SKAP1 - src kinase associated phosphoprotein 1 Gene

中文名称：src 激酶相关磷蛋白 1

种属: Homo sapiens

同用名: SCAP1; SKAP55; HEL-S-81p

关于 SKAP1

功能概要

该基因编码 T 细胞衔接蛋白，这是一类具有模块化结构域的细胞内分子，能够募集额外的蛋白质，但不表现出内在的酶活性。编码的蛋白质包含一个独特的 N 末端区域，后跟一个 PH 结构域和 C 末端 SH3 结构域。与粘附和脱颗粒促进衔接蛋白一起，编码的蛋白质通过将 T 细胞抗原受体刺激与整合素的激活相结合，在由内而外的信号传导中起着关键作用。[RefSeq 提供，2008 年 7 月]

This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]