2. Gene
  3. AURKB - aurora kinase B Gene

AURKB - aurora kinase B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：极光激酶 B

种属: Homo sapiens

同用名: AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; ARK-2; STK-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2

基因 ID: 9212 | 基因类型: protein coding

关于 AURKB

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,204,731-8,210,575 (from NCBI)

This gene has 14 transcripts (splice variants), 216 orthologues and 2 paralogues. Biased expression in lymph node (RPKM 11.6), bone marrow (RPKM 10.7) and 11 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸激酶的极光激酶亚家族成员。编码该亚科另外两个成员的基因位于 19 号和 20 号染色体上。这些激酶通过与微管结合参与有丝分裂和减数分裂过程中染色体排列和分离的调节。该基因的假基因位于 8 号染色体上。已发现该基因的可变剪接转录物变体。[RefSeq 提供，2015 年 9 月]

This gene encodes a member of the Aurora Kinase subfamily of serine/threonine kinases. The genes encoding the Other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]

AURKB 基因产物(15)

mRNA Protein Name
NR_132731.1
NM_001313955.2 NP_001300884.1 aurora kinase B isoform 7
NM_001313950.2 NP_001300879.1 aurora kinase B isoform 1
XM_017025311.2 XP_016880800.1 aurora kinase B isoform X3
XM_047437051.1 XP_047293007.1 aurora kinase B isoform X2
NM_001313954.2 NP_001300883.1 aurora kinase B isoform 6
NM_001313951.1 NP_001300880.1 aurora kinase B isoform 2
NM_001284526.2 NP_001271455.1 aurora kinase B isoform 3
XM_011524072.4 XP_011522374.1 aurora kinase B isoform X1
XM_047437050.1 XP_047293006.1 aurora kinase B isoform X1
NM_001313952.2 NP_001300881.1 aurora kinase B isoform 4
NM_001313953.3 NP_001300882.1 aurora kinase B isoform 5
NR_132730.2
NM_004217.4 NP_004208.2 aurora kinase B isoform 1
NM_001256834.3 NP_001243763.1 aurora kinase B isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables kinase binding IPI
IPI: 通过物理相互作用推断
23036704 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12689593 GOA
enables protein serine/threonine kinase activity EXP
EXP: 通过实验结果推断
21397845 GOA
NOT enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
26829474 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
18455984 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell cycle G2/M phase transition IDA
IDA: 通过直接分析推断
33542149 GOA
involved in cellular response to UV IDA
IDA: 通过直接分析推断
20959462 GOA
involved in cleavage furrow formation IDA
IDA: 通过直接分析推断
16103226 GOA
involved in mitotic sister chromatid biorientation IDA
IDA: 通过直接分析推断
22371557 GOA
involved in mitotic spindle midzone assembly IMP
IMP: 通过突变表型推断
16103226 GOA
involved in negative regulation of B cell apoptotic process IDA
IDA: 通过直接分析推断
20959462 GOA
involved in negative regulation of cGAS/STING signaling pathway IDA
IDA: 通过直接分析推断
33542149 GOA
involved in negative regulation of innate immune response IDA
IDA: 通过直接分析推断
33542149 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
20959462 GOA
involved in positive regulation of cytokinesis IMP
IMP: 通过突变表型推断
16103226 GOA
involved in positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore IDA
IDA: 通过直接分析推断
28751710 GOA
involved in positive regulation of microtubule depolymerization IDA
IDA: 通过直接分析推断
31804178 GOA
involved in positive regulation of mitotic sister chromatid segregation IDA
IDA: 通过直接分析推断
26829474 GOA
acts upstream of or within positive regulation of telomere maintenance IMP
IMP: 通过突变表型推断
21531765 GOA
involved in protein localization to kinetochore IMP
IMP: 通过突变表型推断
19468067 GOA
involved in repair of mitotic kinetochore microtubule attachment defect IDA
IDA: 通过直接分析推断
22371557 GOA
involved in spindle organization IMP
IMP: 通过突变表型推断
21820309 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of chromosome passenger complex IPI
IPI: 通过物理相互作用推断
15260989 GOA
located in condensed chromosome, centromeric region IDA
IDA: 通过直接分析推断
18195732 GOA
is active in kinetochore IDA
IDA: 通过直接分析推断
26829474 GOA
located in kinetochore IDA
IDA: 通过直接分析推断
22024163 GOA
located in microtubule cytoskeleton IDA
IDA: 通过直接分析推断
9859993 GOA
located in midbody IDA
IDA: 通过直接分析推断
17726514 GOA
located in nucleus IDA
IDA: 通过直接分析推断
20959462 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AURKB 蛋白结构

