CCDC88B - coiled-coil domain containing 88B Gene

中文名称：含卷曲螺旋结构域 88B

种属: Homo sapiens

同用名: BRLZ; HKRP3; gipie; CCDC88

基因 ID: 283234 | 基因类型: protein coding

关于 CCDC88B

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,340,204-64,357,534 (from NCBI)

This gene has 10 transcripts (splice variants), 181 orthologues and 5 paralogues. Biased expression in bone marrow (RPKM 19.8), spleen (RPKM 16.5) and 13 other tissues.

功能概要

该基因编码钩相关蛋白家族的一个成员。该家族成员的特征在于 N 端潜在微管结合域、中央卷曲-卷曲和 C 端 Hook 相关域。编码的蛋白质可能参与连接细胞器和微管。[RefSeq 提供，2009 年 10 月]

This gene encodes a member of the hook-related protein family. Members of this family are characterized by an N-terminal potential microtubule binding domain, a central coiled-coiled and a C-terminal Hook-related domain. The encoded protein may be involved in linking organelles to microtubules. [provided by RefSeq, Oct 2009]

CCDC88B 基因产物(1)

mRNA	Protein	Name
NM_032251.6	NP_115627.6	coiled-coil domain-containing protein 88B precursor

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCDC88B 蛋白结构

HOOK

0
300
600
900
1200
1476 a.a.

蛋白主名

其他名称

coiled-coil domain-containing protein 88B

78 kDa glucose-regulated protein [GRP78]-interacting protein induced by ER stress

CCDC88B 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CCDC88B	A6NC98	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	TSGA10IP	Homo sapiens	Q3SY00	Y2H Prey Pooling	32296183
种属内	CCDC88B	A6NC98	TSGA10IP	Homo sapiens	Q3SY00	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	TSHZ2	Homo sapiens	Q9NRE2	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	CARD9	Homo sapiens	Q9H257-2	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	DTNB	Homo sapiens	O60941-5	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	ZC2HC1C	Homo sapiens	Q53FD0-2	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	PPP1R18	Homo sapiens	Q6NYC8	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	LMNB2	Homo sapiens	Q03252	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	SH3KBP1	Homo sapiens	Q96B97	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	TSG101	Homo sapiens	Q99816	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	EXOSC5	Homo sapiens	Q9NQT4	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	HOXB5	Homo sapiens	P09067	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	CWF19L2	Homo sapiens	Q2TBE0	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	TXLNB	Homo sapiens	Q8N3L3	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	PIN1	Homo sapiens	Q13526	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	FAM161A	Homo sapiens	Q3B820	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	FAM161B	Homo sapiens	Q96MY7	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	RINT1	Homo sapiens	Q6NUQ1	Y2H Prey Pooling	32296183
种属内	CCDC88B	A6NC98	RINT1	Homo sapiens	Q6NUQ1	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	RINT1	Homo sapiens	Q6NUQ1	Y2H Array	32296183
种属内	CCDC88B	A6NC98	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	USP2	Homo sapiens	O75604	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	GEM	Homo sapiens	P55040	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	TSGA10	Homo sapiens	Q9BZW7	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	BEX2	Homo sapiens	Q9BXY8	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	DEF6	Homo sapiens	Q9H4E7	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	CDK18	Homo sapiens	Q07002	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	RBM7	Homo sapiens	Q9Y580	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	SH2D4A	Homo sapiens	Q9H788	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	RALBP1	Homo sapiens	Q15311	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	JAKMIP2	Homo sapiens	Q96AA8	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	TRAF3IP3	Homo sapiens	Q9Y228	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	LMO1	Homo sapiens	P25800	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	TBC1D22B	Homo sapiens	Q9NU19	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	LMNB1	Homo sapiens	P20700	Validated Y2H	32296183
种属内	CCDC88B	A6NC98	HCK	Homo sapiens	P08631-2	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Leprosy 3

Leprosy	Leprosy, Susceptibility To, 3
Hansen'S Disease	Leprosy, Susceptibility To
Hansen Disease	Infection Due To Mycobacterium Leprae
LPRS3	Leprosy, Type 3
Anaesthesia Leprosy	Anaesthetic Leprosy
Maculoanaesthetic Leprosy	Macular Leprosy
Leprosy Unspecified

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02062	CCDC88B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	CCDC88B	VGNC	VGNC:38868
Rattus norvegicus	CCDC88B	RGD	RGD:1311475
Macaca mulatta	CCDC88B	VGNC	VGNC:100902
Felis catus	CCDC88B	VGNC	VGNC:60523
Bos taurus	CCDC88B	VGNC	VGNC:26928
Mus musculus	CCDC88B	MGD	MGI:1925567

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