2. Gene
  3. EXOSC5 - exosome component 5 Gene

EXOSC5 - exosome component 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：外泌体组分 5

种属: Homo sapiens

同用名: p12B; CABAC; RRP46; RRP41B; Rrp46p; hRrp46p

基因 ID: 56915 | 基因类型: protein coding

关于 EXOSC5

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:41,386,374-41,397,359 (from NCBI)

This gene has 6 transcripts (splice variants), 187 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 8.8), ovary (RPKM 8.2) and 25 other tissues.

功能概要

预测启用 RNA 结合活性。参与脱腺苷酸化 mRNA 的 DNA 脱氨和核酸外切分解代谢。作用于对病毒的防御反应上游或内部。位于核仁；核质；和转录活性染色质。外泌体的一部分 (RNase 复合物) 。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable RNA binding activity. Involved in DNA deamination and exonucleolytic catabolism of deadenylated mRNA. Acts upstream of or within defense response to virus. Located in nucleolus; nucleoplasm; and transcriptionally active chromatin. Part of exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]

EXOSC5 基因产物(1)

mRNA Protein Name
NM_020158.4 NP_064543.3 exosome complex component RRP46
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables RNA exonuclease activity IDA
IDA: 通过直接分析推断
17174896 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11812149 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA deamination IDA
IDA: 通过直接分析推断
21255825 GOA
involved in RNA catabolic process IDA
IDA: 通过直接分析推断
17174896 GOA
involved in RNA processing IDA
IDA: 通过直接分析推断
17174896 GOA
acts upstream of or within defense response to virus IMP
IMP: 通过突变表型推断
21791617 GOA
involved in mRNA catabolic process IMP
IMP: 通过突变表型推断
11782436 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
20531386 GOA
located in euchromatin IMP
IMP: 通过突变表型推断
20699273 GOA
part of exosome (RNase complex) IDA
IDA: 通过直接分析推断
20531389 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
20531386 GOA
located in nucleus IDA
IDA: 通过直接分析推断
20531386 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EXOSC5 蛋白结构

RNase_PH

RNase_PH: 3' exoribonuclease family, domain 1 (28 - 147)

RNase_PH_C

RNase_PH_C: 3' exoribonuclease family, domain 2 (151 - 215)

