MRPL12 - mitochondrial ribosomal protein L12 Gene

中文名称：线粒体核糖体蛋白 L12

种属: Homo sapiens

同用名: 5c5-2; L12mt; MRPL7; RPML12; MRPL7/L12; MRP-L31/34

基因 ID: 6182 | 基因类型: protein coding

关于 MRPL12

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,703,367-81,707,517 (from NCBI)

This gene has 1 transcript (splice variant), 182 orthologues and is associated with 1 phenotype. Ubiquitous expression in colon (RPKM 31.4), heart (RPKM 25.0) and 25 other tissues.

功能概要

哺乳动物线粒体核糖体蛋白由核基因编码，有助于线粒体内的蛋白质合成。线粒体核糖体 (线粒体核糖体) 由一个小的 28S 亚基和一个大的 39S 亚基组成。与原核核糖体相比，它们估计有 75% 的蛋白质与 rRNA 组成，而原核核糖体的比例是相反的。哺乳动物线粒体核糖体和原核核糖体之间的另一个区别是后者包含 5S rRNA。在不同的物种中，构成核糖体的蛋白质在序列上有很大差异，有时在生化特性上也有很大差异，这使得序列同源性难以识别。该基因编码形成同型二聚体的 39S 亚基蛋白。在原核核糖体中，两个 L7/L12 二聚体和一个 L10 蛋白形成 L8 蛋白复合物。[RefSeq 提供，2008 年 7 月]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex. [provided by RefSeq, Jul 2008]

MRPL12 基因产物(1)

mRNA	Protein	Name
NM_002949.4	NP_002940.2	39S ribosomal protein L12, mitochondrial

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	17337445	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in mitochondrial transcription	IDA IDA: 通过直接分析推断	17337445	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	17337445	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of mitochondrial large ribosomal subunit	IDA IDA: 通过直接分析推断	20186120	GOA
located in mitochondrial matrix	IDA IDA: 通过直接分析推断	27184847	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	17337445	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MRPL12 蛋白结构

Ribosomal_L12

0
100
198 a.a.

蛋白主名

其他名称

39S ribosomal protein L12, mitochondrial

MRP-L12

MRPL12 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MRPL12	P52815	TRIM59	Homo sapiens	Q8IWR1	Validated Y2H	32296183
种属内	MRPL12	P52815	MORF4L1	Homo sapiens	Q9UBU8-2	Validated Y2H	32296183
种属内	MRPL12	P52815	NTM	Homo sapiens	Q9P121-3	Validated Y2H	32296183
种属内	MRPL12	P52815	EFCAB2	Homo sapiens	Q5VUJ9-2	Validated Y2H	32296183
种属内	MRPL12	P52815	EXOC3L2	Homo sapiens	Q2M3D2	Validated Y2H	32296183
种属内	MRPL12	P52815	POLRMT	Homo sapiens	O00411	Anti Tag CoIP	28514442
种属内	MRPL12	P52815	POLRMT	Homo sapiens	O00411	Anti Tag CoIP	22003127
种属内	MRPL12	P52815	POLRMT	Homo sapiens	O00411	Anti Bait CoIP	22003127
种属内	MRPL12	P52815	POLRMT	Homo sapiens	O00411	Anti Tag CoIP	33961781
种属内	MRPL12	P52815	MORF4L2	Homo sapiens	Q15014	Validated Y2H	32296183
种属内	MRPL12	P52815	SEPTIN1	Homo sapiens	Q8WYJ6	Validated Y2H	32296183
种属内	MRPL12	P52815	PPP1R16A	Homo sapiens	Q96I34	Validated Y2H	32296183
种属内	MRPL12	P52815	MAPRE3	Homo sapiens	Q9UPY8	Validated Y2H	32296183
种属内	MRPL12	P52815	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
种属内	MRPL12	P52815	CBX3	Homo sapiens	Q13185	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Combined Oxidative Phosphorylation Deficiency 45

