2. Gene
  3. SH2D4A - SH2 domain containing 4A Gene

SH2D4A - SH2 domain containing 4A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：含 SH2 结构域 4A

种属: Homo sapiens

同用名: SH2A; PPP1R38

基因 ID: 63898 | 基因类型: protein coding

关于 SH2D4A

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:19,313,693-19,396,218 (from NCBI)

This gene has 6 transcripts (splice variants), 229 orthologues and 4 paralogues. Ubiquitous expression in ovary (RPKM 11.6), stomach (RPKM 9.2) and 22 other tissues.

功能概要

启用磷酸酶结合活性。位于胞质溶胶中。 [由基因组资源联盟提供，2022 年 4 月]

Enables Phosphatase binding activity. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

SH2D4A 基因产物(5)

mRNA Protein Name
NM_001174159.2 NP_001167630.1 SH2 domain-containing protein 4A isoform a
NM_001174160.2 NP_001167631.1 SH2 domain-containing protein 4A isoform b
NM_001363110.2 NP_001350039.1 SH2 domain-containing protein 4A isoform c
NM_001363111.2 NP_001350040.1 SH2 domain-containing protein 4A isoform c
NM_022071.4 NP_071354.2 SH2 domain-containing protein 4A isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatase binding IDA
IDA: 通过直接分析推断
19389623 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SH2D4A 蛋白结构

SH2

SH2: SH2 domain (347 - 423)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 454 a.a.
蛋白主名 其他名称

