1. Gene
  2. SUV39H1 - SUV39H1 histone lysine methyltransferase Gene

SUV39H1 - SUV39H1 histone lysine methyltransferase Gene

中文名称:SUV39H1 组蛋白赖氨酸甲基转移酶

种属: Homo sapiens

同用名: MG44; KMT1A; SUV39H; H3-K9-HMTase 1

基因 ID: 6839 | 基因类型: protein coding

关于 SUV39H1

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,695,554-48,709,016 (from NCBI)

This gene has 4 transcripts (splice variants), 221 orthologues and 19 paralogues. Ubiquitous expression in bone marrow (RPKM 4.9), lymph node (RPKM 3.6) and 24 other tissues.

功能概要

该基因编码一种进化上保守的蛋白质,其中包含一个 N 端染色域和一个 C 端 SET 域。编码的蛋白质是一种组蛋白甲基转移酶,可使组蛋白 H3 的赖氨酸 9 三甲基化,从而导致转录基因沉默。该基因功能的丧失会破坏异染色质的形成,并可能导致染色体不稳定。可变剪接导致多个转录本变体。[RefSeq 提供,2013 年 8 月]

This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a Histone Methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

SUV39H1 基因产物(2)

mRNA Protein Name
NM_001282166.2 NP_001269095.1 histone-lysine N-methyltransferase SUV39H1 isoform 1
NM_003173.4 NP_003164.1 histone-lysine N-methyltransferase SUV39H1 isoform 2

SUV39H1 蛋白结构

Chromo

Chromo: Chromo (CHRromatin Organisation MOdifier) domain (43 - 91)

Pre-SET

Pre-SET: Pre-SET motif (139 - 235)

SET

SET: SET domain (255 - 366)

