SEPTIN1 - septin 1 Gene

中文名称：脓毒症 1

种属: Homo sapiens

同用名: LARP; SEP1; DIFF6; SEPT1; PNUTL3

基因 ID: 1731 | 基因类型: protein coding

关于 SEPTIN1

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,378,135-30,382,815 (from NCBI)

This gene has 11 transcripts (splice variants), 104 orthologues and 12 paralogues. Biased expression in lymph node (RPKM 27.2), spleen (RPKM 18.3) and 9 other tissues.

功能概要

该基因是 GTP 酶的败血症家族的成员。该家族的成员是胞质分裂和维持细胞形态所必需的。该基因编码的蛋白质可以形成同源和异源寡聚丝，并可能有助于阿尔茨海默病中神经原纤维缠结的形成。已发现可变剪接的转录本变体，但尚未确定这些变体的全长性质。[RefSeq 提供，2012 年 12 月]

This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012]

SEPTIN1 基因产物(2)

mRNA	Protein	Name
NM_001365977.2	NP_001352906.1	septin-1
NM_052838.6	NP_443070.6	septin-1

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16179162	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in midbody	IDA IDA: 通过直接分析推断	19799413	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SEPTIN1 蛋白结构

Septin

0
100
200
300
414 a.a.

蛋白主名

其他名称

septin-1

differentiation 6 (deoxyguanosine triphosphate triphosphohydrolase)

