HOXC4 - homeobox C4 Gene

中文名称：同源框 C4

种属: Homo sapiens

同用名: HOX3; cp19; HOX3E

基因 ID: 3221 | 基因类型: protein coding

关于 HOXC4

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:54,016,888-54,056,030 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues and 42 paralogues. Broad expression in kidney (RPKM 4.9), ovary (RPKM 2.4) and 16 other tissues.

功能概要

该基因属于同源盒基因家族。同源框基因编码一个高度保守的转录因子家族，在所有多细胞生物的形态发生中起着重要作用。哺乳动物拥有 4 个相似的同源盒基因簇 HOXA、HOXB、HOXC 和 HOXD，它们分别位于不同的染色体上，由 9～11 个串联排列的基因组成。该基因 HOXC4 是位于 12 号染色体簇中的几个同源框 HOXC 基因之一。三个基因 HOXC5、HOXC4 和 HOXC6 共享一个 5' 非编码外显子。转录本可能包括与基因特异性外显子剪接的共享外显子，或者它们可能仅包括基因特异性外显子。已经为 HOXC4 描述了编码相同蛋白质的两种可变剪接变体。转录变体一包括共享外显子，转录变体二仅包括基因特异性外显子。[RefSeq 提供，2008 年 7 月]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons. [provided by RefSeq, Jul 2008]

HOXC4 基因产物(2)

mRNA	Protein	Name
NM_014620.6	NP_055435.2	homeobox protein Hox-C4
NM_153633.3	NP_705897.1	homeobox protein Hox-C4

HOXC4 蛋白结构

Homeobox

0
100
200
264 a.a.

蛋白主名

其他名称

homeobox protein Hox-C4

homeo box 3E

HOXC4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HOXC4	P09017	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
种属内	HOXC4	P09017	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
种属内	HOXC4	P09017	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
种属内	HOXC4	P09017	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
种属内	HOXC4	P09017	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
种属内	HOXC4	P09017	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
种属内	HOXC4	P09017	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
种属内	HOXC4	P09017	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
种属内	HOXC4	P09017	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
种属内	HOXC4	P09017	GDAP1	Homo sapiens	Q8TB36	Validated Y2H	32814053
种属内	HOXC4	P09017	GDAP1	Homo sapiens	Q8TB36	Y2H Array	32814053
种属内	HOXC4	P09017	GDAP1	Homo sapiens	Q8TB36	Y2H Pooling	32814053
种属内	HOXC4	P09017	LMO3	Homo sapiens	Q8TAP4-4	Y2H Array	32814053
种属内	HOXC4	P09017	LMO3	Homo sapiens	Q8TAP4-4	Y2H Pooling	32814053
种属内	HOXC4	P09017	LMO3	Homo sapiens	Q8TAP4-4	Validated Y2H	32814053
种属内	HOXC4	P09017	TSC1	Homo sapiens	Q86WV8	Y2H Array	32814053
种属内	HOXC4	P09017	TSC1	Homo sapiens	Q86WV8	Validated Y2H	32814053
种属内	HOXC4	P09017	TSC1	Homo sapiens	Q86WV8	Y2H Pooling	32814053
种属内	HOXC4	P09017	CSNK2A1	Homo sapiens	P68400	Validated Y2H	32296183
种属内	HOXC4	P09017	SUV39H1	Homo sapiens	O43463	Anti Tag CoIP	23455924
种属内	HOXC4	P09017	SUV39H1	Homo sapiens	O43463	Y2H	23455924
种属内	HOXC4	P09017	PPIB	Homo sapiens	P23284	Validated Y2H	32814053
种属内	HOXC4	P09017	PPIB	Homo sapiens	P23284	Y2H Pooling	32814053
种属内	HOXC4	P09017	PPIB	Homo sapiens	P23284	Y2H Array	32814053
种属内	HOXC4	P09017	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
种属内	HOXC4	P09017	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
种属内	HOXC4	P09017	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
种属内	HOXC4	P09017	EXOSC5	Homo sapiens	Q9NQT4	Validated Y2H	32296183
种属内	HOXC4	P09017	SMN1	Homo sapiens	Q16637	Validated Y2H	32814053
种属内	HOXC4	P09017	SMN1	Homo sapiens	Q16637	Y2H Pooling	32814053
种属内	HOXC4	P09017	SMN1	Homo sapiens	Q16637	Y2H Array	32814053
种属内	HOXC4	P09017	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
种属内	HOXC4	P09017	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
种属内	HOXC4	P09017	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
种属内	HOXC4	P09017	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
种属内	HOXC4	P09017	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
种属内	HOXC4	P09017	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
种属内	HOXC4	P09017	HTT	Homo sapiens	P42858	Validated Y2H	32814053
种属内	HOXC4	P09017	HTT	Homo sapiens	P42858	Y2H Array	32814053
种属内	HOXC4	P09017	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
种属内	HOXC4	P09017	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
种属内	HOXC4	P09017	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
种属内	HOXC4	P09017	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
种属内	HOXC4	P09017	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
种属内	HOXC4	P09017	A2M	Homo sapiens	P01023	Validated Y2H	32814053
种属内	HOXC4	P09017	A2M	Homo sapiens	P01023	Y2H Array	32814053
种属内	HOXC4	P09017	CLK3	Homo sapiens	P49761	Y2H Array	32296183
种属内	HOXC4	P09017	CLK3	Homo sapiens	P49761	Y2H Prey Pooling	32296183
种属内	HOXC4	P09017	CLK3	Homo sapiens	P49761	Validated Y2H	32296183
种属内	HOXC4	P09017	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
种属内	HOXC4	P09017	GRN	Homo sapiens	P28799	Validated Y2H	32814053
种属内	HOXC4	P09017	GRN	Homo sapiens	P28799	Y2H Array	32814053
种属内	HOXC4	P09017	RPRD1B	Homo sapiens	Q9NQG5	Validated Y2H	32296183
种属内	HOXC4	P09017	HLA-A	Homo sapiens	Q5SUL5	Validated Y2H	32814053
种属内	HOXC4	P09017	HLA-A	Homo sapiens	Q5SUL5	Y2H Pooling	32814053
种属内	HOXC4	P09017	HLA-A	Homo sapiens	Q5SUL5	Y2H Array	32814053
种属内	HOXC4	P09017	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
种属内	HOXC4	P09017	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
种属内	HOXC4	P09017	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
种属内	HOXC4	P09017	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
种属内	HOXC4	P09017	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
种属内	HOXC4	P09017	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
种属内	HOXC4	P09017	SNCA	Homo sapiens	P37840	Y2H Array	32814053
种属内	HOXC4	P09017	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053
种属内	HOXC4	P09017	SNCA	Homo sapiens	P37840	Validated Y2H	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Ichthyosis, Congenital, Autosomal Recessive 11

