2. Gene
  3. PIAS1 - protein inhibitor of activated STAT 1 Gene

PIAS1 - protein inhibitor of activated STAT 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：激活的 STAT 1 蛋白抑制因子

种属: Homo sapiens

同用名: GBP; ZMIZ3; DDXBP1; GU/RH-II

基因 ID: 8554 | 基因类型: protein coding

关于 PIAS1

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:68,054,315-68,193,847 (from NCBI)

This gene has 8 transcripts (splice variants), 297 orthologues and 5 paralogues. Ubiquitous expression in thyroid (RPKM 10.0), ovary (RPKM 9.9) and 25 other tissues.

功能概要

该基因编码激活 STAT (PIAS) 蛋白抑制剂家族的成员。 PIAS 蛋白作为 SUMO E3 连接酶发挥作用，并通过介导靶蛋白的 SUMO 化在许多细胞过程中发挥重要作用。这种蛋白质作为众多细胞通路的转录辅助调节因子发挥着核心作用，包括 STAT1 和核因子 kappaB 通路。交替剪接导致多个转录本变体。[RefSeq 提供，2016 年 3 月]

This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 Ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

PIAS1 基因产物(2)

mRNA Protein Name
NM_001320687.1 NP_001307616.1 E3 SUMO-protein ligase PIAS1 isoform 1
NM_016166.3 NP_057250.1 E3 SUMO-protein ligase PIAS1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SUMO ligase activity IDA
IDA: 通过直接分析推断
18579533 GOA
enables SUMO transferase activity EXP
EXP: 通过实验结果推断
12356736 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
17087506 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14752048 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
36050397 GOA
involved in positive regulation of protein sumoylation IDA
IDA: 通过直接分析推断
17696781 GOA
involved in protein sumoylation IDA
IDA: 通过直接分析推断
18579533 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
14752048 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PIAS1 蛋白结构

PINIT

PINIT: PINIT domain (131 - 286)

zf-MIZ

zf-MIZ: MIZ/SP-RING zinc finger (331 - 379)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 651 a.a.
蛋白主名 其他名称

