2. Gene
  3. CBX3 - chromobox 3 Gene

CBX3 - chromobox 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：色盒 3

种属: Homo sapiens

同用名: HECH; HP1-GAMMA; HP1Hs-gamma

基因 ID: 11335 | 基因类型: protein coding

关于 CBX3

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:26,201,443-26,213,607 (from NCBI)

This gene has 8 transcripts (splice variants), 183 orthologues and 8 paralogues. Ubiquitous expression in lymph node (RPKM 47.3), testis (RPKM 43.1) and 25 other tissues.

功能概要

在核膜上，核层和异染色质与内核膜相邻。该基因编码的蛋白质与 DNA 结合，是异染色质的组成部分。这种蛋白质还可以结合核纤层蛋白 B 受体，核纤层蛋白 B 受体是一种在内核膜中发现的完整膜蛋白。编码蛋白的双重结合功能可以解释异染色质与内核膜的关联。该蛋白结合在 Lys-9 位点甲基化的组蛋白 H3 尾部。这种蛋白质也被募集到紫外线引起的 DNA 损伤和双链断裂的位点。已针对该基因发现编码相同蛋白质但 5' UTR 不同的两个转录变体。[RefSeq 提供，2011 年 3 月]

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]

CBX3 基因产物(3)

mRNA Protein Name
NM_001410866.1 NP_001397795.1 chromobox protein homolog 3 isoform b
NM_007276.5 NP_009207.2 chromobox protein homolog 3 isoform a
NM_016587.4 NP_057671.2 chromobox protein homolog 3 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme binding IPI
IPI: 通过物理相互作用推断
19486527 GOA
enables histone methyltransferase binding IPI
IPI: 通过物理相互作用推断
19486527 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
19486527 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
8663349 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
8663349 GOA
enables transcription coregulator binding IPI
IPI: 通过物理相互作用推断
29795351 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IMP
IMP: 通过突变表型推断
27248496 GOA
involved in heterochromatin formation IDA
IDA: 通过直接分析推断
17540172 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
9636147 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
9636147 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex IDA
IDA: 通过直接分析推断
29795351 GOA
located in chromatin IDA
IDA: 通过直接分析推断
11101528 GOA
part of chromatin lock complex IPI
IPI: 通过物理相互作用推断
17540172 GOA
located in chromosome, centromeric region IDA
IDA: 通过直接分析推断
10504293 GOA
located in euchromatin IDA
IDA: 通过直接分析推断
11124534 GOA
located in heterochromatin IDA
IDA: 通过直接分析推断
11124534 GOA
located in nucleus IDA
IDA: 通过直接分析推断
17540172 GOA
located in site of DNA damage IMP
IMP: 通过突变表型推断
27248496 GOA
located in spindle IDA
IDA: 通过直接分析推断
11101528 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CBX3 蛋白结构

Chromo

Chromo: Chromo (CHRromatin Organisation MOdifier) domain (30 - 78)

Chromo_shadow

Chromo_shadow: Chromo shadow domain (119 - 176)