Autosomal Recessive Congenital Ichthyosis 11	Ichthyosis With Hypotrichosis, Autosomal Recessive
Arih	Ichthyosis And Follicular Atrophoderma With Hypotrichosis And Hypohidrosis
Autosomal Recessive Ichthyosis With Hypotrichosis	ARCI11
Ifah	Hypotrichosis-Congenital Ichthyosis Syndrome
Ichthyosis-Follicular Atrophoderma-Hypotrichosis Syndrome	Ichthyosis-Follicular Atrophoderma-Hypotrichosis-Hypohidrosis Syndrome
Ichthyosis-Hypotrichosis Syndrome	Ifah Syndrome
Ihs

Immunodeficiency With Hyper-Igm, Type 2

HIGM2	Hyper-Igm Syndrome Type 2
Hyper-Igm Syndrome 2	Immunodeficiency With Hyper-Igm Type 2
Activation-Induced Cytidine Deaminase Deficiency	Aid Deficiency
Immunodeficiency With Hyper Igm Type 2	Hyper Igm Syndrome 2
Immunodeficiency With Hyper-Igm 2	Hyper-Igm Immunodeficiency Type 2
Immunodeficiency, With Hyper Igm, Type 2	Hyper-Igm Immunodeficiency Syndrome, Type 2

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma	Lymphoma, Non-Hodgkin
NHL	Lymphoma, Non-Hodgkin, Somatic
Lymphoma, Follicular, Somatic	Familial Non-Hodgkin Lymphoma
Lymphoma Non-Hodgkins	Follicular Lymphoma, Somatic
Lymphosarcoma	Non-Hodgkins Lymphoma

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06317	HOXC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	HOXC4	MGD	MGI:96195
Bos taurus	HOXC4	VGNC	VGNC:29925
Felis catus	HOXC4	VGNC	VGNC:84031
Canis familiaris	HOXC4	VGNC	VGNC:41759
Rattus norvegicus	HOXC4	RGD	RGD:1586210

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