  • 0
  • 100
  • 200
  • 300
  • 412 a.a.
蛋白主名 其他名称

histone-lysine N-methyltransferase SUV39H1

Su(var)3-9 homolog 1

SUV39H1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SUV39H1 O43463 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
种属内
SUV39H1 O43463 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
种属内
SUV39H1 O43463 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
种属内
SUV39H1 O43463 KRTAP10-7 Homo sapiens P60409
Validated Y2H
32296183
种属内
SUV39H1 O43463 KRTAP10-7 Homo sapiens P60409
Y2H Array
25416956
种属内
SUV39H1 O43463 KRTAP10-7 Homo sapiens P60409
Y2H Array
32296183
种属内
SUV39H1 O43463 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
种属内
SUV39H1 O43463 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
32296183
种属内
SUV39H1 O43463 HEL25 Homo sapiens V9HWG0
Validated Y2H
25416956
种属内
SUV39H1 O43463 HEL25 Homo sapiens V9HWG0
Y2H Array
25416956
种属内
SUV39H1 O43463 ATE1 Homo sapiens O95260
Y2H
23455924
种属内
SUV39H1 O43463 PADI6 Homo sapiens Q6TGC4
Y2H Prey Pooling
32296183
种属内
SUV39H1 O43463 PADI6 Homo sapiens Q6TGC4
Validated Y2H
32296183
种属内
SUV39H1 O43463 PADI6 Homo sapiens Q6TGC4
Y2H Array
32296183
种属内
SUV39H1 O43463 HOOK2 Homo sapiens Q96ED9-2
Validated Y2H
32296183
种属内
SUV39H1 O43463 HOOK2 Homo sapiens Q96ED9-2
Y2H Prey Pooling
32296183
种属内
SUV39H1 O43463 HOOK2 Homo sapiens Q96ED9-2
Y2H Array
32296183
种属内
SUV39H1 O43463 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
种属内
SUV39H1 O43463 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
种属内
SUV39H1 O43463 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
种属内
SUV39H1 O43463 ZNF438 Homo sapiens Q7Z4V0
Y2H Prey Pooling
32296183
种属内
SUV39H1 O43463 ZNF438 Homo sapiens Q7Z4V0
Validated Y2H
32296183
种属内
SUV39H1 O43463 ZNF438 Homo sapiens Q7Z4V0
Y2H Array
32296183
种属内
SUV39H1 O43463 RRP8 Homo sapiens O43159
Anti Tag CoIP
18485871
种属内
SUV39H1 O43463 KLK6 Homo sapiens Q92876
Validated Y2H
32814053
种属内
SUV39H1 O43463 KLK6 Homo sapiens Q92876
Y2H Pooling
32814053
种属内
SUV39H1 O43463 KLK6 Homo sapiens Q92876
Y2H Array
32814053
种属内
SUV39H1 O43463 ZBTB2 Homo sapiens Q8N680
Y2H Prey Pooling
32296183
种属内
SUV39H1 O43463 ZBTB2 Homo sapiens Q8N680
Validated Y2H
32296183
种属内
SUV39H1 O43463 ZBTB2 Homo sapiens Q8N680
Y2H Array
32296183
种属内
SUV39H1 O43463 SPSB1 Homo sapiens Q96BD6
Anti Tag CoIP
23455924
种属内
SUV39H1 O43463 ZKSCAN5 Homo sapiens Q9Y2L8
Anti Tag CoIP
23455924
种属内
SUV39H1 O43463 ZKSCAN5 Homo sapiens Q9Y2L8
Y2H
23455924
种属内
SUV39H1 O43463 TGFBR2 Homo sapiens P37173
Y2H Pooling
32814053
种属内
SUV39H1 O43463 TGFBR2 Homo sapiens P37173
Validated Y2H
32814053
种属内
SUV39H1 O43463 TGFBR2 Homo sapiens P37173
Y2H Array
32814053
种属内
SUV39H1 O43463 HDAC2 Homo sapiens Q92769
Anti Tag CoIP
12711603
种属内
SUV39H1 O43463 HDAC2 Homo sapiens Q92769
Pull Down
12711603
种属内
SUV39H1 O43463 HDAC1 Homo sapiens Q13547
Pull Down
12711603
种属内
SUV39H1 O43463 HDAC1 Homo sapiens Q13547
Anti Tag CoIP
12711603
种属内
SUV39H1 O43463 SERPINH1 Homo sapiens P50454
Validated Y2H
32814053
种属内
SUV39H1 O43463 SERPINH1 Homo sapiens P50454
Y2H Array
32814053
种属内
SUV39H1 O43463 SERPINH1 Homo sapiens P50454
Y2H Pooling
32814053
种属内
SUV39H1 O43463 ZNF649 Homo sapiens Q9BS31
Y2H
23455924
种属内
SUV39H1 O43463 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
种属内
SUV39H1 O43463 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
种属内
SUV39H1 O43463 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
种属内
SUV39H1 O43463 EZH2 Homo sapiens Q15910
Y2H
23455924
种属内
SUV39H1 O43463 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
种属内
SUV39H1 O43463 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
种属内
SUV39H1 O43463 U2AF1 Homo sapiens Q01081
Y2H
23455924
种属内
SUV39H1 O43463 BCL11B Homo sapiens Q9C0K0
Anti Bait CoIP
17245431
种属内
SUV39H1 O43463 PPP1R16A Homo sapiens Q96I34
Y2H Prey Pooling
32296183
种属内
SUV39H1 O43463 PPP1R16A Homo sapiens Q96I34
Validated Y2H
32296183
种属内
SUV39H1 O43463 PPP1R16A Homo sapiens Q96I34
Y2H Array
32296183
种属内
SUV39H1 O43463 TRIM41 Homo sapiens Q8WV44
Y2H Array
32296183
种属内
SUV39H1 O43463 TRIM41 Homo sapiens Q8WV44
Validated Y2H
32296183
种属内
SUV39H1 O43463 TRIM41 Homo sapiens Q8WV44
Y2H Prey Pooling
32296183
种属内
SUV39H1 O43463 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
25416956
种属内
SUV39H1 O43463 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
32296183
种属内
SUV39H1 O43463 DVL3 Homo sapiens Q92997
Validated Y2H
32296183
种属内
SUV39H1 O43463 DVL3 Homo sapiens Q92997
Y2H Array
32296183
种属内
SUV39H1 O43463 ZNF417 Homo sapiens Q8TAU3
Y2H Prey Pooling
32296183
种属内
SUV39H1 O43463 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
32296183
种属内
SUV39H1 O43463 ZNF417 Homo sapiens Q8TAU3
Y2H Array
32296183
种属内
SUV39H1 O43463 HOXA1 Homo sapiens P49639
Anti Tag CoIP
23455924
种属内
SUV39H1 O43463 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
种属内
SUV39H1 O43463 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
种属内
SUV39H1 O43463 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
种属内
SUV39H1 O43463 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
32296183
种属内
SUV39H1 O43463 LZTS2 Homo sapiens Q9BRK4
Y2H Array
25416956
种属内
SUV39H1 O43463 ZNF670 Homo sapiens Q9BS34
Anti Tag CoIP
23455924
种属内
SUV39H1 O43463 ZNF670 Homo sapiens Q9BS34
Y2H
23455924
种属内
SUV39H1 O43463 RAD23A Homo sapiens P54725
Y2H Array
32814053
种属内
SUV39H1 O43463 RAD23A Homo sapiens P54725
Validated Y2H
32814053
种属内
SUV39H1 O43463 RAD23A Homo sapiens P54725
Y2H Pooling
32814053
种属内
SUV39H1 O43463 TEKT4 Homo sapiens Q8WW24
Validated Y2H
32296183
种属内
SUV39H1 O43463 CBX1 Homo sapiens P83916
Anti Tag CoIP
33961781
种属内
SUV39H1 O43463 CBX1 Homo sapiens P83916
Validated Y2H
32296183
种属内
SUV39H1 O43463 CBX1 Homo sapiens P83916
Y2H Array
32296183
种属内
SUV39H1 O43463 CBX1 Homo sapiens P83916
Y2H Prey Pooling
32296183
种属内
SUV39H1 O43463 CBX1 Homo sapiens P83916
TAP
27705803
种属内
SUV39H1 O43463 CBX3 Homo sapiens Q13185
TAP
24981860
种属内
SUV39H1 O43463 CBX3 Homo sapiens Q13185
TAP
27705803
种属内
SUV39H1 O43463 CBX3 Homo sapiens Q13185
Anti Tag CoIP
33961781
种属内
SUV39H1 O43463 CBX3 Homo sapiens Q13185
Validated Y2H
32296183
种属内
SUV39H1 O43463 CBX3 Homo sapiens Q13185
Y2H Prey Pooling
32296183
种属内
SUV39H1 O43463 CBX3 Homo sapiens Q13185
Y2H Array
32296183
种属内
SUV39H1 O43463 CBX5 Homo sapiens P45973
TAP
27705803
种属内
SUV39H1 O43463 CBX5 Homo sapiens P45973
Y2H Pooling
16189514
种属内
SUV39H1 O43463 CBX5 Homo sapiens P45973
Validated Y2H
32296183
种属内
SUV39H1 O43463 CBX5 Homo sapiens P45973
Anti Bait CoIP
25931448
种属内
SUV39H1 O43463 CBX5 Homo sapiens P45973
TAP
24981860
种属内
SUV39H1 O43463 CBX5 Homo sapiens P45973
Anti Tag CoIP
33961781
种属内
SUV39H1 O43463 CBX5 Homo sapiens P45973
Y2H Array
32296183
种属内
SUV39H1 O43463 CBX5 Homo sapiens P45973
Anti Tag CoIP
28514442
种属内
SUV39H1 O43463 CBX5 Homo sapiens P45973
Pull Down
12711603
种属内
SUV39H1 O43463 CBX5 Homo sapiens P45973
Y2H Prey Pooling
32296183
种属内
SUV39H1 O43463 C8orf74 Homo sapiens Q6P047
Anti Tag CoIP
23455924
种属内
SUV39H1 O43463 ODAD3 Homo sapiens A5D8V7
Anti Tag CoIP
23455924
种属内
SUV39H1 O43463 ODAD3 Homo sapiens A5D8V7
Y2H
23455924
种属内
SUV39H1 O43463 KLHDC4 Homo sapiens Q8TBB5
Anti Tag CoIP
23455924
种属内
SUV39H1 O43463 ZNF436 Homo sapiens Q9C0F3
Anti Tag CoIP
23455924
种属内
SUV39H1 O43463 ZNF436 Homo sapiens Q9C0F3
Y2H
23455924
种属内
SUV39H1 O43463 MBD1 Homo sapiens Q9UIS9
Pull Down
12711603
种属内
SUV39H1 O43463 MBD1 Homo sapiens Q9UIS9
Confocal
12711603
种属内
SUV39H1 O43463 MBD1 Homo sapiens Q9UIS9
Anti Tag CoIP
12711603
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hutchinson-Gilford Progeria Syndrome