SH2 domain-containing protein 4A

protein SH(2)A

SH2D4A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SH2D4A Q9H788 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra SH2D4A Q9H788 NECAB2 Homo sapiens Q7Z6G3-2
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 NECAB2 Homo sapiens Q7Z6G3-2
Y2H Array
32296183
Intra SH2D4A Q9H788 NECAB2 Homo sapiens Q7Z6G3-2
Validated Y2H
25416956
Intra SH2D4A Q9H788 SH3GL1 Homo sapiens Q6FGM0
Y2H Array
25416956
Intra SH2D4A Q9H788 NUTM1 Homo sapiens Q86Y26
Y2H Prey Pooling
25416956
Intra SH2D4A Q9H788 NUTM1 Homo sapiens Q86Y26
Y2H Array
25416956
Intra SH2D4A Q9H788 CADPS Homo sapiens A2RRN7
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 CADPS Homo sapiens A2RRN7
Y2H Array
32296183
Intra SH2D4A Q9H788 ZNF774 Homo sapiens Q6NX45
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 ZNF774 Homo sapiens Q6NX45
Y2H Array
32296183
Intra SH2D4A Q9H788 MAGEA6 Homo sapiens P43360
Y2H Prey Pooling
25416956
Intra SH2D4A Q9H788 MAGEA6 Homo sapiens P43360
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 MAGEA6 Homo sapiens P43360
Y2H Array
32296183
Intra SH2D4A Q9H788 PSTPIP1 Homo sapiens O43586
Validated Y2H
25416956
Intra SH2D4A Q9H788 PSTPIP1 Homo sapiens O43586
Y2H Array
25416956
Intra SH2D4A Q9H788 HOOK2 Homo sapiens Q96ED9-2
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 HOOK2 Homo sapiens Q96ED9-2
Y2H Array
32296183
Intra SH2D4A Q9H788 GRAMD4 Homo sapiens Q6IC98
Y2H Array
32296183
Intra SH2D4A Q9H788 GRAMD4 Homo sapiens Q6IC98
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 PDE4DIP Homo sapiens Q5VU43
Y2H Prey Pooling
25416956
Intra SH2D4A Q9H788 PDE4DIP Homo sapiens Q5VU43
Validated Y2H
25416956
Intra SH2D4A Q9H788 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra SH2D4A Q9H788 TFIP11 Homo sapiens Q9UBB9
Y2H Array
31515488
Intra SH2D4A Q9H788 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra SH2D4A Q9H788 TRIML2 Homo sapiens Q8N7C3
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 TRIML2 Homo sapiens Q8N7C3
Y2H Array
32296183
Intra SH2D4A Q9H788 CDR2L Homo sapiens Q86X02
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 CDR2L Homo sapiens Q86X02
Y2H Array
32296183
Intra SH2D4A Q9H788 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra SH2D4A Q9H788 CDR2 Homo sapiens Q01850
Y2H Array
32296183
Intra SH2D4A Q9H788 CDR2 Homo sapiens Q01850
Validated Y2H
25416956
Intra SH2D4A Q9H788 CDR2 Homo sapiens Q01850
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 FCHSD2 Homo sapiens O94868-3
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 FCHSD2 Homo sapiens O94868-3
Y2H Array
32296183
Intra SH2D4A Q9H788 FCHO1 Homo sapiens A0A0C3SFZ9
Y2H Array
32296183
Intra SH2D4A Q9H788 FCHO1 Homo sapiens A0A0C3SFZ9
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 CASK Homo sapiens O14936-4
Y2H Array
32296183
Intra SH2D4A Q9H788 CASK Homo sapiens O14936-4
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 TACC1 Homo sapiens O75410-7
Y2H Array
32296183
Intra SH2D4A Q9H788 TACC1 Homo sapiens O75410-7
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra SH2D4A Q9H788 WWOX Homo sapiens Q9NZC7-5
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
Intra SH2D4A Q9H788 WWOX Homo sapiens Q9NZC7-5
Y2H Array
32296183
Intra SH2D4A Q9H788 CASK Homo sapiens O14936
Y2H Array
29892012
Intra SH2D4A Q9H788 CASK Homo sapiens O14936
Y2H Prey Pooling
25416956
Intra SH2D4A Q9H788 DBNL Homo sapiens Q9UJU6-2
Validated Y2H
32296183
Intra SH2D4A Q9H788 DBNL Homo sapiens Q9UJU6-2
Y2H Array
32296183
Intra SH2D4A Q9H788 DBNL Homo sapiens Q9UJU6-2
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 MBD3L1 Homo sapiens Q8WWY6
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 MBD3L1 Homo sapiens Q8WWY6
Y2H Array
32296183
Intra SH2D4A Q9H788 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra SH2D4A Q9H788 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 SKAP1 Homo sapiens Q86WV1
Y2H Prey Pooling
25416956
Intra SH2D4A Q9H788 SKAP1 Homo sapiens Q86WV1
Validated Y2H
25416956
Intra SH2D4A Q9H788 CCDC172 Homo sapiens P0C7W6
Y2H Prey Pooling
25416956
Intra SH2D4A Q9H788 CCDC172 Homo sapiens P0C7W6
Y2H Array
25416956
Intra SH2D4A Q9H788 HMBOX1 Homo sapiens Q6NT76
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 HMBOX1 Homo sapiens Q6NT76
Y2H Array
32296183
Intra SH2D4A Q9H788 HMBOX1 Homo sapiens Q6NT76
Y2H Prey Pooling
25416956
Intra SH2D4A Q9H788 VPS52 Homo sapiens Q8N1B4
Y2H Array
25416956
Intra SH2D4A Q9H788 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
25416956
Intra SH2D4A Q9H788 PRKAR1B Homo sapiens P31321
Y2H Array
32296183
Intra SH2D4A Q9H788 PRKAR1B Homo sapiens P31321
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 PNMA1 Homo sapiens Q8ND90
Y2H Array
32296183
Intra SH2D4A Q9H788 CCDC88B Homo sapiens A6NC98
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 CCDC88B Homo sapiens A6NC98
Y2H Array
32296183
Intra SH2D4A Q9H788 PPP1CB Homo sapiens P62140
Validated Y2H
25416956
Intra SH2D4A Q9H788 PPP1CB Homo sapiens P62140
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 PPP1CB Homo sapiens P62140
Y2H Prey Pooling
25416956
Intra SH2D4A Q9H788 PPP1CB Homo sapiens P62140
Y2H Array
25416956
Intra SH2D4A Q9H788 PPP1CB Homo sapiens P62140
Y2H Array
32296183
Intra SH2D4A Q9H788 PPP1CB Homo sapiens P62140
Anti Tag CoIP
33961781
Intra SH2D4A Q9H788 PPP1CB Homo sapiens P62140
Anti Tag CoIP
28514442