  • 0
  • 100
  • 200
  • 235 a.a.
蛋白主名 其他名称

exosome complex component RRP46

chronic myelogenous leukemia tumor antigen 28

EXOSC5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra EXOSC5 Q9NQT4 KRT13 Homo sapiens A1A4E9
Validated Y2H
25416956
Intra EXOSC5 Q9NQT4 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 DOCK8 Homo sapiens Q8NF50-2
Y2H Prey Pooling
25416956
Intra EXOSC5 Q9NQT4 DOCK8 Homo sapiens Q8NF50-2
Validated Y2H
25416956
Intra EXOSC5 Q9NQT4 DOCK8 Homo sapiens Q8NF50-2
Y2H Array
25416956
Intra EXOSC5 Q9NQT4 BORCS6 Homo sapiens Q96GS4
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 BORCS6 Homo sapiens Q96GS4
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 PIH1D2 Homo sapiens Q8WWB5
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 PIH1D2 Homo sapiens Q8WWB5
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 ZNF792 Homo sapiens Q3KQV3
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 ZNF792 Homo sapiens Q3KQV3
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 FH Homo sapiens P07954
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 FH Homo sapiens P07954
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra EXOSC5 Q9NQT4 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 PRDM6 Homo sapiens Q9NQX0
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 PRDM6 Homo sapiens Q9NQX0
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 PRDM6 Homo sapiens Q9NQX0
Validated Y2H
32296183
Intra EXOSC5 Q9NQT4 ZFP90 Homo sapiens Q8TF47
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 ZFP90 Homo sapiens Q8TF47
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 FCHO1 Homo sapiens A0A0C3SFZ9
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 FCHO1 Homo sapiens A0A0C3SFZ9
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 SHISA6 Homo sapiens Q6ZSJ9
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 SHISA6 Homo sapiens Q6ZSJ9
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 ACOT11 Homo sapiens Q8WXI4-2
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 ACOT11 Homo sapiens Q8WXI4-2
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 LRMDA Homo sapiens A0A087WWI0
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 LRMDA Homo sapiens A0A087WWI0
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 EFHC2 Homo sapiens Q5JST6
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 TNFAIP1 Homo sapiens Q13829
Validated Y2H
25416956
Intra EXOSC5 Q9NQT4 TNFAIP1 Homo sapiens Q13829
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 TNFAIP1 Homo sapiens Q13829
Y2H Array
25416956
Intra EXOSC5 Q9NQT4 TNFAIP1 Homo sapiens Q13829
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 TNFAIP1 Homo sapiens Q13829
Y2H Prey Pooling
25416956
Intra EXOSC5 Q9NQT4 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 REL Homo sapiens Q04864
Validated Y2H
25416956
Intra EXOSC5 Q9NQT4 CCDC88B Homo sapiens A6NC98
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 CCDC88B Homo sapiens A6NC98
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 EXOSC10 Homo sapiens Q01780
TAP
24981860
Intra EXOSC5 Q9NQT4 EXOSC10 Homo sapiens Q01780
Anti Tag CoIP
26496610
Intra EXOSC5 Q9NQT4 EXOSC10 Homo sapiens Q01780
Anti Tag CoIP
21255825
Intra EXOSC5 Q9NQT4 EXOSC10 Homo sapiens Q01780
Anti Tag CoIP
33961781
Intra EXOSC5 Q9NQT4 EXOSC10 Homo sapiens Q01780
Y2H
15231747
Intra EXOSC5 Q9NQT4 EXOSC3 Homo sapiens Q9NQT5
Y2H
12419256
Intra EXOSC5 Q9NQT4 EXOSC3 Homo sapiens Q9NQT5
Anti Tag CoIP
21255825
Intra EXOSC5 Q9NQT4 EXOSC3 Homo sapiens Q9NQT5
TAP
24981860
Intra EXOSC5 Q9NQT4 EXOSC3 Homo sapiens Q9NQT5
Y2H
15231747
Intra EXOSC5 Q9NQT4 EXOSC3 Homo sapiens Q9NQT5
Anti Tag CoIP
33961781
Intra EXOSC5 Q9NQT4 EXOSC3 Homo sapiens Q9NQT5
Anti Tag CoIP
26496610
Intra EXOSC5 Q9NQT4 EXOSC1 Homo sapiens Q9Y3B2
Y2H
12419256
Intra EXOSC5 Q9NQT4 EXOSC1 Homo sapiens Q9Y3B2
Y2H Array
19060904
Intra EXOSC5 Q9NQT4 EXOSC1 Homo sapiens Q9Y3B2
Y2H
11812149
Intra EXOSC5 Q9NQT4 EXOSC1 Homo sapiens Q9Y3B2
Y2H
15231747
Intra EXOSC5 Q9NQT4 EXOSC8 Homo sapiens Q96B26
Anti Tag CoIP
26496610
Intra EXOSC5 Q9NQT4 EXOSC8 Homo sapiens Q96B26
Y2H Array
25416956
Intra EXOSC5 Q9NQT4 EXOSC8 Homo sapiens Q96B26
Y2H
12419256
Intra EXOSC5 Q9NQT4 EXOSC8 Homo sapiens Q96B26
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 EXOSC8 Homo sapiens Q96B26
Anti Tag CoIP
33961781
Intra EXOSC5 Q9NQT4 EXOSC8 Homo sapiens Q96B26
Y2H
15231747
Intra EXOSC5 Q9NQT4 EXOSC8 Homo sapiens Q96B26
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 EXOSC8 Homo sapiens Q96B26
Y2H Array
31515488
Intra EXOSC5 Q9NQT4 EXOSC8 Homo sapiens Q96B26
TAP
24981860
Intra EXOSC5 Q9NQT4 MTMR3 Homo sapiens Q13615
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 MTMR3 Homo sapiens Q13615
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 SPTA1 Homo sapiens P02549
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 SPTA1 Homo sapiens P02549
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 NKAPD1 Homo sapiens Q6ZUT1
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 NKAPD1 Homo sapiens Q6ZUT1
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 HOXC4 Homo sapiens P09017
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 HOXC4 Homo sapiens P09017
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 ZNF420 Homo sapiens Q8TAQ5
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 ZNF420 Homo sapiens Q8TAQ5
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 TRIB3 Homo sapiens Q96RU7
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 TRIB3 Homo sapiens Q96RU7
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 BIRC2 Homo sapiens Q13490
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 BIRC2 Homo sapiens Q13490
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra EXOSC5 Q9NQT4 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 PEG10 Homo sapiens Q86TG7-2
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 PEG10 Homo sapiens Q86TG7-2
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 SNW1 Homo sapiens Q13573
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 SNW1 Homo sapiens Q13573
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 TRIM62 Homo sapiens Q9BVG3
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 TRIM62 Homo sapiens Q9BVG3
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 MYLIP Homo sapiens Q8WY64
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 MYLIP Homo sapiens Q8WY64
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 FCHO1 Homo sapiens O14526
Y2H Array
31515488
Intra EXOSC5 Q9NQT4 CALCOCO2 Homo sapiens Q13137
Y2H Array
25416956
Intra EXOSC5 Q9NQT4 CALCOCO2 Homo sapiens Q13137
Validated Y2H
25416956
Intra EXOSC5 Q9NQT4 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 KCTD13 Homo sapiens Q8WZ19
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 KCTD13 Homo sapiens Q8WZ19
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 IKZF3 Homo sapiens Q9UKT9
Y2H Array
31515488
Intra EXOSC5 Q9NQT4 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
25416956
Intra EXOSC5 Q9NQT4 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
Intra EXOSC5 Q9NQT4 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra EXOSC5 Q9NQT4 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 LCA5L Homo sapiens O95447
Y2H Array
32296183
Intra EXOSC5 Q9NQT4 LCA5L Homo sapiens O95447
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra EXOSC5 Q9NQT4 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Cross EXOSC5 Q9NQT4 Zc3hav1 Rattus norvegicus Q8K3Y6
Anti Bait CoIP
22407013
Cross EXOSC5 Q9NQT4 Zc3hav1 Rattus norvegicus Q8K3Y6
Pull Down
17185417
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cerebellar Ataxia, Brain Abnormalities, And Cardiac Conduction Defects