Progeria

HGPS

Hutchinson-Gilford Syndrome

Hutchinson-Gilford Progeria

Hutchinson Gilford Syndrome

Hutchinson Gilford Progeria Syndrome

Hutchinson-Gilford Disease

Progeria Of Childhood

Hutchinson-Gilford-Progeria Syndrome

Hyperoxaluria, Primary, Type I

Primary Hyperoxaluria Type 1

HP1

Glycolic Aciduria

Alanine-Glyoxylate Aminotransferase Deficiency

Hepatic Agt Deficiency

Oxalosis I

Primary Hyperoxaluria, Type I

Serine:Pyruvate Aminotransferase Deficiency

Hyperoxaluria, Primary, Type 1

Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency

Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency

Serine Pyruvate Aminotransferase Deficiency

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Oxalosis 1

Hyperoxaluria Primary 1

Hyperoxaluria Primary Type I

Ph1

Primary Hyperoxaluria Type I

Oxalosis Type 1

2-Oxoglutarate Glyoxylate Carboligase Deficiency

Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms

Primary Hyperoxaluria

Hyperoxaluria

Hyperoxaluria, Primary

Oxalosis

Primary Oxalosis

Congenital Oxaluria

D-Glycerate Dehydrogenase Deficiency

Glyceric Aciduria

Glycolic Aciduria

Hepatic Agt Deficiency

Oxaluria, Primary

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Primary Oxaluria

Hyperoxaluria Primary

Primary Hyperoxaluria Type 2

Primary Hyperoxaluria, Type I

Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

Icf Syndrome

Immunodeficiency Syndrome, Variable

Ciid

Centromeric Instability, Immunodeficiency Syndrome

Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16

Icf

Rhabdomyosarcoma
Alpha-Thalassemia

Alpha Thalassemia

Alpha Thalassaemia

Alpha Plus Thalassemia

Thalassemia, Alpha-

Thalassemias, Alpha-

A-Thalassemia

Α-Thalassemia

A-THAL

Thalassemia

Alpha Thalassaemia Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus SUV39H1 MGD MGI:1099440
Bos taurus SUV39H1 VGNC VGNC:35491
Canis familiaris SUV39H1 VGNC VGNC:47001
Felis catus SUV39H1 VGNC VGNC:65857
Macaca mulatta SUV39H1 VGNC VGNC:78061