  • 0
  • 100
  • 183 a.a.
蛋白主名 其他名称

chromobox protein homolog 3

HP1 gamma homolog

CBX3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CBX3 Q13185 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra CBX3 Q13185 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra CBX3 Q13185 ADAMTSL4 Homo sapiens Q6UY14-3
Validated Y2H
32296183
Intra CBX3 Q13185 LBR Homo sapiens Q14739
Y2H
8663349
Intra CBX3 Q13185 ZNF280D Homo sapiens Q6N043-2
Y2H Prey Pooling
32296183
Intra CBX3 Q13185 ZNF280D Homo sapiens Q6N043-2
Validated Y2H
32296183
Intra CBX3 Q13185 ZNF280D Homo sapiens Q6N043-2
Y2H Array
32296183
Intra CBX3 Q13185 ADNP Homo sapiens Q9H2P0
Anti Bait CoIP
36950384
Intra CBX3 Q13185 ADNP Homo sapiens Q9H2P0
Anti Tag CoIP
33961781
Intra CBX3 Q13185 ADNP Homo sapiens Q9H2P0
TAP
24981860
Intra CBX3 Q13185 ADNP Homo sapiens Q9H2P0
TAP
27705803
Intra CBX3 Q13185 ADNP Homo sapiens Q9H2P0
TAP
21888893
Intra CBX3 Q13185 GDF15 Homo sapiens Q99988
Validated Y2H
32296183
Intra CBX3 Q13185 GDF15 Homo sapiens Q99988
Y2H Array
32296183
Intra CBX3 Q13185 GDF15 Homo sapiens Q99988
Y2H Prey Pooling
32296183
Intra CBX3 Q13185 LAP3 Homo sapiens P28838
Y2H Array
32296183
Intra CBX3 Q13185 LAP3 Homo sapiens P28838
Y2H Prey Pooling
32296183
Intra CBX3 Q13185 MGA Homo sapiens Q8IWI9
TAP
24981860
Intra CBX3 Q13185 MGA Homo sapiens Q8IWI9
TAP
27705803
Intra CBX3 Q13185 MGA Homo sapiens Q8IWI9
Anti Tag CoIP
33961781
Intra CBX3 Q13185 ADNP2 Homo sapiens Q6IQ32
TAP
27705803
Intra CBX3 Q13185 ADNP2 Homo sapiens Q6IQ32
Anti Tag CoIP
33961781
Intra CBX3 Q13185 ADNP2 Homo sapiens Q6IQ32
Y2H Prey Pooling
32296183
Intra CBX3 Q13185 ADNP2 Homo sapiens Q6IQ32
Validated Y2H
32296183
Intra CBX3 Q13185 ADNP2 Homo sapiens Q6IQ32
Y2H Array
32296183
Intra CBX3 Q13185 SUV39H1 Homo sapiens O43463
TAP
27705803
Intra CBX3 Q13185 MRPL12 Homo sapiens P52815
Y2H Prey Pooling
32296183
Intra CBX3 Q13185 MRPL12 Homo sapiens P52815
Y2H Array
32296183
Intra CBX3 Q13185 LRIF1 Homo sapiens Q5T3J3
TAP
27705803
Intra CBX3 Q13185 LRIF1 Homo sapiens Q5T3J3
TAP
21888893
Intra CBX3 Q13185 LRIF1 Homo sapiens Q5T3J3
Anti Tag CoIP
33961781
Intra CBX3 Q13185 LRIF1 Homo sapiens Q5T3J3
TAP
24981860
Intra CBX3 Q13185 LRIF1 Homo sapiens Q5T3J3
Validated Y2H
32296183
Intra CBX3 Q13185 PRR14 Homo sapiens Q9BWN1
TAP
27705803
Intra CBX3 Q13185 PRR14 Homo sapiens Q9BWN1
Y2H Prey Pooling
32296183
Intra CBX3 Q13185 PRR14 Homo sapiens Q9BWN1
Validated Y2H
32296183
Intra CBX3 Q13185 PRR14 Homo sapiens Q9BWN1
Y2H Array
32296183
Intra CBX3 Q13185 TRIM28 Homo sapiens Q13263
Y2H Pooling
20936779
Intra CBX3 Q13185 TRIM28 Homo sapiens Q13263
TAP
27705803
Intra CBX3 Q13185 TRIM28 Homo sapiens Q13263
TAP
21888893
Intra CBX3 Q13185 KMT5C Homo sapiens Q86Y97
Pull Down
19486527
Intra CBX3 Q13185 H3C1 Homo sapiens P68431
Protein Array
20871592
Intra CBX3 Q13185 H3C1 Homo sapiens P68431
TAP
24981860
Intra CBX3 Q13185 H3C1 Homo sapiens P68431
Pull Down
16415788
Intra CBX3 Q13185 ZNF280C Homo sapiens Q8ND82
Validated Y2H
32296183
Intra CBX3 Q13185 ZNF280C Homo sapiens Q8ND82
TAP
27705803
Cross CBX3 Q13185 legAS4 Legionella pneumophila subsp. pneumophila Q5ZUS4
Y2H
23797873
Cross CBX3 Q13185 legAS4 Legionella pneumophila subsp. pneumophila Q5ZUS4
Anti Bait CoIP
23797873
Intra CBX3 Q13185 RAD54L2 Homo sapiens Q9Y4B4
Y2H Prey Pooling
32296183
Intra CBX3 Q13185 RAD54L2 Homo sapiens Q9Y4B4
Validated Y2H
32296183
Intra CBX3 Q13185 RAD54L2 Homo sapiens Q9Y4B4
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hutchinson-Gilford Progeria Syndrome