CABAC
Cerebellar Hypoplasia
Pontocerebellar Hypoplasia, Type 1c

PCH1C

Hypomyelination With Spinal Muscular Atrophy And Cerebellar Hypoplasia

Pontocerebellar Hypoplasia Type 1c

Pontocerebellar Hypoplasia 1c

Doid:0112334

Hypoplasia, Pontocerebellar, Type 1c
Cat-Scratch Disease

Cat Scratch Disease

Benign Lymphoreticulosis

Cat Scratch Fever

Debre'S Syndrome

Bartonellosis Due To Bartonella Henselae Infection

Debre-Mollaret Syndrome

Foshay-Mollaret Cat Scratch Fever

Oroya Fever

Cat-Scratch Fever

Benign Inoculation Lymphoreticulosis

Catscratch Disease Or Fever

Csd - [Cat Scratch Disease]

Nonbacterial Regional Lymphadenitis

Rochalimaea Henselae Infection
Pontocerebellar Hypoplasia, Type 1b

Pontocerebellar Hypoplasia Type 1b

PCH1B

Pontocerebellar Hypoplasia 1b

Hypoplasia, Pontocerebellar, Type 1b
Trichohepatoenteric Syndrome 1

Trichohepatoenteric Syndrome

Syndromic Diarrhea

Tricho-Hepato-Enteric Syndrome

Sd/The

Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome

THES1

Phenotypic Diarrhea

Thes

Phenotypic Diarrhea Of Infancy

Diarrhea, Syndromic

Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa

Intractable Diarrhea With Phenotypic Anomalies

Syndromatic Diarrhea

Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Pontocerebellar Hypoplasia, Type 1e

Pontocerebellar Hypoplasia Type 1

PCH1E

Norman Disease

Pch1

Pontocerebellar Hypoplasia With Anterior Horn Cell Disease

Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy

Pontocerebellar Hypoplasia Type 1e

Pontocerebellar Hypoplasia 1e

Doid:0112322

Doid:0112330
Bartonellosis

Bartonella Infections

Bartonella Infectious Disease

Bartonelliasis

Rochalimaea Infection

Bartonellosis, Unspecified
Pontocerebellar Hypoplasia

Pch

Congenital Pontocerebellar Hypoplasia

Opch

Hypoplasia, Pontocerebellar

Pontoneocerebellar Hypoplasia

Nonsyndromic Pontocerebellar Hypoplasia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04601 EXOSC5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus EXOSC5 VGNC VGNC:28660
Rattus norvegicus EXOSC5 RGD RGD:1307861
Canis familiaris EXOSC5 VGNC VGNC:40526
Macaca mulatta EXOSC5 VGNC VGNC:72331
Mus musculus EXOSC5 MGD MGI:107889
Others EXOSC5 NCBI
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