Pkinase

Pkinase: Protein kinase domain (77 - 327)

  • 0
  • 100
  • 200
  • 300
  • 344 a.a.
蛋白主名 其他名称

aurora kinase B

aurora kinase B-Sv1

aurora kinase B-Sv2

aurora- and Ipl1-like midbody-associated protein 1

aurora-1

aurora-B

aurora-related kinase 2

aurora/IPL1-related kinase 2

protein phosphatase 1, regulatory subunit 48

serine/threonine kinase 12

serine/threonine-protein kinase 12

serine/threonine-protein kinase 5

serine/threonine-protein kinase aurora-B

AURKB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra AURKB Q96GD4 HSP90AA5P Homo sapiens Q58FG0
Anti Tag CoIP
33961781
Intra AURKB Q96GD4 HSP90AA5P Homo sapiens Q58FG0
Anti Tag CoIP
28514442
Intra AURKB Q96GD4 VRK1 Homo sapiens Q99986
Protein Kinase Assay
29340707
Intra AURKB Q96GD4 KLHL13 Homo sapiens Q9P2N7
Pull Down
17543862
Intra AURKB Q96GD4 KLHL9 Homo sapiens Q9P2J3
Pull Down
17543862
Intra AURKB Q96GD4 USP29 Homo sapiens Q9HBJ7
Anti Bait CoIP
38233848
Intra AURKB Q96GD4 CDC37 Homo sapiens Q16543
Anti Tag CoIP
35271311
Intra AURKB Q96GD4 CDC37 Homo sapiens Q16543
Lumier
25036637
Intra AURKB Q96GD4 CDC37 Homo sapiens Q16543
Pull Down
32707033
Intra AURKB Q96GD4 CDC37 Homo sapiens Q16543
BioID
29568061
Intra AURKB Q96GD4 CDC37 Homo sapiens Q16543
Pull Down
29568061
Intra AURKB Q96GD4 PPP2R1A Homo sapiens P30153
Anti Tag CoIP
26829474
Intra AURKB Q96GD4 PPP2R1A Homo sapiens P30153
Pull Down
32707033
Intra AURKB Q96GD4 INCENP Homo sapiens Q9NQS7
Anti Tag CoIP
19357306
Intra AURKB Q96GD4 INCENP Homo sapiens Q9NQS7
Anti Tag CoIP
27332895
Intra AURKB Q96GD4 INCENP Homo sapiens Q9NQS7
Anti Bait CoIP
27332895
Intra AURKB Q96GD4 INCENP Homo sapiens Q9NQS7
Anti Tag CoIP
17956729
Intra AURKB Q96GD4 INCENP Homo sapiens Q9NQS7
Pull Down
29568061
Intra AURKB Q96GD4 INCENP Homo sapiens Q9NQS7
Pull Down
32707033
Intra AURKB Q96GD4 INCENP Homo sapiens Q9NQS7
Anti Tag CoIP
35271311
Intra AURKB Q96GD4 INCENP Homo sapiens Q9NQS7
Y2H
20739936
Intra AURKB Q96GD4 INCENP Homo sapiens Q9NQS7
Anti Tag CoIP
33961781
Intra AURKB Q96GD4 INCENP Homo sapiens Q9NQS7
BioID
29568061
Intra AURKB Q96GD4 INCENP Homo sapiens Q9NQS7
PLA
21051298
Intra AURKB Q96GD4 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
Intra AURKB Q96GD4 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
28514442
Intra AURKB Q96GD4 HSP90AB1 Homo sapiens P08238
Pull Down
29568061
Intra AURKB Q96GD4 H3-4 Homo sapiens Q16695
Protein Kinase Assay
29340707
Intra AURKB Q96GD4 KAT5 Homo sapiens Q92993
GMS
26829474
Intra AURKB Q96GD4 BIRC5 Homo sapiens O15392
Pull Down
16291752
Intra AURKB Q96GD4 BIRC5 Homo sapiens O15392
BioID
29568061
Intra AURKB Q96GD4 BIRC5 Homo sapiens O15392
Anti Tag CoIP
27332895
Intra AURKB Q96GD4 BIRC5 Homo sapiens O15392
Pull Down
17099693
Intra AURKB Q96GD4 BIRC5 Homo sapiens O15392
Anti Tag CoIP
19357306
Intra AURKB Q96GD4 BIRC5 Homo sapiens O15392
Anti Bait CoIP
27332895
Intra AURKB Q96GD4 BIRC5 Homo sapiens O15392
PLA
21051298
Intra AURKB Q96GD4 BIRC5 Homo sapiens O15392
Anti Tag CoIP
17099693
Intra AURKB Q96GD4 BIRC5 Homo sapiens O15392
Anti Bait CoIP
17681274
Intra AURKB Q96GD4 BIRC5 Homo sapiens O15392-1
Pull Down
16291752
Intra AURKB Q96GD4 BIRC5 Homo sapiens O15392-1
Anti Tag CoIP
16291752
Intra AURKB Q96GD4 BIRC5 Homo sapiens O15392-2
Pull Down
16291752
Intra AURKB Q96GD4 TACC1 Homo sapiens O75410-6
Anti Tag CoIP
15064709
Intra AURKB Q96GD4 SEPTIN1 Homo sapiens Q8WYJ6
Anti Tag CoIP
16179162
Intra AURKB Q96GD4 SEPTIN1 Homo sapiens Q8WYJ6
Y2H
16179162
Intra AURKB Q96GD4 NPM1 Homo sapiens P06748
Anti Tag CoIP
24857377
Intra AURKB Q96GD4 NPM1 Homo sapiens P06748
Pull Down
24857377
Intra AURKB Q96GD4 CDCA8 Homo sapiens Q53HL2
PLA
21051298
Intra AURKB Q96GD4 CDCA8 Homo sapiens Q53HL2
Anti Bait CoIP
20739936
Intra AURKB Q96GD4 CDCA8 Homo sapiens Q53HL2
BioID
29568061
Intra AURKB Q96GD4 CDCA8 Homo sapiens Q53HL2
Anti Tag CoIP
35271311
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Uterine Corpus Cancer