SEPTIN1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SEPTIN1	Q8WYJ6	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
种属内	SEPTIN1	Q8WYJ6	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	32296183
种属内	SEPTIN1	Q8WYJ6	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	32296183
种属内	SEPTIN1	Q8WYJ6	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
种属内	SEPTIN1	Q8WYJ6	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
种属内	SEPTIN1	Q8WYJ6	GPSM1	Homo sapiens	Q86YR5-3	Y2H Array	32296183
种属内	SEPTIN1	Q8WYJ6	GPSM1	Homo sapiens	Q86YR5-3	Y2H Prey Pooling	32296183
种属内	SEPTIN1	Q8WYJ6	DNAJB13	Homo sapiens	P59910	Y2H Prey Pooling	32296183
种属内	SEPTIN1	Q8WYJ6	DNAJB13	Homo sapiens	P59910	Y2H Array	32296183
种属内	SEPTIN1	Q8WYJ6	AMOT	Homo sapiens	A2BDD9	Y2H Prey Pooling	32296183
种属内	SEPTIN1	Q8WYJ6	AMOT	Homo sapiens	A2BDD9	Y2H Array	32296183
种属内	SEPTIN1	Q8WYJ6	SEPTIN12	Homo sapiens	Q8IYM1	Y2H Array	31515488
种属内	SEPTIN1	Q8WYJ6	SEPTIN12	Homo sapiens	Q8IYM1	Y2H Prey Pooling	32296183
种属内	SEPTIN1	Q8WYJ6	SEPTIN12	Homo sapiens	Q8IYM1	Y2H Array	25416956
种属内	SEPTIN1	Q8WYJ6	SEPTIN12	Homo sapiens	Q8IYM1	Y2H Array	32296183
种属内	SEPTIN1	Q8WYJ6	PIH1D1	Homo sapiens	Q9NWS0	Y2H Prey Pooling	32296183
种属内	SEPTIN1	Q8WYJ6	PIH1D1	Homo sapiens	Q9NWS0	Validated Y2H	32296183
种属内	SEPTIN1	Q8WYJ6	PIH1D1	Homo sapiens	Q9NWS0	Y2H Array	32296183
种属内	SEPTIN1	Q8WYJ6	MRPL12	Homo sapiens	P52815	Y2H Array	32296183
种属内	SEPTIN1	Q8WYJ6	MRPL12	Homo sapiens	P52815	Y2H Prey Pooling	32296183
种属内	SEPTIN1	Q8WYJ6	SEPTIN5	Homo sapiens	Q99719	Anti Tag CoIP	33961781
种属内	SEPTIN1	Q8WYJ6	SEPTIN5	Homo sapiens	Q99719	Anti Tag CoIP	28514442
种属内	SEPTIN1	Q8WYJ6	SEPTIN5	Homo sapiens	Q99719	Validated Y2H	32296183
种属内	SEPTIN1	Q8WYJ6	SEPTIN5	Homo sapiens	Q99719	Y2H Prey Pooling	25416956
种属内	SEPTIN1	Q8WYJ6	SEPTIN5	Homo sapiens	Q99719	Y2H Prey Pooling	32296183
种属内	SEPTIN1	Q8WYJ6	SEPTIN5	Homo sapiens	Q99719	Y2H Array	25416956
种属内	SEPTIN1	Q8WYJ6	SEPTIN5	Homo sapiens	Q99719	Y2H Array	32296183
种属内	SEPTIN1	Q8WYJ6	SEPTIN5	Homo sapiens	Q99719	Validated Y2H	25416956
种属内	SEPTIN1	Q8WYJ6	AMOT	Homo sapiens	Q4VCS5-2	Validated Y2H	25416956
种属内	SEPTIN1	Q8WYJ6	AURKB	Homo sapiens	Q96GD4	Y2H	21988832
种属内	SEPTIN1	Q8WYJ6	AURKB	Homo sapiens	Q96GD4	IF	16179162
种属内	SEPTIN1	Q8WYJ6	AURKB	Homo sapiens	Q96GD4	Protein Kinase Assay	16179162
种属内	SEPTIN1	Q8WYJ6	SEPTIN6	Homo sapiens	Q14141	Anti Tag CoIP	33961781
种属内	SEPTIN1	Q8WYJ6	SEPTIN6	Homo sapiens	Q14141	Y2H Prey Pooling	25416956
种属内	SEPTIN1	Q8WYJ6	SEPTIN6	Homo sapiens	Q14141	Y2H Pooling	16189514
种属内	SEPTIN1	Q8WYJ6	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
种属内	SEPTIN1	Q8WYJ6	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
种属内	SEPTIN1	Q8WYJ6	SEPTIN3	Homo sapiens	Q9UH03	Validated Y2H	32296183
种属内	SEPTIN1	Q8WYJ6	SEPTIN3	Homo sapiens	Q9UH03	Y2H Array	32296183
种属内	SEPTIN1	Q8WYJ6	SEPTIN3	Homo sapiens	Q9UH03	Anti Tag CoIP	33961781
种属内	SEPTIN1	Q8WYJ6	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183
种属内	SEPTIN1	Q8WYJ6	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
种属内	SEPTIN1	Q8WYJ6	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183
种属内	SEPTIN1	Q8WYJ6	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	32296183
种属内	SEPTIN1	Q8WYJ6	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
种属内	SEPTIN1	Q8WYJ6	NIF3L1	Homo sapiens	Q9GZT8	Validated Y2H	32296183
种属内	SEPTIN1	Q8WYJ6	NIF3L1	Homo sapiens	Q9GZT8	Y2H Prey Pooling	32296183
种属内	SEPTIN1	Q8WYJ6	NIF3L1	Homo sapiens	Q9GZT8	Y2H Array	32296183
种属内	SEPTIN1	Q8WYJ6	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
种属内	SEPTIN1	Q8WYJ6	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
种属内	SEPTIN1	Q8WYJ6	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
种属内	SEPTIN1	Q8WYJ6	TEX11	Homo sapiens	Q8IYF3	Validated Y2H	25416956
种属内	SEPTIN1	Q8WYJ6	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
种属内	SEPTIN1	Q8WYJ6	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
种属内	SEPTIN1	Q8WYJ6	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
种属内	SEPTIN1	Q8WYJ6	SEPTIN11	Homo sapiens	Q9NVA2	Validated Y2H	32296183
种属内	SEPTIN1	Q8WYJ6	SEPTIN11	Homo sapiens	Q9NVA2	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Amyotrophic Neuralgia

Neuralgic Amyotrophy	Brachial Plexus Neuritis
Neuralgic Shoulder Amyotrophy	Acute Brachial Plexus Neuritis
Immune Brachial Plexus Neuropathy	Mononeuritis Multiplex With Brachial Predilection
Parsonage-Turner Syndrome

Brachial Plexus Neuropathy

Brachial Plexopathy	Brachial Plexus Neuropathies
Brachial Plexus Disorder	Bpn - [Brachial Plexus Neuropathy]
Brachial Plexus Disease	Neuropathic Plexus Brachialis
Brachial Plexus Syndrome	Brachial Plexus Irritation
Brachial Plexus Lesion	Brachial Plexus Pressure
Compression Of Brachial Plexus

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12681	SEPTIN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	SEPTIN1	VGNC	VGNC:34449
Macaca mulatta	SEPTIN1	VGNC	VGNC:77323
Felis catus	SEPTIN1	VGNC	VGNC:65008
Mus musculus	SEPTIN1	MGD	MGI:1858916
Rattus norvegicus	SEPTIN1	RGD	RGD:1307216
Canis familiaris	SEPTIN1	VGNC	VGNC:46010

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4