Intra SH2D4A Q9H788 PPP1CA Homo sapiens P62136
Anti Tag CoIP
28514442
Intra SH2D4A Q9H788 PPP1CA Homo sapiens P62136
Far-WB
19389623
Intra SH2D4A Q9H788 PPP1CA Homo sapiens P62136
Anti Tag CoIP
33961781
Intra SH2D4A Q9H788 STAM2 Homo sapiens O75886
Validated Y2H
25416956
Intra SH2D4A Q9H788 ALAS1 Homo sapiens P13196
Y2H Array
25416956
Intra SH2D4A Q9H788 ALAS1 Homo sapiens P13196
Y2H Prey Pooling
25416956
Intra SH2D4A Q9H788 GRB2 Homo sapiens P62993
Y2H Pooling
20936779
Intra SH2D4A Q9H788 GRB2 Homo sapiens P62993
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 GRB2 Homo sapiens P62993
Y2H Array
32296183
Intra SH2D4A Q9H788 SPAG5 Homo sapiens Q96R06
Validated Y2H
25416956
Intra SH2D4A Q9H788 BLOC1S2 Homo sapiens Q6QNY1
Y2H Array
32296183
Intra SH2D4A Q9H788 BLOC1S2 Homo sapiens Q6QNY1
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 GPRASP2 Homo sapiens Q96D09
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 GPRASP2 Homo sapiens Q96D09
Y2H Array
32296183
Intra SH2D4A Q9H788 FSD2 Homo sapiens A1L4K1
Y2H Array
32296183
Intra SH2D4A Q9H788 FSD2 Homo sapiens A1L4K1
Y2H Prey Pooling
25416956
Intra SH2D4A Q9H788 FSD2 Homo sapiens A1L4K1
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra SH2D4A Q9H788 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra SH2D4A Q9H788 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra SH2D4A Q9H788 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra SH2D4A Q9H788 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra SH2D4A Q9H788 YPEL2 Homo sapiens Q96QA6
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 YPEL2 Homo sapiens Q96QA6
Y2H Array
32296183
Intra SH2D4A Q9H788 SH3GL1 Homo sapiens Q99961
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 SH3GL1 Homo sapiens Q99961
Y2H Array
19060904
Intra SH2D4A Q9H788 SH3GL1 Homo sapiens Q99961
Y2H Pooling
19060904
Intra SH2D4A Q9H788 SH3GL1 Homo sapiens Q99961
Y2H Array
32296183
Intra SH2D4A Q9H788 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra SH2D4A Q9H788 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra SH2D4A Q9H788 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra SH2D4A Q9H788 NINL Homo sapiens Q9Y2I6
Y2H Array
25416956
Intra SH2D4A Q9H788 NINL Homo sapiens Q9Y2I6
Y2H Prey Pooling
25416956
Intra SH2D4A Q9H788 RINT1 Homo sapiens Q6NUQ1
Validated Y2H
25416956
Intra SH2D4A Q9H788 RINT1 Homo sapiens Q6NUQ1
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 RINT1 Homo sapiens Q6NUQ1
Y2H Array
32296183
Intra SH2D4A Q9H788 MAGEA11 Homo sapiens P43364
Pull Down
16189514
Intra SH2D4A Q9H788 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 TRIM23 Homo sapiens P36406
Y2H Array
25416956
Intra SH2D4A Q9H788 GRAP2 Homo sapiens O75791
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 GRAP2 Homo sapiens O75791
Y2H Array
32296183
Intra SH2D4A Q9H788 LDOC1 Homo sapiens O95751
Y2H Array
31515488
Intra SH2D4A Q9H788 LDOC1 Homo sapiens O95751
Y2H Prey Pooling
25416956
Intra SH2D4A Q9H788 LDOC1 Homo sapiens O95751
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 LDOC1 Homo sapiens O95751
Y2H Array
32296183
Intra SH2D4A Q9H788 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
Intra SH2D4A Q9H788 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra SH2D4A Q9H788 CFAP53 Homo sapiens Q96M91
Y2H Array
32296183
Intra SH2D4A Q9H788 CFAP53 Homo sapiens Q96M91
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 IKZF1 Homo sapiens Q13422
Y2H Array
25416956
Intra SH2D4A Q9H788 IKZF1 Homo sapiens Q13422
Y2H Prey Pooling
25416956
Intra SH2D4A Q9H788 IKZF1 Homo sapiens Q13422
Validated Y2H
25416956
Intra SH2D4A Q9H788 HCLS1 Homo sapiens P14317
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 HCLS1 Homo sapiens P14317
Y2H Array
32296183
Intra SH2D4A Q9H788 HCLS1 Homo sapiens P14317
Y2H Array
25416956
Intra SH2D4A Q9H788 HCLS1 Homo sapiens P14317
Y2H Array
31515488
Intra SH2D4A Q9H788 ARC Homo sapiens Q7LC44
Y2H Array
32296183
Intra SH2D4A Q9H788 ARC Homo sapiens Q7LC44
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 DBNL Homo sapiens Q9UJU6
Y2H Array
25416956
Intra SH2D4A Q9H788 DBNL Homo sapiens Q9UJU6
Y2H Array
19060904
Intra SH2D4A Q9H788 DBNL Homo sapiens Q9UJU6
Y2H Prey Pooling
25416956
Intra SH2D4A Q9H788 DBNL Homo sapiens Q9UJU6
Y2H Pooling
19060904
Intra SH2D4A Q9H788 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra SH2D4A Q9H788 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra SH2D4A Q9H788 TTC19 Homo sapiens Q6DKK2
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 TTC19 Homo sapiens Q6DKK2
Y2H Array
32296183
Intra SH2D4A Q9H788 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
Intra SH2D4A Q9H788 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 MORN3 Homo sapiens Q6PF18
Y2H Prey Pooling
32296183
Intra SH2D4A Q9H788 MORN3 Homo sapiens Q6PF18
Y2H Array
32296183
Intra SH2D4A Q9H788 MRFAP1 Homo sapiens Q9Y605
Validated Y2H
32296183
Intra SH2D4A Q9H788 MRFAP1 Homo sapiens Q9Y605
Y2H Array
32296183
Intra SH2D4A Q9H788 MRFAP1 Homo sapiens Q9Y605
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12825 SH2D4A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SH2D4A VGNC VGNC:46114
Macaca mulatta SH2D4A VGNC VGNC:81568
Bos taurus SH2D4A VGNC VGNC:34560
Mus musculus SH2D4A MGD MGI:1919531
Rattus norvegicus SH2D4A RGD RGD:1307991
Felis catus SH2D4A VGNC VGNC:65095
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