Corpus Uteri Cancer

Malignant Uterine Corpus Neoplasm
Cornelia De Lange Syndrome

De Lange Syndrome

Brachmann De Lange Syndrome

Brachmann-De Lange Syndrome

Cdls

Bdls

Typus Degenerativus Amstelodamensis
Endometrial Serous Adenocarcinoma

Uterine Corpus Serous Adenocarcinoma

Uterine Papillary Serous Carcinoma

Uterine Serous Carcinoma
Nystagmus 3, Congenital, Autosomal Dominant

NYS3

Congenital Nystagmus 3

Autosomal Dominant Congenital Nystagmus 3
Polyploidy

Polyploid

Polyploidy Syndrome
Nk-Cell Enteropathy
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Desmoplastic/Nodular Medulloblastoma

Medulloblastoma With Extensive Nodularity

Desmoplastic Medulloblastoma

Medulloblastoma, Somatic

Medulloblastoma, Desmoplastic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Mben

Medulloblastoma Desmoplastic

Neuroectodermal Tumors, Primitive

Medulloblastomas

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-157396 JAB-2485 98.11% 否
HY-151971 Aurora Kinases-IN-3 Inhibitor 98.47% 否
HY-157480 EGFR/AURKB-IN-1 Inhibitor 99.43% 否
HY-RS01270 AURKB Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-148065 FMF-06-098-1 / 否
HY-10338A Foretinib phosphate Inhibitor / 否
HY-120279A CFI-400437 Inhibitor / 否
HY-123610 BRD-7880 Inhibitor / 否
HY-168540 PROTAC MPS1 degrader 1 Degrader / 否
HY-168543 PROTAC MPS1 degrader 2 Degrader / 否
HY-RS01271 Aurkb Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01272 Aurkb Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus AURKB VGNC VGNC:26351
Canis familiaris AURKB VGNC VGNC:38312
Macaca mulatta AURKB VGNC VGNC:70050
Mus musculus AURKB MGD MGI:107168
Felis catus AURKB VGNC VGNC:60044
Rattus norvegicus AURKB RGD RGD:621625
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