COXPD45

Neuropathy, Hereditary Motor And Sensory, Type Via, With Optic Atrophy

Peripheral Neuropathy And Optic Atrophy	Cmt6
Charcot-Marie-Tooth Disease Type 6	Hmsn Vi
HMSN6A	Hmsn Via
Hmsn6	Cmt6a
Charcot-Marie-Tooth Disease, Type 6	Hereditary Motor And Sensory Neuropathy Type 6
Hereditary Motor And Sensory Neuropathy Type Vi	Neuropathy, Hereditary Motor And Sensory, Type 6a
Neuropathy, Hereditary Motor And Sensory, Type Vi	Charcot-Marie-Tooth Disease, Type 6a
Hereditary Motor And Sensory Neuropathy Via	Hmsn 6
Neuropathy, Hereditary Motor And Sensory, 6a, With Optic Atrophy	Charcot-Marie-Tooth Disease 6
Charcot-Marie-Tooth Disease 6a	Hereditary Motor And Sensory Neuropathy Type Via
Hereditary Motor And Sensory Neuropathy Vi

Mitochondrial Complex Iv Deficiency, Nuclear Type 1

Cytochrome C Oxidase Deficiency	Mitochondrial Complex Iv Deficiency
Cox Deficiency	Cytochrome-C Oxidase Deficiency Disease
MC1DN4	Cytochrome-C Oxidase Deficiency
MC4DN1	Mitochondrial Complex I Deficiency, Nuclear Type 4
Complex 4 Mitochondrial Respiratory Chain Deficiency	Complex Iv Deficiency
Mitochondrial Complex 1 Deficiency, Nuclear Type 4	Nuclear Type Mitochondrial Complex I Deficiency 4
Deficiency Of Mitochondrial Respiratory Chain Complex4	MT-C4D
Complex Iv Mitochondrial Respiratory Chain Deficiency	Lethal Neonatal Cardiomyopathy Hypertrophic Due To Cytochrome C Oxidase Deficiency
Mitochondrial Complex Iv Deficiency, Nuclear, Type 1

Perrault Syndrome

Gonadal Dysgenesis, Xx Type, With Deafness	Ovarian Dysgenesis With Sensorineural Deafness
Gonadal Dysgenesis, Xx Type	Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance
Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance	Xx Gonodal Dysgenesis-Deafness Syndrome
Xx Gonodal Dysgenesis-Hearing Loss Syndrome	Gonadal Dysgenesis Xx Type Deafness

Leigh Syndrome

Leigh Disease	Infantile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency	LS
Sne	Leigh'S Disease
Leigh Syndrome Due To Mitochondrial Complex I Deficiency	Necrotizing Encephalopathy, Infantile Subacute, Of Leigh
Subacute Necrotizing Encephalomyelopathy	Necrotizing Encephalopathy Infantile Subacute Of Leigh
Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency	Infantile Necrotizing Encephalomyelopathy
Juvenile Subacute Necrotizing Encephalomyelopathy	Leigh'S Necrotizing Encephalopathy
Subacute Necrotizing Encephalopathy	Juvenile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency	Leigh Syndrome Due To Mitochondrial Complex V Deficiency
Encephalopathy, Subacute Necrotizing, Infantile	Encephalopathy, Subacute Necrotizing, Juvenile
Maternally Inherited Leigh Syndrome	Subacute Necrotising Encephalomyelopathy
Subacute Necrotising Encephalopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08663	MRPL12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	MRPL12	RGD	RGD:1588559
Mus musculus	MRPL12	MGD	MGI:1926273
Bos taurus	MRPL12	VGNC	VGNC:106827

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MRPL12 - mitochondrial ribosomal protein L12 Gene

关于 MRPL12

功能概要

MRPL12 基因产物(1)

MRPL12 蛋白结构

MRPL12 蛋白互作信息

关联疾病

直系同源

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MRPL12 - mitochondrial ribosomal protein L12 Gene

关于 MRPL12

功能概要

MRPL12 基因产物(1)

MRPL12 蛋白结构

MRPL12 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z