Progeria

HGPS

Hutchinson-Gilford Syndrome

Hutchinson-Gilford Progeria

Hutchinson Gilford Syndrome

Hutchinson Gilford Progeria Syndrome

Hutchinson-Gilford Disease

Progeria Of Childhood

Hutchinson-Gilford-Progeria Syndrome
Hyperoxaluria, Primary, Type I

Primary Hyperoxaluria Type 1

HP1

Glycolic Aciduria

Alanine-Glyoxylate Aminotransferase Deficiency

Hepatic Agt Deficiency

Oxalosis I

Primary Hyperoxaluria, Type I

Serine:Pyruvate Aminotransferase Deficiency

Hyperoxaluria, Primary, Type 1

Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency

Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency

Serine Pyruvate Aminotransferase Deficiency

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Oxalosis 1

Hyperoxaluria Primary 1

Hyperoxaluria Primary Type I

Ph1

Primary Hyperoxaluria Type I

Oxalosis Type 1

2-Oxoglutarate Glyoxylate Carboligase Deficiency
Primary Hyperoxaluria

Hyperoxaluria

Hyperoxaluria, Primary

Oxalosis

Primary Oxalosis

Congenital Oxaluria

D-Glycerate Dehydrogenase Deficiency

Glyceric Aciduria

Glycolic Aciduria

Hepatic Agt Deficiency

Oxaluria, Primary

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Primary Oxaluria

Hyperoxaluria Primary

Primary Hyperoxaluria Type 2

Primary Hyperoxaluria, Type I
Cornelia De Lange Syndrome

De Lange Syndrome

Brachmann De Lange Syndrome

Brachmann-De Lange Syndrome

Cdls

Bdls

Typus Degenerativus Amstelodamensis
Facioscapulohumeral Muscular Dystrophy 1

Facioscapulohumeral Muscular Dystrophy

Fshd

Landouzy-Dejerine Muscular Dystrophy

Muscular Dystrophy, Facioscapulohumeral

FSHD1

Fshd1a

Muscular Dystrophy, Facioscapulohumeral, Type 1a

Facioscapulohumeral Muscular Dystrophy Type 1a

Fsh Muscular Dystrophy

Facioscapulohumeral Muscular Dystrophy 1a

Facioscapulohumeral Atrophy

Facioscapulohumeral Myopathy

Muscular Dystrophy, Facioscapulohumeral, Type 1

Facioscapulohumeral Muscular Dystrophy Type 1

Landouzy Dejerine Muscular Dystrophy

Muscular Dystrophy, Landouzy-Dejerine

Fshmd1a

Facio-Scapulo-Humeral Dystrophy

Facioscapulohumeral Type Progressive Muscular Dystrophy

Facioscapuloperoneal Muscular Dystrophy

Facioscapulohumeral Dystrophy

Fsh Dystrophy

Landouzy-Dejerine Dystrophy

Landouzy-Dejerine Myopathy

Fmd

Facioscapulohumeral Muscular Dystrophy-1a

Muscular Dystrophy Facioscapulohumeral

Dystrophy, Muscular, Facioscapulohumeral

Dystrophy, Muscular, Facioscapulohumeral, Type 1

Landouzy-Dejerine Disease

Landouzy-Déjerine Atrophy

Facioscapulohumeral Muscle Dystrophy

Fmd - [Facioscapulohumeral Muscular Dystrophy]

Fsh - [Facioscapulohumeral Muscular Dystrophy]

Fshd - [Facioscapulohumeral Muscular Dystrophy]

Landouzy-Déjerine Dystrophy Or Facioscapulohumeral Atrophy

Landouzy-Déjérine Muscular Dystrophy
Facioscapulohumeral Muscular Dystrophy 2, Digenic

Facioscapulohumeral Muscular Dystrophy 2

FSHD2

Fshd1b

Facioscapulohumeral Muscular Dystrophy 1b

Fshd2, Digenic

Muscular Dystrophy, Facioscapulohumeral, Type 2

Muscular Dystrophy, Facioscapulohumeral, Type 1b

Fascioscapulohumeral Muscular Dystrophy 2, Digenic

Facioscapulohumeral Muscular Dystrophy Type 2

Digenic Facioscapulohumeral Muscular Dystrophy

Digenic Fshd2

Facioscapulohumeral Muscular Dystrophy Type 1b

Dystrophy, Muscular, Facioscapulohumeral, Type 2
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

Icf Syndrome

Immunodeficiency Syndrome, Variable

Ciid

Centromeric Instability, Immunodeficiency Syndrome

Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16

Icf
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02010 CBX3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CBX3 VGNC VGNC:50017
Rattus norvegicus CBX3 RGD RGD:1549705
Mus musculus CBX3 MGD MGI:108515
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