A2M - alpha-2-macroglobulin Gene

中文名称：α-2-巨球蛋白

种属: Homo sapiens

同用名: A2MD; CPAMD5; FWP007; S863-7

基因 ID: 2 | 基因类型: protein coding

关于 A2M

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:9,067,708-9,116,229 (from NCBI)

This gene has 13 transcripts (splice variants), 228 orthologues and 8 paralogues. Broad expression in lung (RPKM 732.0), urinary bladder (RPKM 374.7) and 21 other tissues.

功能概要

该基因编码的蛋白质是一种蛋白酶抑制剂和细胞因子转运蛋白。它使用诱饵和陷阱机制来抑制广谱蛋白酶，包括胰蛋白酶、凝血酶和胶原酶。它还可以抑制炎症细胞因子，从而破坏炎症级联反应。该基因的突变是 alpha-2-巨球蛋白缺乏症的一个原因。该基因与阿尔茨海默病 (AD) 有关，因为它能够介导 A-β (β-淀粉样蛋白沉积物的主要成分) 的清除和降解。已经鉴定出一个相关的假基因，它也位于 12 号染色体的 p 臂上。[RefSeq 提供，2016 年 11 月]

The protein encoded by this gene is a Protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, Thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]

A2M 基因产物(4)

mRNA	Protein	Name
NM_000014.6	NP_000005.3	alpha-2-macroglobulin isoform a precursor
NM_001347423.2	NP_001334352.2	alpha-2-macroglobulin isoform a precursor
NM_001347424.2	NP_001334353.2	alpha-2-macroglobulin isoform b
NM_001347425.2	NP_001334354.2	alpha-2-macroglobulin isoform c

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables calcium-dependent protein binding	IPI IPI: 通过物理相互作用推断	15226301	GOA
enables endopeptidase inhibitor activity	IDA IDA: 通过直接分析推断	7679575	GOA
enables enzyme binding	IPI IPI: 通过物理相互作用推断	11435418	GOA
enables growth factor binding	IDA IDA: 通过直接分析推断	9398211	GOA
enables interleukin-1 binding	IDA IDA: 通过直接分析推断	9714181	GOA
enables interleukin-8 binding	IPI IPI: 通过物理相互作用推断	10880251	GOA
enables protease binding	IPI IPI: 通过物理相互作用推断	7679575	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	6698368	GOA
enables serine-type endopeptidase inhibitor activity	IDA IDA: 通过直接分析推断	12538697	GOA
enables signaling receptor binding	IMP IMP: 通过突变表型推断	15226301	GOA
enables tumor necrosis factor binding	IDA IDA: 通过直接分析推断	9714181	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of complement activation, lectin pathway	IDA IDA: 通过直接分析推断	12538697	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

A2M 蛋白结构

A2M_N

A2M_N_2

A2M

Thiol-ester_cl

A2M_comp

A2M_recep

0
300
600
900
1200
1474 a.a.

蛋白主名

其他名称

alpha-2-macroglobulin

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5

重组 A2M 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72823	Alpha-2-macroglobulin Protein, Human (sf9, His)	NP_000005.2 (S24-A1474)	≥95%

关联疾病

疾病名称

别名

Alpha-2-Macroglobulin Deficiency

A2MD

Mastitis

Breast Inflammation	Inflammatory Breast Disease
Inflammatory Disease Of Breast	Inflammation Of Non-Human Mammary Gland
Inflammatory Disorder Of Breast	Mastitis Nos
Acute Mastitis Nos	Acute Nonpuerperal Mastitis
Nonpuerperal Mastitis Nos	Subacute Mastitis Nos

Subendocardial Myocardial Infarction

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome	Ns - [Nephrotic Syndrome]
Nephrosis Syndrome	Nephrosis Nos
Glomerular Lesion Nephrosis

Cerebral Amyloid Angiopathy, Cst3-Related

Cerebral Amyloid Angiopathy	Hereditary Cerebral Hemorrhage With Amyloidosis
Hchwa	Hereditary Cystatin C Amyloid Angiopathy
Cerebral Amyloid Angiopathy, Familial	Amyloidosis, Cerebroarterial, Icelandic Type
Amyloidosis Vi	Cerebral Hemorrhage, Hereditary, With Amyloidosis
Cst3-Related Cerebral Amyloid Angiopathy	Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant
Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant	Caa, Familial
Cerebral Amyloid Angiopathy, Genetic	Acys Amyloidosis
Cst3-Related Amyloidosis	Cystatin Amyloidosis
Hchwa, Icelandic Type	Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type
Amyloidosis 6	AMYL6
Acys	Caa
Cerebral Amyloid Angiopathy Cst3-Related	Cerebroarterial Amyloidosis Icelandic Type
Cystatin C Amyloidosis	Hccaa
Hchwai	Hchwa-I
Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type	Cerebral Amyloid Angiopathy Familial
Angiopathy, Amyloid, Cerebral, Cst3-Related	Hereditary Cerebral Amyloid Angiopathy, Icelandic Type
Familial Cerebral Amyloid Angiopathy	Cerebral Amyloid Angiopathy, Hereditary

Breast Intraductal Papillomatosis

Breast Papillomatosis

Intraductal Papillomatosis Of The Breast

Disseminated Chorioretinitis

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00010	A2M Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	A2M	RGD	RGD:2004
Felis catus	A2M	VGNC	VGNC:97332
Mus musculus	A2M	MGD	MGI:2449119
Bos taurus	A2M	VGNC	VGNC:55837
Others	A2M	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

A2M - alpha-2-macroglobulin Gene

关于 A2M

功能概要

A2M 基因产物(4)

A2M 蛋白结构

重组 A2M 蛋白

关联疾病

直系同源

热门区域

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A2M - alpha-2-macroglobulin Gene

关于 A2M

功能概要

A2M 基因产物(4)

A2M 蛋白结构

重组 A2M 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z