E3 SUMO-protein ligase PIAS1

AR interacting protein

PIAS1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PIAS1 O75925 NF2 Homo sapiens P35240
Validated Y2H
32814053
Intra PIAS1 O75925 NF2 Homo sapiens P35240
Y2H Array
32814053
Intra PIAS1 O75925 NF2 Homo sapiens P35240
Y2H Pooling
32814053
Intra PIAS1 O75925 YARS1 Homo sapiens P54577
Validated Y2H
32814053
Intra PIAS1 O75925 YARS1 Homo sapiens P54577
Y2H Array
32814053
Intra PIAS1 O75925 YARS1 Homo sapiens P54577
Y2H Pooling
32814053
Intra PIAS1 O75925 MECP2 Homo sapiens P51608
Validated Y2H
32814053
Intra PIAS1 O75925 MECP2 Homo sapiens P51608
Y2H Pooling
32814053
Intra PIAS1 O75925 MECP2 Homo sapiens P51608
Y2H Array
32814053
Intra PIAS1 O75925 PPT1 Homo sapiens P50897
Y2H Array
32814053
Intra PIAS1 O75925 PPT1 Homo sapiens P50897
Validated Y2H
32814053
Intra PIAS1 O75925 PPT1 Homo sapiens P50897
Y2H Pooling
32814053
Intra PIAS1 O75925 GLE1 Homo sapiens Q53GS7
Y2H Pooling
32814053
Intra PIAS1 O75925 GLE1 Homo sapiens Q53GS7
Validated Y2H
32814053
Intra PIAS1 O75925 GLE1 Homo sapiens Q53GS7
Y2H Array
32814053
Intra PIAS1 O75925 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra PIAS1 O75925 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra PIAS1 O75925 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra PIAS1 O75925 CASP8AP2 Homo sapiens Q9UKL3
Y2H
21338522
Intra PIAS1 O75925 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra PIAS1 O75925 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra PIAS1 O75925 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra PIAS1 O75925 CCT5 Homo sapiens P48643
Y2H Array
32814053
Intra PIAS1 O75925 CCT5 Homo sapiens P48643
Y2H Pooling
32814053
Intra PIAS1 O75925 CCT5 Homo sapiens P48643
Validated Y2H
32814053
Intra PIAS1 O75925 TP53 Homo sapiens P04637
Pull Down
15133049
Intra PIAS1 O75925 SMN1 Homo sapiens Q16637
Validated Y2H
32814053
Intra PIAS1 O75925 SMN1 Homo sapiens Q16637
Y2H Pooling
32814053
Intra PIAS1 O75925 SMN1 Homo sapiens Q16637
Y2H Array
32814053
Intra PIAS1 O75925 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra PIAS1 O75925 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra PIAS1 O75925 HTT Homo sapiens P42858
Y2H Array
32814053
Intra PIAS1 O75925 HTRA2 Homo sapiens O43464
Validated Y2H
32814053
Intra PIAS1 O75925 HTRA2 Homo sapiens O43464
Y2H Pooling
32814053
Intra PIAS1 O75925 HTRA2 Homo sapiens O43464
Y2H Array
32814053
Intra PIAS1 O75925 ATXN10 Homo sapiens Q9UBB4
Y2H Pooling
32814053
Intra PIAS1 O75925 ATXN10 Homo sapiens Q9UBB4
Validated Y2H
32814053
Intra PIAS1 O75925 ATXN10 Homo sapiens Q9UBB4
Y2H Array
32814053
Intra PIAS1 O75925 NDUFV2 Homo sapiens P19404
Validated Y2H
32814053
Intra PIAS1 O75925 NDUFV2 Homo sapiens P19404
Y2H Array
32814053
Intra PIAS1 O75925 NDUFV2 Homo sapiens P19404
Y2H Pooling
32814053
Intra PIAS1 O75925 PHYH Homo sapiens O14832
Y2H Array
32814053
Intra PIAS1 O75925 PHYH Homo sapiens O14832
Validated Y2H
32814053
Intra PIAS1 O75925 PHYH Homo sapiens O14832
Y2H Pooling
32814053
Intra PIAS1 O75925 SNCB Homo sapiens Q16143
Y2H Pooling
32814053
Intra PIAS1 O75925 SNCB Homo sapiens Q16143
Validated Y2H
32814053
Intra PIAS1 O75925 SNCB Homo sapiens Q16143
Y2H Array
32814053
Intra PIAS1 O75925 ASPA Homo sapiens P45381
Validated Y2H
32814053
Intra PIAS1 O75925 ASPA Homo sapiens P45381
Y2H Array
32814053
Intra PIAS1 O75925 ASPA Homo sapiens P45381
Y2H Pooling
32814053
Intra PIAS1 O75925 PRPH Homo sapiens P41219
Validated Y2H
32814053
Intra PIAS1 O75925 PRPH Homo sapiens P41219
Y2H Pooling
32814053
Intra PIAS1 O75925 PRPH Homo sapiens P41219
Y2H Array
32814053
Intra PIAS1 O75925 MBD1 Homo sapiens Q9UIS9
Anti Bait CoIP
17066076
Intra PIAS1 O75925 MBD1 Homo sapiens Q9UIS9
Pull Down
17066076
Intra PIAS1 O75925 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Intra PIAS1 O75925 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Intra PIAS1 O75925 ATXN1 Homo sapiens P54253
Y2H Prey Pooling
23275563
Intra PIAS1 O75925 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra PIAS1 O75925 ATXN3 Homo sapiens P54252
Y2H Pooling
32814053
Intra PIAS1 O75925 ATXN3 Homo sapiens P54252
Validated Y2H
32814053
Intra PIAS1 O75925 ATXN3 Homo sapiens P54252
Y2H Array
32814053
Intra PIAS1 O75925 PRDM1 Homo sapiens O75626
Anti Bait CoIP
22555612
Intra PIAS1 O75925 PRDM1 Homo sapiens O75626
Anti Tag CoIP
22555612
Intra PIAS1 O75925 SNCA Homo sapiens P37840
Validated Y2H
32814053
Intra PIAS1 O75925 SNCA Homo sapiens P37840
Y2H Array
32814053
Intra PIAS1 O75925 SNCA Homo sapiens P37840
Y2H Pooling
32814053
Intra PIAS1 O75925 PEX1 Homo sapiens O43933
Validated Y2H
32814053
Intra PIAS1 O75925 PEX1 Homo sapiens O43933
Y2H Array
32814053
Intra PIAS1 O75925 PEX1 Homo sapiens O43933
Y2H Pooling
32814053
Cross PIAS1 O75925 P29991-PRO_0000037946 Dengue virus type 2 P29991-PRO_0000037946
Y2H
21911577
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nephronophthisis

Medullary Cystic Disease

Medullary Cystic Kidney

Nph

Nphp

Kidney Disease, Cystic, Medullary
Germ Cell Cancer

Malignant Germ Cell Tumor

Neoplasms, Germ Cell And Embryonal

Germ Cell Neoplasm

Germ Cell Tumour

Malignant Tumor Of The Germ Cell

Neoplasms Germ Cell

Malignant Germ Cell Neoplasm
Borderline Glaucoma

Preglaucoma
Unilateral Focal Polymicrogyria
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W062696 BC-1382 Inhibitor 99.53% 否
HY-RS10473 PIAS1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PIAS1 VGNC VGNC:75876
Rattus norvegicus PIAS1 RGD RGD:1307843
Bos taurus PIAS1 VGNC VGNC:32856
Mus musculus PIAS1 MGD MGI:1913125
Felis catus PIAS1 VGNC VGNC:64159
Canis familiaris PIAS1 VGNC VGNC:44519
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z