prey Pooling	32296183
Intra	PRAM1	Q96QH2	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
Intra	PRAM1	Q96QH2	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
Intra	PRAM1	Q96QH2	SKAP1	Homo sapiens	Q86WV1-2	Y2H Prey Pooling	32296183
Intra	PRAM1	Q96QH2	SKAP1	Homo sapiens	Q86WV1-2	Y2H Array	32296183
Intra	PRAM1	Q96QH2	SKAP1	Homo sapiens	Q86WV1	Y2H Array	31515488
Intra	PRAM1	Q96QH2	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	PRAM1	Q96QH2	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	PRAM1	Q96QH2	BCAR1	Homo sapiens	P56945	Y2H Prey Pooling	32296183
Intra	PRAM1	Q96QH2	BCAR1	Homo sapiens	P56945	Y2H Array	32296183
Intra	PRAM1	Q96QH2	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	PRAM1	Q96QH2	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	PRAM1	Q96QH2	RNF32	Homo sapiens	Q9H0A6	Y2H Array	21163940
Intra	PRAM1	Q96QH2	RNF32	Homo sapiens	Q9H0A6	Pull Down	21163940
Intra	PRAM1	Q96QH2	CDH1	Homo sapiens	P12830	Validated Y2H	32814053
Intra	PRAM1	Q96QH2	CDH1	Homo sapiens	P12830	Y2H Array	32814053
Intra	PRAM1	Q96QH2	CDH1	Homo sapiens	P12830	Y2H Pooling	32814053
Intra	PRAM1	Q96QH2	FXR2	Homo sapiens	P51116	Y2H Prey Pooling	32296183
Intra	PRAM1	Q96QH2	FXR2	Homo sapiens	P51116	Y2H Array	25416956
Intra	PRAM1	Q96QH2	FXR2	Homo sapiens	P51116	Y2H Array	32296183
Intra	PRAM1	Q96QH2	FXR2	Homo sapiens	P51116	Y2H Array	31515488

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11048	PRAM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	PRAM1	MGD	MGI:3576625
Canis familiaris	PRAM1	VGNC	VGNC:44940
Bos taurus	PRAM1	VGNC	VGNC:33284
Rattus norvegicus	PRAM1	RGD	RGD:1564330
Macaca mulatta	PRAM1	VGNC	VGNC:76344

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PRAM1 - PML-RARA regulated adaptor molecule 1 Gene

关于 PRAM1

功能概要

PRAM1 基因产物(1)

PRAM1 蛋白结构

PRAM1 蛋白互作信息

关联疾病

直系同源

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PRAM1 - PML-RARA regulated adaptor molecule 1 Gene

关于 PRAM1

功能概要

PRAM1 基因产物(1)

PRAM1 蛋白结构

PRAM1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z